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Review Article | Open Access

The chemical composition of the walnut pellicle and its benefits to health

Chen-Rui Zhao1,2Qin Chen1,2Xuan Ma1,2Tian-Yu Yang1,2Wen-Jie Yan1,2Rui-Fen Rong1,2Feng Wang1,2( )
College of Biochemical Engineering, Beijing Union University, Beijing 100023, China
Beijing Key Laboratory of Bioactive Substances and Functional Food, Beijing 100023, China
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Highlights

(1) The main biological activities of the walnut pellicle.

(2) The metabolic way of ellagitannin, the main polyphenolic compound of the walnut pellicle, in vivo was reviewed.

(3) The five main biological activities of the polyphenolic compounds in the walnut pellicle.

(4) The interaction between the polyphenolic compounds in the walnut pellicle and the walnut proteins.

Graphical Abstract

The walnut pellicle is rich in abundant polyphenolic compounds. When they react with salivary proteins, a bitter taste is formed in the oral cavity. As a result, the walnut pellicle is often discarded as waste, causing a waste of resources. This article summarizes the composition of polyphenolic compounds in the walnut pellicle and the related biological activities, providing a theoretical foundation for the development and utilization of the walnut pellicle.

Abstract

Walnut pellicle is a layer of film wrapped around the surface of the walnut kernel. The walnut pellicle is rich in tannin compounds, which can react with salivary proteins to produce a bitter and astringent taste, affecting the taste of walnuts. Consequently, the walnut pellicle is typically discarded as waste during food processing. The paper reviews the composition of polyphenolic compounds in the walnut pellicle, mainly including more than 110 kinds of phenolic compounds such as tannins, flavonoids, and phenolic acids; as well as the progress of research on the functional activities in various fields, including inflammation protection, hypolipidemic, antimicrobial, antitumor, and anti-aging, and other five aspects of bioactivity; and finally, elaborates on the interaction between the polyphenolic compounds of the walnut pellicle and walnut proteins, and the possibility that de-phenolization might reduce the structural properties of walnut proteins during processing.

References

[1]

Fordos, S., Abid, N., Gulzar, M., et al. Recent development in the application of walnut processing by-products (walnut shell and walnut husk). Biomass Conversion and Biorefinery, 2023, 13: 14389–14411. https://doi.org/10.1007/s13399-023-04778-6

[2]

Martínez, M. L., Maestri, D. M. Oil chemical variation in walnut ( Juglans regia L.) genotypes grown in Argentina. European Journal of Lipid Science and Technology, 2008, 110: 1183–1189. https://doi.org/10.1002/ejlt.200800121

[3]

Alasalvar, C., Salvadó, J. S., Ros, E. Bioactives and health benefits of nuts and dried fruits. Food Chemistry, 2020, 314: 126192. https://doi.org/10.1016/j.foodchem.2020.126192

[4]
Song, H., Cong, Z., Wang, C., et al. Research progress on walnut oil: bioactive compounds, health benefits, extraction methods, and medicinal uses. Journal of Food Biochemistry, 2022 , 46: 14504. https://doi.org/10.1111/jfbc.14504
[5]

Zhang, Y. G., Kan, H., Chen, S. X., et al. Comparison of phenolic compounds extracted from Diaphragma juglandis fructus, walnut pellicle, and flowers of Juglans regia using methanol, ultrasonic wave, and enzyme assisted-extraction. Food Chemistry, 2020, 321: 126672. https://doi.org/10.1016/j.foodchem.2020.126672

[6]

Shen, D., Yuan, X., Zhao, Z., et al. Determination of phenolic compounds in walnut kernel and its pellicle by ultra-high-performance liquid chromatography-tandem mass spectrometry. Food Analytical Methods, 2021, 14: 2408–2419. https://doi.org/10.1007/s12161-021-02069-2

[7]

Rong, R. F., Li, Z. X., Liu, X. Z., et al. Primary determination study on contents of nutritional and functional components of walnut kernel pellicle. Food Science, 2008, 29: 541–543.

