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Review Article | Open Access

Advances in the understanding and enhancement of the human cognitive functions of learning and memory

Noguchi Memorial Institute for Medical Research, University of Ghana, Accra LG 25, Ghana
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Abstract

Learning and memory are among the key cognitive functions that drive the human experience. As such, any defective condition associated with these cognitive domains could affect our navigation through everyday life. For years, researchers have been working toward having a clear understanding of how learning and memory work, as well as ways to improve them. Many advances have been made, as well as some challenges that have also been faced in the process. That notwithstanding, there are prospects with regards to the frontier of the enhancement of learning and memory in humans. This review article selectively highlights four broad areas of focus in research into the understanding and enhancement of learning and memory. Brain stimulation, effects of sleep, effects of stress and emotion, and synaptic plasticity are the main focal areas of this review, in terms of some pivotal research works, findings and theories.

References

[1]
Zeidman P, Maguire EA. Anterior hippocampus: the anatomy of perception, imagination and episodic memory. Nat Rev Neurosci 2016, 17(3): 173182.
[2]
Azzam MB, Easteal RA. Pedagogical strategies for the enhancement of medical education. Med Sci Educ 2021, 31(6): 20412048.
[3]
Melton AW. Implications of short-term memory for a general theory of memory. J Verbal Learn Verbal Behav 1963, 2(1): 121.
[4]
Izquierdo I, Furini CRG, Myskiw JC. Fear memory. Physiol Rev 2016, 96(2): 695750.
[5]
Cushman J, Fanselow M. Fear Conditioning. In Encyclopedia of Behavioral Neuroscience. Koob GF, Le Moal M, Thompson RF, Eds. Elsevier Science, 2010, pp 524531.
[6]
Parker ES, Cahill L, McGaugh JL. A case of unusual autobiographical remembering. Neurocase 2006, 12(1): 3549.
[7]
Schacter DL. The seven sins of memory: how the mind forgets and remembers. Houghton, Mifflin and Company, 2001.
[8]
Lofus E. Memories of things unseen In Current Directions in Psychological Science. SAGE Publications, 2004, pp 145147.
[9]
Schacter DL, Norman KA, Koutstaal W. The cognitive neuroscience of constructive memory. Annu Rev Psychol 1998, 49: 289318.
[10]
Baddeley A. Working memory: theories, models, and controversies. Annu Rev Psychol 2012, 63: 129.
[11]
Baddeley AD, Hitch G. Working memory. In The Psychology of Learning and Motivation: Advances in Research and Theory. G.H. Bower, Ed. New York, NY: Academic Press, 1974, pp 4789.
[12]
Baddeley A. The episodic buffer: a new component of working memory? Trends Cogn Sci 2000, 4(11): 417423.
[13]
Brem A, Ran K, Pascual-leone A. Learning and memory. Handb Clin Neurol 2013, 116: 693737.
[14]
Aben B, Stapert S, Blokland A. About the distinction between working memory and short-term memory. Front Psychol 2012, 3: 301.
[15]
Johnston RS. The role of memory in learning to read, write and spell: A review of recent research. Adv Psychol 1993, 100: 5977.
[16]
Jung MW, Baeg EH, Kim MJ, et al. Plasticity and memory in the prefrontal cortex. Rev Neurosci 2008, 19(1): 2946.
[17]
Nelson A, Perry J, Vann S. The Papez Circuit and Recognition Memory. In Handbook of Object Novelty Recognition. Ennaceur A, Silva MA de S, Eds. Elsevier Science, 2018, pp 217226.
[18]
Kersten M, Swets JA, Cox CR, et al. Attenuating pain with the past: nostalgia reduces physical pain. Front Psychol 2020, 11: 572881.
[19]
Oba K, Noriuchi M, Atomi T, et al. Memory and reward systems coproduce ‘nostalgic’ experiences in the brain. Soc Cogn Affect Neurosci 2016, 11(7): 10691077.
[20]
Hassabis D, Maguire EA. Deconstructing episodic memory with construction. Trends Cogn Sci 2007, 11(7): 299306.
[21]
Scoville WB, Milner B. Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry 1957, 20(1): 1121.
