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Review | Open Access | Online First

The application of organoids in toxicity test of environmental pollutants

Yuting Fang1,2, Huraira Akhtar1,2, Ji Wang1,2( )
Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, China
Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China
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Highlights

• Organoids could be excellent alternative models for health risk assessment of environmental pollutants

• The development history of organoid as models for health risk assessment of environmental pollutants were summarized

• The current status of organoids as models for toxicity testing (exposure method, dose, exposure duration, toxic effects, etc.) of environmental pollutants was presented

• The unique advantages and challenges of organoids as toxicity test models were concluded

Graphical Abstract

In this review, we have discussed the reasons why organoids may be excellent alternative models for health risk assessment of environmental pollutants. Specifically, we summarized the development history of organoid as models for health risk assessment of environmental pollutants. Most importantly, we presented the current status of organoids as models for toxicity testing of environmental pollutants, mainly in the areas of neurotoxicity, cardiotoxicity, pulmonary toxicity, hepatotoxicity, nephrotoxicity and enterotoxicity. Finally, we also discussed the unique advantages and challenges of organoids as toxicity test models. It is hoped that this will provide a unique insight into the application of organoids in the field of toxicology.

Abstract

Environmental pollutants are mainly produced by human production and living, and pose a serious threat to human health. Health risk assessments of environmental pollutants are needed in order to contribute to the development of reasonable control measures. In comparison to two-dimensional (2D) cell culture and experimental animals, organoids are excellent alternative models for health risk assessment of environmental pollutants. In this review, we described the development and application of organoids in models for the toxicity testing of environmental pollutants. Finally, there was a discussion of the unique advantages and challenges of organoids as toxicity test models. It is hoped that this will provide a unique insight into the application of organoids in the field of toxicology.

Keywords

organoidsenvironmental pollutantshealth risk assessmentstoxicity test models

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Cell Organoid
DOI: 10.26599/CO.2024.9410002
Cite this article:
Fang Y, Akhtar H, Wang J. The application of organoids in toxicity test of environmental pollutants. Cell Organoid, 2024, https://doi.org/10.26599/CO.2024.9410002

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Received: 30 January 2024
Revised: 09 April 2024
Accepted: 21 April 2024
Published: 26 June 2024
© The Author(s) 2024. Published by Tsinghua University Press

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