[8]

Trandafir, I., Cosmulescu, S., Botu, M., et al. Antioxidant activity, and phenolic and mineral contents of the walnut kernel ( Juglans regia L.) as a function of the pellicle color. Fruits, 2016, 71: 177–184. https://doi.org/10.1051/fruits/2016006

[9]

Wu, S. T., Shen, D. Y., Wang, R. H., et al. Phenolic profiles and antioxidant activities of free, esterified and bound phenolic compounds in walnut kernel. Food Chemistry, 2021, 350: 129217. https://doi.org/10.1016/j.foodchem.2021.129217

[10]

Koh, S. J., Choi, Y. I., Kim, Y., et al. Walnut phenolic extract inhibits nuclear factor kappaB signaling in intestinal epithelial cells, and ameliorates experimental colitis and colitis-associated colon cancer in mice. European Journal of Lipid Science and Technology, 2019, 58: 1603–1613. https://doi.org/10.1007/s00394-018-1704-3

[11]

Colaric, M., Veberic, R., Solar, A., et al. Phenolic acids, syringaldehyde, and juglone in fruits of different cultivars of Juglans regia L. Journal of Agricultural and Food Chemistry, 2005, 53: 6390–6396. https://doi.org/10.1021/jf050721n

[12]
Zhao, X. D. Study on extraction, isolation and activity of antioxidant components from walnut kernel pellicle, Xianyang, China: Northwest A&F University, 2022 .
[13]

Sheng, F., Hu, B., Jin, Q., et al. The analysis of phenolic compounds in walnut husk and pellicle by UPLC-Q-Orbitrap HRMS and HPLC. Molecules, 2021, 26: 3013. https://doi.org/10.3390/molecules26103013

[14]

Yan, C., Zhou, Z. Walnut pellicle phenolics greatly influence the extraction and structural properties of walnut protein isolates. Food Research International, 2021, 141: 110163. https://doi.org/10.1016/j.foodres.2021.110163

[15]

Ekambaram, S. P., Perumal, S. S., Balakrishnan, A. Scope of hydrolysable tannins as possible antimicrobial agent: scope of hydrolysable tannins as antimicrobial agents. Phytotherapy Research, 2016, 30: 1035–1045. https://doi.org/10.1002/ptr.5616

[16]

Regueiro, J. Comprehensive identification of walnut polyphenols by liquid chromatography coupled to linear ion trap–orbitrap mass spectrometry. Food Chemistry, 2014, 152: 340–348. https://doi.org/10.1016/j.foodchem.2013.11.158

[17]

Medic, A. Identification and quantification of the major phenolic constituents in Juglans regia L. peeled kernels and pellicles, using HPLC–MS/MS. Food Chemistry, 2021, 352: 129404. https://doi.org/10.1016/j.foodchem.2021.129404

[18]

Chang, Z., Zhang, Q., Liang, W., et al. A comprehensive review of the structure elucidation of tannins from Terminalia Linn. Evidence-Based Complementary and Alternative Medicine, 2019, 2019: 8623909. https://doi.org/10.1155/2019/8623909

[19]

Macierzyński, J., Sójka, M., Kosmala, M., et al. Transformation of oligomeric ellagitannins, typical for Rubus and Fragaria genus, during strong acid hydrolysis. Journal of Agricultural and Food Chemistry, 2020, 68: 8212–8222. https://doi.org/10.1021/acs.jafc.0c02674

[20]

Buenrostro-Figueroa, J., Miereles, M., Ascacio-Valdés, J. A., et al. Enzymatic Biotransformation of pomegranate ellagitannins: initial approach to reaction conditions. Iranian Journal of Biotechnology, 2020, 18: 2305. https://doi.org/10.30498/ijb.2020.137202.2305

[21]
Brück, W. M., Díaz Escobar, V. D., Droz-dit-Busset, L., et al. Fermentative liberation of ellagic acid from walnut press cake ellagitannins. Foods, 2022 , 11: 3102. https://doi.org/10.3390/foods11193102
[22]

Cerdá, B., Espín, J. C., Parra, S., et al. The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6 H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans. European Journal of Nutrition, 2004, 43: 205–220. https://doi.org/10.1007/s00394-004-0461-7

[23]

Cerdá, B., Llorach, R., Cerón, J. J., et al. Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice. European Journal of Nutrition, 2003, 42: 18–28. https://doi.org/10.1007/s00394-003-0396-4