[22]
Maguire EA, Gadian DG, Johnsrude IS, et al. Navigation-related structural change in the hippocampi of taxi drivers. PNAS 2000, 97(8): 43984403.
[23]
Maguire EA, Woollett K, Spiers HJ. London taxi drivers and bus drivers: a structural MRI and neuropsychological analysis. Hippocampus 2006, 16(12): 10911101.
[24]
Schacter DL, Addis DR, Buckner RL. Remembering the past to imagine the future: the prospective brain. Nat Rev Neurosci 2007, 8(9): 657661.
[25]
Hassabis D, Kumaran D, Vann SD, et al. Patients with hippocampal Amnesia cannot imagine new experiences. PNAS 2007, 104(5): 17261731.
[26]
Stern SA, Alberini CM. Mechanisms of memory enhancement. Wiley Interdiscip Rev Syst Biol Med 2013, 5(1): 3753.
[27]
Atri A, Sherman S, Norman KA, et al. Blockade of central cholinergic receptors impairs new learning and increases proactive interference in a word paired-associate memory task. Behav Neurosci 2004, 118(1): 223236.
[28]
Hasselmo ME, McGaughy J. High acetylcholine levels set circuit dynamics for attention and encoding and low acetylcholine levels set dynamics for consolidation. Prog Brain Res 2004, 145: 207231.
[29]
Green A, Ellis KA, Ellis J, et al. Muscarinic and nicotinic receptor modulation of object and spatial n-back working memory in humans. Pharmacol Biochem Behav 2005, 81(3): 575584.
[30]
Inman CS, Manns JR, Bijanki KR, et al. Direct electrical stimulation of the amygdala enhances declarative memory in humans. PNAS 2018, 115(1): 98103.
[31]
Suthana N, Fried I. Deep brain stimulation for enhancement of learning and memory. NeuroImage 2014, 85: 9961002.
[32]
Tyng CM, Amin HU, Saad MNM, et al. The influences of emotion on learning and memory. Front Psychol 2017, 8: 1454.
[33]
Ezzyat Y, Kragel JE, Burke JF, et al. Direct brain stimulation modulates encoding states and memory performance in humans. Curr Biol 2017, 27(9): 12511258.
[34]
Feld GB, Diekelmann S. Sleep smart-optimizing sleep for declarative learning and memory. Front Psychol 2015, 6: 622.
[35]
Marshall L, Helgadóttir H, Mölle M, et al. Boosting slow oscillations during sleep potentiates memory. Nature 2006, 444(7119): 610613.
[36]
Ngo HVV, Martinetz T, Born J, et al. Auditory closed-loop stimulation of the sleep slow oscillation enhances memory. Neuron 2013, 78(3): 545553.
[37]
Mankin EA, Fried I. Modulation of human memory by deep brain stimulation of the entorhinal-hippocampal circuitry. Neuron 2020, 106(2): 218235.
[38]
Suthana N, Haneef Z, Stern J, et al. Memory enhancement and deep-brain stimulation of the entorhinal area. N Engl J Med 2012, 366(6): 502510.
[39]
Maquet P. The role of sleep in learning and memory. Science 2001, 294(5544): 10481052.
[40]
Gais S, Lucas B, Born J. Sleep after learning aids memory recall. Learn Mem 2006, 13(3): 259262.
[41]
Staresina BP, Bergmann TO, Bonnefond M, et al. Hierarchical nesting of slow oscillations, spindles and ripples in the human hippocampus during sleep. Nat Neurosci 2015, 18(11): 16791686.
[42]
Ramadan W, Eschenko O, Sara SJ. Hippocampal sharp wave/ripples during sleep for consolidation of associative memory. PLoS One 2009, 4(8): e6697.
[43]
Buzsáki G. Hippocampal sharp wave-ripple: a cognitive biomarker for episodic memory and planning. Hippocampus 2015, 25(10): 10731188.
[44]
Jiang H, Liu S, Geng X, et al. Pacing hippocampal sharp-wave ripples with weak electric stimulation. Front Neurosci 2018, 12: 164.
[45]
Joo HR, Frank LM. The hippocampal sharp wave–ripple in memory retrieval for immediate use and consolidation. Nat Rev Neurosci 2018, 19(12): 744757.
[46]
Wagner U, Gais S, Born J. Emotional memory formation is enhanced across sleep intervals with high amounts of rapid eye movement sleep. Learn Mem 2001, 8(2): 112119.
[47]
Tononi G, Cirelli C. Sleep and synaptic homeostasis: a hypothesis. Brain Res Bull 2003, 62(2): 143150.
[48]
Tononi G, Cirelli C. Sleep function and synaptic homeostasis. Sleep Med Rev 2006, 10(1): 4962.
[49]
Tononi G, Cirelli C. Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration. Neuron 2014, 81(1): 1234.
[50]
Cirelli C, Tononi G. Is sleep essential? PLoS Biol 2008, 6(8): e216.
[51]
McDermott CM, LaHoste GJ, Chen C, et al. Sleep deprivation causes behavioral, synaptic, and membrane excitability alterations in hippocampal neurons. J Neurosci 2003, 23(29): 96879695.
[52]
Vyazovskiy VV, Cirelli C, Pfister-Genskow M, et al. Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep. Nat Neurosci 2008, 11(2): 200208.
[53]
Maret S, Faraguna U, Nelson AB, et al. Sleep and waking modulate spine turnover in the adolescent mouse cortex. Nat Neurosci 2011, 14(11): 14181420.
[54]
Maquet P, Laureys S, Peigneux P, et al. Experience-dependent changes in cerebral activation during human REM sleep. Nat Neurosci 2000, 3(8): 831836.
[55]
Peigneux P, Laureys S, Fuchs S, et al. Are spatial memories strengthened in the human hippocampus during slow wave sleep? Neuron 2004, 44(3): 535545.
[56]
Ribeiro S, Gervasoni D, Soares ES, et al. Long-lasting novelty-induced neuronal reverberation during slow-wave sleep in multiple forebrain areas. PLoS Biol 2004, 2(1): E24.
[57]
Lansink CS, Goltstein PM, Lankelma JV, et al. Preferential reactivation of motivationally relevant information in the ventral striatum. J Neurosci 2008, 28(25): 63726382.
[58]
Lansink CS, Goltstein PM, Lankelma JV, et al. Hippocampus leads ventral striatum in replay of place-reward information. PLoS Biol 2009, 7(8): e1000173.
[59]
Gulati T, Ramanathan DS, Wong CC, et al. Reactivation of emergent task-related ensembles during slow-wave sleep after neuroprosthetic learning. Nat Neurosci 2014, 17(8): 11071113.
[60]
Harris KD. Sleep replay meets brain–machine interface. Nat Neurosci 2014, 17(8): 10191021.
[61]
Payne JD, Schacter DL, Propper RE, et al. The role of sleep in false memory formation. Neurobiol Learn Mem 2009, 92(3): 327334.
[62]
Diekelmann S, Born J, Wagner U. Sleep enhances false memories depending on general memory performance. Behav Brain Res 2010, 208(2): 425429.
[63]
Wagner U, Gais S, Haider H, et al. Sleep inspires insight. Nature 2004, 427(6972): 352355.
[64]
Diekelmann S, Biggel S, Rasch B, et al. Offline consolidation of memory varies with time in slow wave sleep and can be accelerated by cuing memory reactivations. Neurobiol Learn Mem 2012, 98(2): 103111.
[65]
Lahl O, Wispel C, Willigens B, et al. An ultra short episode of sleep is sufficient to promote declarative memory performance. J Sleep Res 2008, 17(1): 310.
[66]
Scullin MK, McDaniel MA. Remembering to execute a goal: sleep on it!. Psychol Sci 2010, 21(7): 10281035.
[67]
Diekelmann S, Wilhelm I, Wagner U, et al. Sleep improves prospective remembering by facilitating spontaneous-associative retrieval processes. PLoS One 2013, 8(10): e77621.
[68]
Diekelmann S, Wilhelm I, Wagner U, et al. Sleep to implement an intention. Sleep 2013, 36(1): 149153.