[24]
Cerdá, B., Tomás-Barberán, F. A., Espín, J. C. Metabolism of antioxidant and chemopreventive ellagitannins from strawberries, raspberries, walnuts, and oak-aged wine in humans: identification of biomarkers and individual variability. Journal of Agricultural and Food Chemistry, 2005 , 53: 227–235. https://doi.org/10.1021/jf049144d
[25]
Iglesias-Aguirre, C. E., González-Sarrías, A., Cortés-Martín, A., et al. In vivo administration of gut bacterial consortia replicates urolithin metabotypes A and B in a non-urolithin-producing rat model. Food & Function, 2023 , 14: 2657–2667. https://doi.org/10.1039/D2FO03957E
[26]

Heilman, J., Andreux, P., Tran, N., et al. Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid. Food and Chemical Toxicology, 2017, 108: 289–297. https://doi.org/10.1016/j.fct.2017.07.050

[27]

Garcia-Muñoz, C., Vaillant, F. Metabolic fate of ellagitannins: implications for health, and research perspectives for innovative functional foods. Critical Reviews in Food Science and Nutrition, 2014, 54: 1584–1598. https://doi.org/10.1080/10408398.2011.644643

[28]

Al-Sayed, E., Korinek, M., Esmat, A., et al. Anti-inflammatory, hepatoprotective and antioxidant activity of ellagitannin isolated from Melaleuca styphelioides. Phytochemistry, 2020, 177: 112429. https://doi.org/10.1016/j.phytochem.2020.112429

[29]

Garcia, G., Pais, T. F., Pinto, P., et al. Bioaccessible raspberry extracts enriched in ellagitannins and ellagic acid derivatives have anti-neuroinflammatory properties. Antioxidants, 2020, 9: 970. https://doi.org/10.3390/antiox9100970

[30]

Piazza, S., Martinelli, G., Fumagalli, M., et al. Ellagitannins from Castanea sativa Mill. leaf extracts impair H. pylori viability and infection-induced inflammation in human gastric epithelial cells. Nutrients, 2023, 15: 1504–1506. https://doi.org/10.3390/nu15061504

[31]

Puljula, E., Walton, G., Woodward, M. J., et al. Antimicrobial activities of ellagitannins against Clostridiales perfringens, Escherichia coli, Lactobacillus plantarum and Staphylococcus aureus. Molecules, 2020, 25: 3714. https://doi.org/10.3390/molecules25163714

[32]

Cai, Y., Zhang, J., Chen, N. G., et al. Recent advances in anticancer activities and drug delivery systems of tannins. Medicinal Research Reviews, 2017, 37: 665–701. https://doi.org/10.1002/med.21422

[33]

Senobari, Z., Karimi, G., Jamialahmadi, K. Ellagitannins, promising pharmacological agents for the treatment of cancer stem cells. Phytotherapy Research, 2022, 3: 231–242. https://doi.org/10.1002/ptr.7307

[34]

Wang, S., Liu, S., Liu, C., et al. Affinity screening of potential anti-obesity and anti-diabetic component from pomegranate peel by co-immobilization of lipase and α-amylase using carbon nanotube and hydrogel. Process Biochemistry, 2023, 126: 51–60. https://doi.org/10.1016/j.procbio.2023.01.002

[35]

Li, H. Abnormal expression of bHLH3 disrupts a flavonoid homeostasis network, causing differences in pigment composition among mulberry fruits. Horticulture Research, 2020, 7: 83. https://doi.org/10.1038/s41438-020-0302-8

[36]

Fang, X. S., Wu, T., Liang, L. J. Broadly targeted metabolomics analysis of differential metabolites between light yellow and purple walnut endocarps. Food Science, 2021, 42: 215–221

[37]

Zeng, Y., Liu, H., Chen, S., et al. Transcriptome analysis of walnut quality formation and color change mechanism of pellicle during walnut development. Gene Expression Patterns, 2022, 45: 119260. https://doi.org/10.1016/j.gep.2022.119260

[38]

Wang, R., Tian, X., Li, Q., et al. Walnut pellicle color affects its phenolic composition: free, esterified and bound phenolic compounds in various colored-pellicle walnuts. Journal of Food Composition and Analysis, 2022, 109: 104470. https://doi.org/10.1016/j.jfca.2022.104470

[39]

Persic, M., Mikulic-Petkovsek, M., Halbwirth, H., et al. Red walnut: characterization of the phenolic profiles, activities and gene expression of selected enzymes related to the phenylpropanoid pathway in pellicle during walnut development. Journal of Agricultural and Food Chemistry, 2018, 66: 2742–2748. https://doi.org/10.1021/acs.jafc.7b05603