[69]
Fischer S, Born J. Anticipated reward enhances offline learning during sleep. J Exp Psychol Learn Mem Cogn 2009, 35(6): 15861593.
[70]
Sterpenich V, Albouy G, Boly M, et al. Sleep-related hippocampo-cortical interplay during emotional memory recollection. PLoS Biol 2007, 5(11): e282.
[71]
Sterpenich V, Albouy G, Darsaud A, et al. Sleep promotes the neural reorganization of remote emotional memory. J Neurosci 2009, 29(16): 51435152.
[72]
Payne JD, Stickgold R, Swanberg K, et al. Sleep preferentially enhances memory for emotional components of scenes. Psychol Sci 2008, 19(8): 781788.
[73]
Payne JD, Chambers AM, Kensinger EA. Sleep promotes lasting changes in selective memory for emotional scenes. Front Integr Neurosci 2012, 6: 108.
[74]
Groch S, Wilhelm I, Diekelmann S, et al. The role of REM sleep in the processing of emotional memories: evidence from behavior and event-related potentials. Neurobiol Learn Mem 2013, 99: 19.
[75]
Groch S, Zinke K, Wilhelm I, et al. Dissociating the contributions of slow-wave sleep and rapid eye movement sleep to emotional item and source memory. Neurobiol Learn Mem 2015, 122: 122130.
[76]
Pace-Schott EF, Milad MR, Orr SP, et al. Sleep promotes generalization of extinction of conditioned fear. Sleep 2009, 32(1): 1926.
[77]
Pace-Schott EF, Verga PW, Bennett TS, et al. Sleep promotes consolidation and generalization of extinction learning in simulated exposure therapy for spider fear. J Psychiatr Res 2012, 46(8): 10361044.
[78]
Colvonen PJ, Straus LD, Acheson D, et al. A review of the relationship between emotional learning and memory, sleep, and PTSD. Curr Psychiatry Rep 2019, 21(1): 2.
[79]
Ohayon MM, Shapiro CM. Sleep disturbances and psychiatric disorders associated with posttraumatic stress disorder in the general population. Compr Psychiatry 2000, 41(6): 469478.
[80]
Plumb TR, Peachey JT, Zelman DC. Sleep disturbance is common among servicemembers and veterans of Operations Enduring Freedom and Iraqi Freedom. Psychol Serv 2014, 11(2): 209219.
[81]
Jenkins MM, Colvonen PJ, Norman SB, et al. Prevalence and mental health correlates of insomnia in first-encounter veterans with and without military sexual trauma. Sleep 2015, 38(10): 15471554.
[82]
Vogel S, Schwabe L. Learning and memory under stress: implications for the classroom. Npj Sci Learn 2016, 1: 16011.
[83]
Smeets T, Giesbrecht T, Jelicic M, et al. Context-dependent enhancement of declarative memory performance following acute psychosocial stress. Biol Psychol 2007, 76(1/2): 116123.
[84]
Schwabe L, Wolf OT. Learning under stress impairs memory formation. Neurobiol Learn Mem 2010, 93(2): 183188.
[85]
Joëls M, Pu Z, Wiegert O, et al. Learning under stress: how does it work? Trends Cogn Sci 2006, 10(4): 152158.
[86]
Roozendaal B. Stress and memory: opposing effects of glucocorticoids on memory consolidation and memory retrieval. Neurobiol Learn Mem 2002, 78(3): 578595.
[87]
Delgado-Moreno R, Robles-Pérez JJ, Clemente-Suárez VJ. Combat stress decreases memory of warfighters in action. J Med Syst 2017, 41(8): 124.
[88]
Smeets T. Acute stress impairs memory retrieval independent of time of day. Psychoneuroendocrinology 2011, 36(4): 495501.
[89]
Kuhlmann S, Piel M, Wolf OT. Impaired memory retrieval after psychosocial stress in healthy young men. J Neurosci 2005, 25(11): 29772982.
[90]
Goldfarb EV. Enhancing memory with stress: Progress, challenges, and opportunities. Brain Cogn 2019, 133: 94105.