[40]

Akter, R., Chan Ahn, J., Nahar, J., et al. Pomegranate juice fermented by tannin acyl hydrolase and Lactobacillus vespulae DCY75 enhance estrogen receptor expression and anti-inflammatory effect. Frontiers in Pharmacology, 2022, 13: 1010103. https://doi.org/10.3389/fphar.2022.1010103

[41]

Henning, S. M., Summanen, P. H., Lee, R. P., et al. Pomegranate ellagitannins stimulate the growth of Akkermansia muciniphila in vivo. Anaerobe, 2017, 43: 56–60. https://doi.org/10.1016/j.anaerobe.2016.12.003

[42]

García-Villalba, R., Tomás-Barberán, F. A., Iglesias-Aguirre, C. E., et al. Ellagitannins, urolithins, and neuroprotection: human evidence and the possible link to the gut microbiota. Molecular Aspects of Medicine, 2023, 89: 101109. https://doi.org/10.1016/j.mam.2022.101109

[43]

Selma, M. V., Espín, J. C., Tomás-Barberán, F. A. Interaction between phenolics and gut microbiota: role in human health. Journal of Agricultural and Food Chemistry, 2009, 57: 6485–6501. https://doi.org/10.1021/jf902107d

[44]

Romo-Vaquero, M., García-Villalba, R., González-Sarrías, A., et al. Interindividual variability in the human metabolism of ellagic acid: contribution of gordonibacter to urolithin production. Journal of Functional Foods, 2015, 17: 785–791. https://doi.org/10.1016/j.jff.2015.06.040

[45]

Zhang, M., Cui, S., Mao, B., et al. Ellagic acid and intestinal microflora metabolite urolithin A: a review on its sources, metabolic distribution, health benefits, and biotransformation. Critical Reviews in Food Science and Nutrition, 2023, 63: 6900–6922. https://doi.org/10.1080/10408398.2022.2036693

[46]
Lin, I. C., Wu, J. Y., Fang, C. Y., et al. Absorption and metabolism of urolithin A and ellagic acid in mice and their cytotoxicity in human colorectal cancer cells. Evidence-Based Complementary and Alternative Medicine, 2023 : 1–11. https://doi.org/10.1155/2023/8264716
[47]

Al-Harbi, S. A., Abdulrahman, A. O., Zamzami, M. A., et al. Urolithins: the gut based polyphenol metabolites of ellagitannins in cancer prevention, a review. Frontiers in Nutrition, 2021, 8: 647582. https://doi.org/10.3389/fnut.2021.647582

[48]

Yu, Z., Cao, M., Wang, Y., et al. Urolithin A attenuates helicobacter pylori-induced damage in vivo. Journal of Agricultural and Food Chemistry, 2022, 70: 11981–11993. https://doi.org/10.1021/acs.jafc.2c03711

[49]
Wang, L., Chen, J., Chen, Q., et al. The gut microbiota metabolite urolithin B prevents colorectal carcinogenesis by remodeling microbiota and PD-L1/HLA-B. Oxidative Medicine and Cellular Longevity, 2023 : 1–16. https://doi.org/10.1155/2023/6480848
[50]

Kujawska, M., Jodynis-Liebert, J. Potential of the ellagic acid-derived gut microbiota metabolite–urolithin A in gastrointestinal protection. World Journal of Gastroenterology, 2020, 26: 3170–3181. https://doi.org/10.3748/wjg.v26.i23.3170

[51]

Xian, W., Deng, Y., Yang, Y., et al. Ameliorative effect of ellagic acid on aging in rats with the potential mechanism relying on the gut microbiota and urolithin A-producing ability. Journal of Agricultural and Food Chemistry, 2023, 71: 7396–7407. https://doi.org/10.1021/acs.jafc.3c00960

[52]

Cortés-Martín, A., García-Villalba, R., González-Sarrías, A., et al. The gut microbiota urolithin metabotypes revisited: the human metabolism of ellagic acid is mainly determined by aging. Food & Function, 2018, 9: 4100–4106. https://doi.org/10.1039/C8FO00956B

[53]

Selma, M. V., Romo-Vaquero, M., García-Villalba, R., et al. The human gut microbial ecology associated with overweight and obesity determines ellagic acid metabolism. Food & Function, 2016, 7: 1769–1774. https://doi.org/10.1039/C5FO01100K

[54]

Carregosa, D., Carecho, R., Figueira, I., et al. Low-molecular weight metabolites from polyphenols as effectors for attenuating neuroinflammation. Journal of Agricultural and Food Chemistry, 2020, 68: 1790–1807. https://doi.org/10.1021/acs.jafc.9b02155

[55]

Kim, J. M., Lee, U., Kang, J. Y., et al. Anti-amnesic effect of walnut via the regulation of BBB function and neuro-inflammation in Aβ1-42-induced mice. Antioxidants, 2020, 9: 976. https://doi.org/ 10.3390/antiox9100976

[56]

Abdelazeem, K. N. M., Kalo, M. Z., Beer-Hammer, S., et al. The gut microbiota metabolite urolithin A inhibits NF-κB activation in LPS stimulated BMDMs. Scientific Reports, 2021, 11: 7117. https://doi.org/10.1038/s41598-021-86514-6

[57]

Lee, G., Park, J. S., Lee, E. J., et al. Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia. Phytomedicine, 2019, 55: 50–57. https://doi.org/10.1016/j.phymed.2018.06.032

[58]
Yu, Q. J., He, J. W., Liu, F., et al., Ellagic acid (EA), a tannin was isolated from Eucalyptus citriodora leaves and its anti-inflammatory activity. Medicinal Chemistry Research, 2021 , 30: 2277–2288. https://doi.org/10.1007/s00044-021-02806-6
[59]

Piwowarski, J. P., Granica, S., Zwierzyńska, M., et al. Role of human gut microbiota metabolism in the anti-inflammatory effect of traditionally used ellagitannin-rich plant materials. Journal of Ethnopharmacology, 2014, 155: 801–809. https://doi.org/10.1016/j.jep.2014.06.032

[60]

Giménez-Bastida, J. A., González-Sarrías, A., Espín, J. C., et al. Inhibition of 5-lipoxygenase-derived leukotrienes and hemiketals as a novel anti-inflammatory mechanism of urolithins. Molecular Nutrition & Food Research, 2020, 64: 2000129. https://doi.org/10.1002/mnfr.202000129

[61]

Xu, J., Yuan, C., Wang, G., et al. Urolithins attenuate LPS-induced neuroinflammation in BV2Microglia via MAPK, Akt, and NF-κB signaling pathways. Journal of Agricultural and Food Chemistry, 2018, 66: 571–580. https://doi.org/10.1021/acs.jafc.7b03285

[62]

Zhou, X. H., Qiao, Q., Zethelius, B., et al. Diabetes, prediabetes and cancer mortality. Diabetologia, 2010, 53: 1867–1876. https://doi.org/10.1007/s00125-010-1796-7

[63]

Li, W., Zhang, X., Sang, H., et al. Effects of hyperglycemia on the progression of tumor diseases. Journal of Experimental & Clinical Cancer Research, 2019, 38: 327. https://doi.org/10.1186/s13046-019-1309-6

[64]

Delgadillo-Puga, C., Torre-Villalvazo, I., Noriega, L. G., et al. Pecans and its polyphenols prevent obesity, hepatic steatosis and diabetes by reducing dysbiosis, inflammation, and increasing energy expenditure in mice fed a high-fat diet. Nutrients, 2023, 15: 2591. https://doi.org/10.3390/nu15112591

[65]

Shi, D., Chen, C., Zhao, S., et al. Walnut polyphenols inhibit pancreatic lipase activity in vitro and have hypolipidemic effect on high-fat diet-induced obese mice. Journal of Food and Nutrition Research, 2014, 2: 757–763. https://doi.org/10.12691/jfnr-2-10-16

[66]

Palabıyık, E., Sulumer, A. N., Uguz, H., et al. Assessment of hypolipidemic and anti-inflammatory properties of walnut ( Juglans regia) seed coat extract and modulates some metabolic enzymes activity in triton WR-1339-INDUCED hyperlipidemia in rat kidney, liver, and heart. Journal of Molecular Recognition, 2023, 36: e3004. https://doi.org/10.1002/jmr.3004

[67]