[91]
Domes G, Heinrichs M, Rimmele U, et al. Acute stress impairs recognition for positive words—association with stress-induced cortisol secretion. Stress 2004, 7(3): 173181.
[92]
Wirkner J, Weymar M, Löw A, et al. Effects of pre-encoding stress on brain correlates associated with the long-term memory for emotional scenes. PLoS One 2013, 8(9): e68212.
[93]
Joëls M, Karst H, Alfarez D, et al. Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamus. Stress 2004, 7(4): 221231.
[94]
Abercrombie HC, Kalin NH, Thurow ME, et al. Cortisol variation in humans affects memory for emotionally laden and neutral information. Behav Neurosci 2003, 117(3): 505516.
[95]
Buchanan TW, Lovallo WR. Enhanced memory for emotional material following stress-level cortisol treatment in humans. Psychoneuroendocrinology 2001, 26(3): 307317.
[96]
Kuhlmann S, Wolf OT. Arousal and cortisol interact in modulating memory consolidation in healthy young men. Behav Neurosci 2006, 120(1): 217223.
[97]
Sara SJ. The locus coeruleus and noradrenergic modulation of cognition. Nat Rev Neurosci 2009, 10(3): 211223.
[98]
Gibbs ME, Hutchinson DS, Summers RJ. Noradrenaline release in the locus coeruleus modulates memory formation and consolidation; roles for α- and β-adrenergic receptors. Neuroscience 2010, 170(4): 12091222.
[99]
Tully K, Bolshakov VY. Emotional enhancement of memory: how norepinephrine enables synaptic plasticity. Mol Brain 2010, 3: 15.
[100]
Bacon TJ, Pickering AE, Mellor JR. Noradrenaline release from locus coeruleus terminals in the hippocampus enhances excitation-spike coupling in CA1 pyramidal neurons via β-adrenoceptors. Cereb Cortex 2020, 30(12): 61356151.
[101]
Cahill L, Prins B, Weber M, et al. Β-Adrenergic activation and memory for emotional events. Nature 1994, 371(6499): 702704.
[102]
McGaugh JL, Cahill L, Roozendaal B. Involvement of the amygdala in memory storage: interaction with other brain systems. PNAS 1996, 93(24): 1350813514.
[103]
Richter-Levin G, Akirav I. Amygdala-hippocampus dynamic interaction in relation to memory. Mol Neurobiol 2000, 22(1/2/3): 1120.
[104]
Richardson MP, Strange BA, Dolan RJ. Encoding of emotional memories depends on amygdala and hippocampus and their interactions. Nat Neurosci 2004, 7(3): 278285.
[105]
Cahill L, McGaugh JL. Mechanisms of emotional arousal and lasting declarative memory. Trends Neurosci 1998, 21(7): 294299.
[106]
Sharot T, Phelps EA. How arousal modulates memory: disentangling the effects of attention and retention. Cogn Affect Behav Neurosci 2004, 4(3): 294306.
[107]
McGaugh JL. Make mild moments memorable: add a little arousal. Trends Cogn Sci 2006, 10(8): 345347.
[108]
Vuilleumier P. How brains beware: neural mechanisms of emotional attention. Trends Cogn Sci 2005, 9(12): 585594.
[109]
McGaugh JL, Roozendaal B. Role of adrenal stress hormones in forming lasting memories in the brain. Curr Opin Neurobiol 2002, 12(2): 205210.
[110]
Um ER, Plass JL, Hayward EO, et al. Emotional design in multimedia learning. J Edu Psychol 2012, 104(2): 485498.
[111]
Oudeyer PY, Gottlieb J, Lopes M. Intrinsic motivation, curiosity, and learning: theory and applications in educational technologies. Prog Brain Res 2016, 229: 257284.
[112]
Yiend J. The effects of emotion on attention: a review of attentional processing of emotional information. Cogn Emot 2010, 24(1): 347.
[113]
D’Mello S, Lehman B, Pekrun R, et al. Confusion can be beneficial for learning. Learn Instr 2014, 29: 153170.
[114]
Atwood HL, Karunanithi S. Diversification of synaptic strength: presynaptic elements. Nat Rev Neurosci 2002, 3(7): 497516.