Lü, O., Wang, L., Li, J., et al. Effects of pomegranate peel polyphenols on lipid accumulation and cholesterol metabolic transformation in L-02 human hepatic cells via the PPARγ-ABCA1/CYP7A1 pathway. Food & Function, 2016, 7: 4976–4983. https://doi.org/10.1039/C6FO01261B

[68]

Kang, I., Kim, Y., Tomás-Barberán, F. A., et al. Urolithin A, C, and D, but not iso-urolithin A and urolithin B, attenuate triglyceride accumulation in human cultures of adipocytes and hepatocytes. Molecular Nutrition & Food Research, 2016, 60: 1129–1138. https://doi.org/10.1002/mnfr.201500796

[69]
Heilmann, C., Ziebuhr, W., Becker, K., Are coagulase-negative staphylococci virulent? Clinical Microbiology and Infection, 2019 , 25: 1071–1080. https://doi.org/10.1016/j.cmi.2018.11.012
[70]

Acquaviva, R., D’Angeli, F., Malfa, G. A., et al. Antibacterial and anti-biofilm activities of walnut pellicle extract ( Juglans regia L.) against coagulase-negative staphylococci. Natural Product Research, 2021, 35: 2076–2081. https://doi.org/10.1080/14786419.2019.1650352

[71]

D’Angeli, F., Malfa, G. A., Garozzo, A., et al. Antimicrobial, antioxidant, and cytotoxic activities of Juglans regia L. pellicle extract. Antibiotics, 2021, 10: 159. https://doi.org/10.3390/antibiotics10020159

[72]

Virtanen, V., Räikkönen, S., Puljula, E., et al. Ellagitannin-lipid interaction by HR-MAS NMR spectroscopy. Molecules, 2021, 26: 373. https://doi.org/10.3390/molecules26020373

[73]

Catanzaro, E., Greco, G., Potenza, L., et al. Natural products to fight cancer: a focus on Juglans regia. Toxins, 2018, 10: 469. https://doi.org/10.3390/toxins10110469

[74]

Lee, M., Li, J., Li, J., et al. Tet2 inactivation enhances the antitumor activity of tumor-infiltrating lymphocytes. Cancer Research, 2021, 81: 1965–1976. https://doi.org/10.1158/0008-5472.CAN-20-3213

[75]

Yang, L., Ma, S., Han, Y., et al. Walnut polyphenol extract attenuates immunotoxicity induced by 4-pentylphenol and 3-methyl-4-nitrophenol in murine splenic lymphocyte. Nutrients, 2016, 8: 287. https://doi.org/10.3390/nu8050287

[76]

Ceci, C., Tentori, L., Atzori, M., et al. Ellagic acid inhibits bladder cancer invasiveness and in vivo tumor growth. Nutrients, 2016, 8: 744. https://doi.org/10.3390/nu8110744

[77]

Zhao, M., Tang, S. N., Marsh, J. L., et al. Ellagic acid inhibits human pancreatic cancer growth in BALB/c nude mice. Cancer Letters, 2013, 337: 210–217. https://doi.org/10.1016/j.canlet.2013.05.009

[78]

Mishra, S., Vinayak, M. Ellagic acid checks lymphoma promotion via regulation of PKC signaling pathway. Molecular Biology Reports, 2013, 40: 1417–1428. https://doi.org/10.1007/s11033-012-2185-8

[79]
Mishra, S., Vinayak, M. Role of ellagic acid in regulation of apoptosis by modulating novel and atypical PKC in lymphoma bearing mice. BMC Complementary and Alternative Medicine, 2015 , 15: 281. https://doi.org/10.1186/s12906-015-0810-5
[80]

Vanella, L., Di Giacomo, C., Acquaviva, R., et al. Apoptotic markers in a prostate cancer cell line: effect of ellagic acid. Oncology Reports, 2013, 30: 2804–2810. https://doi.org/10.3892/or.2013.2757

[81]

Eskandari, E., Heidarian, E., Amini, S., et al. Evaluating the effects of ellagic acid on pSTAT3, pAKT, and pERK1/2 signaling pathways in prostate cancer PC3 cells. Journal of Cancer Research and Therapeutics, 2016, 12: 1266. https://doi.org/10.4103/0973-1482.165873

[82]

Wang, D., Chen, Q., Liu, B., et al. Ellagic acid inhibits proliferation and induces apoptosis in human glioblastoma cells. Acta Cirurgica Brasileira, 2016, 31: 143–149. https://doi.org/10.1590/S0102-865020160020000010

[83]

Xu, W., Xu, J., Wang, T., et al. Ellagic acid and sennoside B inhibit osteosarcoma cell migration, invasion and growth by repressing the expression of c-Jun. Oncology letters, 2018, 16: 898–904. https://doi.org/10.3892/ol.2018.8712

[84]

Duan, J., Li, Y., Gao, H., et al. Phenolic compound ellagic acid inhibits mitochondrial respiration and tumor growth in lung cancer. Food & Function, 2020, 11: 6332–6339. https://doi.org/10.1039/D0FO01177K

[85]
Ho, C. C., Huang, A. C., Yu, C. S., et al. Ellagic acid induces apoptosis in tsgh8301 human bladder cancer cells through the endoplasmic reticulum stress- and mitochondria-dependent signaling pathways: ellagic acid induces apoptosis in TSGH8301 cells. Environmental Toxicology, 2013 , 29: 1262−1274. https://doi.org/10.1002/tox.21857
[86]

Edderkaoui, M., Odinokova, I., Ohno, I., et al. Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells. World Journal of Gastroenterology, 2008, 14: 3672. https://doi.org/10.3748/wjg.14.3672

[87]

Naiki-Ito, A., Chewonarin, T., Tang, M., et al. Ellagic acid, a component of pomegranate fruit juice, suppresses androgen-dependent prostate carcinogenesis via induction of apoptosis: PFJ and EA prevent prostate cancer. The Prostate, 2015, 75: 151–160. https://doi.org/10.1002/pros.22900

[88]

Chen, H. S., Bai, M. H., Zhang, T., et al. Ellagic acid induces cell cycle arrest and apoptosis through TGF-β/Smad3 signaling pathway in human breast cancer MCF-7 cells. International Journal of Oncology, 2015, 46: 1730–1738. https://doi.org/10.3892/ ijo.2015.2870

[89]

Zhang, Y., Li, Q., Niu, Y., et al. Research progress on aging mechanism and drugs and the role of stem cells in anti-aging process. Experimental Gerontology, 2023, 179: 112248. https://doi.org/10.1016/j.exger.2023.112248

[90]

de Grey, A. D. N. J. Free radicals in aging: causal complexity and its biomedical implications. Free Radical Research, 2006, 40: 1244–1249. https://doi.org/10.1080/10715760600913176

[91]

Perez-Campo, R., López-Torres, M., Cadenas, S., et al. The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach. Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, 1998, 168: 149–158. https://doi.org/10.1007/s003600050131

[92]

Luo, J., Si, H., Jia, Z., et al. Dietary anti-aging polyphenols and potential mechanisms. Antioxidants, 2021, 10: 283. https://doi.org/10.3390/antiox10020283

[93]

Tian, W., Wu, B., Sun, L., et al. Protective effect against D-gal-induced aging mice and components of polypeptides and polyphenols in defatted walnut kernel during simulated gastrointestinal digestion. Journal of Food Science, 2021, 86: 2736–2752. https://doi.org/10.1111/1750-3841.15744

[94]

Zhang, M., Tang, X., Mao, B., et al. Inhibition of the NF-κB and mTOR targets by urolithin A attenuates D-galactose-induced aging in mice. Food & Function, 2023, 14: 10375–10386. https://doi.org/10.1039/D3FO03847E

[95]

Rahimi, V. B., Askari, V. R., Mousavi, S. H. Ellagic acid reveals promising anti-aging effects against D-galactose-induced aging on human neuroblastoma cell line, SH-SY5Y: a mechanistic study. Biomedicine & Pharmacotherapy, 2018, 108: 1712–1724. https://doi.org/10.1016/j.biopha.2018.10.024

[96]

Ryu, D., Mouchiroud, L., Andreux, P. A., et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature Medicine, 2016, 22: 879–888. https://doi.org/10.1038/nm.4132

[97]
Zhang, M., Cui, S., Mao, B., et al., Urolithin A produced by novel microbial fermentation possesses anti-aging effects by improving mitophagy and reducing reactive oxygen species in Caenorhabditis elegans. Journal of Agricultural and Food Chemistry, 2023 , 71: 6348–6357. https://doi.org/10.1021/acs.jafc.3c01062
[98]