[115]
Turrigiano GG. The self-tuning neuron: synaptic scaling of excitatory synapses. Cell 2008, 135(3): 422435.
[116]
Mayford M, Siegelbaum SA, Kandel ER. Synapses and memory storage. Cold Spring Harb Perspect Biol 2012, 4(6): a005751.
[117]
Cajal SR. The Croonian lecture—La fine structure des centres nerveux (in French). Proceed Royal Soc London 1894, 55: 444468.
[118]
Ribeiro S, Shi X, Engelhard M, et al. Novel experience induces persistent sleep-dependent plasticity in the cortex but not in the hippocampus. Front Neurosci 2007, 1(1): 4355.
[119]
Magee JC, Grienberger C. Synaptic plasticity forms and functions. Annu Rev Neurosci 2020, 43: 95117.
[120]
Morris GP, Clark IA, Zinn R, et al. Microglia: a new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research. Neurobiol Learn Mem 2013, 105: 4053.
[121]
Huganir RL, Nicoll RA. AMPARs and synaptic plasticity: the last 25 years. Neuron 2013, 80(3): 704717.
[122]
Diering GH, Huganir RL. The AMPA receptor code of synaptic plasticity. Neuron 2018, 100(2): 314329.
[123]
Tan HL, Chiu SL, Zhu Q, et al. GRIP1 regulates synaptic plasticity and learning and memory. PNAS 2020, 117(40): 2508525091.
[124]
Dharani K. The Biology of Thought: A Neuronal Mechanism in the Generation of Thought-A new Molecular Model. Academic Press, 2014.
[125]
Dityatev A, Rusakov DA. Molecular signals of plasticity at the tetrapartite synapse. Curr Opin Neurobiol 2011, 21(2): 353359.
[126]
Tsien RY. Very long-term memories may be stored in the pattern of holes in the perineuronal net. PNAS 2013, 110(30): 1245612461.
[127]
Sanders J, Cowansage K, Baumgärtel K, et al. Elimination of dendritic spines with long-term memory is specific to active circuits. J Neurosci 2012, 32(36): 1257012578.
[128]
Gogolla N, Caroni P, Lüthi A, et al. Perineuronal nets protect fear memories from erasure. Science 2009, 325(5945): 12581261.
[129]
Xue YX, Xue LF, Liu JF, et al. Depletion of perineuronal nets in the amygdala to enhance the erasure of drug memories. J Neurosci 2014, 34(19): 66476658.
[130]
Senkov O, Andjus P, Radenovic L, et al. Neural ECM molecules in synaptic plasticity, learning, and memory. Prog Brain Res 2014, 214: 5380.
[131]
Happel MF, Niekisch H, Castiblanco Rivera LL, et al. Enhanced cognitive flexibility in reversal learning induced by removal of the extracellular matrix in auditory cortex. PNAS 2014, 111(7): 28002805.
[132]
Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron 2010, 65(2): 165177.
[133]
Sacktor TC. PKMzeta, LTP maintenance, and the dynamic molecular biology of memory storage. Prog Brain Res 2008, 169: 2740.
[134]
Volk LJ, Bachman JL, Johnson R, et al. PKM-ζ is not required for hippocampal synaptic plasticity, learning and memory. Nature 2013, 493(7432): 420423.
[135]
Hyman SE. Addiction: a disease of learning and memory. Am J Psychiatry 2005, 162(8): 14141422.
[136]
Chklovskii DB, Mel BW, Svoboda K. Cortical rewiring and information storage. Nature 2004, 431(7010): 782788.
[137]
Marinelli M, Piazza PV. Interaction between glucocorticoid hormones, stress and psychostimulant drugs. Eur J Neurosci 2002, 16(3): 387394.
[138]
Schultz W, Dayan P, Montague PR. A neural substrate of prediction and reward. Science 1997, 275(5306): 15931599.
[139]
Wikler A, Pescor FT. Classical conditioning of a morphine abstinence phenomenon, reinforcement of opioid-drinking behavior and “relapse” in morphine-addicted rats. Psychopharmacologia 1967, 10(3): 255284.
[140]
Mahncke HW, Connor BB, Appelman J, et al. Memory enhancement in healthy older adults using a brain plasticity-based training program: a randomized, controlled study. PNAS 2006, 103(33): 1252312528.
[141]
Zehnder F, Martin M, Altgassen M, et al. Memory training effects in old age as markers of plasticity: a meta-analysis. Restor Neurol Neurosci 2009, 27(5): 507520.
[142]
Halgren E, Wilson CL. Recall deficits produced by afterdischarges in the human hippocampal formation and amygdala. Electroencephalogr Clin Neurophysiol 1985, 61(5): 375380.
[143]
Halgren E, Wilson CL, Stapleton JM. Human medial temporal-lobe stimulation disrupts both formation and retrieval of recent memories. Brain Cogn 1985, 4(3): 287295.
[144]
Lacruz ME, Valentín A, Seoane JJG, et al. Single pulse electrical stimulation of the hippocampus is sufficient to impair human episodic memory. Neuroscience 2010, 170(2): 623632.
[145]
Nitsche MA, Cohen LG, Wassermann EM, et al. Transcranial direct current stimulation: state of the art 2008. Brain Stimul 2008, 1(3): 206223.
[146]
Jacobs J, Miller J, Lee SA, et al. Direct electrical stimulation of the human entorhinal region and hippocampus impairs memory. Neuron 2016, 92(5): 983990.
[147]
Hamani C, McAndrews MP, Cohn M, et al. Memory enhancement induced by hypothalamic/fornix deep brain stimulation. Ann Neurol 2008, 63(1): 119123.
[148]
Laxton AW, Tang-Wai DF, McAndrews MP, et al. A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease. Ann Neurol 2010, 68(4): 521534.
[149]
Mullinger K, Bowtell R. Combining EEG and fMRI. In Magnetic Resonance Neuroimaging. Methods in Molecular Biology. Modo M, Bulte J, Eds. Humana Press, 2011, pp 303326.
[150]
Bendor D, Wilson MA. Biasing the content of hippocampal replay during sleep. Nat Neurosci 2012, 15(10): 14391444.
[151]
Rasch B, Büchel C, Gais S, et al. Odor cues during slow-wave sleep prompt declarative memory consolidation. Science 2007, 315(5817): 14261429.
[152]
Rudoy JD, Voss JL, Westerberg CE, et al. Strengthening individual memories by reactivating them during sleep. Science 2009, 326(5956): 1079.
[153]
van Dongen EV, Takashima A, Barth M, et al. Memory stabilization with targeted reactivation during human slow-wave sleep. PNAS 2012, 109(26): 1057510580.
[154]
Diekelmann S, Büchel C, Born J, et al. Labile or stable: opposing consequences for memory when reactivated during waking and sleep. Nat Neurosci 2011, 14(3): 381386.
[155]
Diekelmann S. Sleep for cognitive enhancement. Front Syst Neurosci 2014, 8: 46.
[156]
Pitman RK, Rasmusson AM, Koenen KC, et al. Biological studies of post-traumatic stress disorder. Nat Rev Neurosci 2012, 13(11): 769787.
[157]
Kochlamazashvili G, Henneberger C, Bukalo O, et al. The extracellular matrix molecule hyaluronic acid regulates hippocampal synaptic plasticity by modulating postsynaptic L-type Ca2+ channels. Neuron 2010, 67(1): 116128.
[158]
Han XN, Chen M, Wang FS, et al. Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Cell Stem Cell 2013, 12(3): 342353.
[159]
Araque A, Parpura V, Sanzgiri RP, et al. Tripartite synapses: Glia, the unacknowledged partner. Trends Neurosci 1999, 22(5): 208215.
Brain Science Advances
Pages 276-297
Cite this article:
Amoah DK. Advances in the understanding and enhancement of the human cognitive functions of learning and memory. Brain Science Advances, 2022, 8(4): 276-297. https://doi.org/10.26599/BSA.2022.9050023

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Received: 15 August 2022
Revised: 30 September 2022
Accepted: 10 October 2022
Published: 30 November 2022
© The authors 2022.

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