Mao, X., Hua, Y. Composition, structure and functional properties of protein concentrates and isolates produced from walnut ( Juglans regia L.). International Journal of Molecular Sciences, 2012, 13: 1561–1581. https://doi.org/10.3390/ijms13021561

[99]
Gu, M., Chen, H. P., Zhao, M. M., et al. Identification of antioxidant peptides released from defatted walnut (Juglans Sigillata Dode) meal proteins with pancreatin. LWT-Food Science and Technology, 2015 , 60: 213–220. https://doi.org/10.1016/j.lwt.2014.07.052
[100]

Wang, J., Wu, T., Fang, L., et al. Anti-diabetic effect by walnut ( Juglans mandshurica Maxim.)-derived peptide LPLLR through inhibiting α-glucosidase and α-amylase, and alleviating insulin resistance of hepatic HepG2 cells. Journal of Functional Foods, 2020, 69: 103944. https://doi.org/10.1016/j.jff.2020.103944

[101]

Wu, W., Zhao, S., Chen, C., et al. Optimization of production conditions for antioxidant peptides from walnut protein meal using solid-state fermentation. Food Science and Biotechnology, 2014, 23: 1941–1949. https://doi.org/10.1007/s10068-014-0265-3

[102]

Liu, R., Wu, L., Du, Q., et al. Small molecule oligopeptides isolated from walnut ( Juglans regia L.) and their anti-fatigue effects in mice. Molecules, 2018, 24: 45. https://doi.org/10.3390/molecules24010045

[103]

Rohn, S. Possibilities and limitations in the analysis of covalent interactions between phenolic compounds and proteins. Food Research International, 2014, 65: 13–19. https://doi.org/10.1016/j.foodres.2014.05.042

[104]

Shen, P., Gao, Z., Xu, M., et al. The impact of hempseed dehulling on chemical composition, structure properties and aromatic profile of hemp protein isolate. Food Hydrocolloids, 2020, 106: 105889. https://doi.org/10.1016/j.foodhyd.2020.105889

[105]

Labuckas, D. O., Maestri, D. M., Perelló, M., et al. Phenolics from walnut ( Juglans regia L.) kernels: antioxidant activity and interactions with proteins. Food Chemistry, 2008, 107: 607–612. https://doi.org/10.1016/j.foodchem.2007.08.051

[106]

Wu, Q., Lü, D., Mao, X. Polyphenol removal with ultrasound-assisted ethanol extraction from defatted walnut powder: optimization of conditions and effect on functional properties of protein isolates. Journal of Agricultural and Food Chemistry, 2023, 103: 6995–7005. https://doi.org/10.1002/jsfa.12782

[107]

Wang, Y., Tan, B., Chen, C., et al. The phenolic profile of walnut meal protein isolate and interaction of phenolics with walnut protein. Food Research International, 2023, 170: 113042. https://doi.org/10.1016/j.foodres.2023.113042

[108]

Su, G., Chen, J., Huang, L., et al. Effects of walnut seed coat polyphenols on walnut protein hydrolysates: structural alterations, hydrolysis efficiency, and acetylcholinesterase inhibitory capacity. Food Chemistry, 2024, 437: 137905. https://doi.org/10.1016/j.foodchem.2023.137905

[109]

Huang, X., Yan, C., Lin, M., et al. The effects of conjugation of walnut protein isolate with polyphenols on protein solubility, antioxidant activity, and emulsifying properties. Food Research International, 2022, 161: 111910. https://doi.org/10.1016/j.foodres.2022.111910

[110]

Kong, X., Huang, Z., Zhang, C., et al. Phenolic compounds in walnut pellicle improve walnut ( Juglans regia L.) protein solubility under pH-shifting condition. Food Research International, 2023, 163: 112156. https://doi.org/10.1016/j.foodres.2022.112156

Food & Medicine Homology
Article number: 9420007
Cite this article:
Zhao C-R, Chen Q, Ma X, et al. The chemical composition of the walnut pellicle and its benefits to health. Food & Medicine Homology, 2024, 1(1): 9420007. https://doi.org/10.26599/FMH.2024.9420007

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Received: 08 April 2024
Revised: 22 May 2024
Accepted: 23 May 2024
Published: 04 July 2024
© National R & D Center for Edible Fungus Processing Technology 2024. Published by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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