National R & D Center for edible Fungus Processing technology, Henan University, Kaifeng 475004, China
School of Chemical Sciences, the University of Auckland, Auckland 1010, New Zealand
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Highlights
(1) According to traditional medicine-food homology, there is no strict boundary between food and medicine.
(2) Modern food-medicine homology is more diverse, precise and personalized.
(3) A shift in healthcare focus (from reactive care to preventive care and proactive care).
(4) Technological innovations and scientific advances enable large-scale medicine-food homologous resource discovery and efficacy validation, and make the therapeutic process more enjoyable.
(5) Modernization and internationalization of the “medicine-food homology” concept and practice are imperative and feasible.
Graphical Abstract
Four major aspects (concept, lifestyle, food processing, modernization and internationalization) of transformation from traditional medicine-food homology to modern food-medicine homology.
Abstract
The concept and theory of “medicine and food homology” derived from traditional Chinese medicine (TCM) has greatly influenced the Chinese food culture since ancient times, as the concept recognizes the intrinsic link between medicine and food and has laid the foundation for diet therapy and diet-based health maintenance. As the concept continues to evolve and become more popular worldwide, a shift from an unconscious “(food-like) medicine supplement” to a conscious “food therapy” is evident. This shift influences considerably the global health and wellness industry and is assimilated into modern lifestyles. As a result, the traditional medicine-food homology concept has been transformed to modern food-medicine homology practices. The transformation was accelerated during and post the COVID-19 pandemic. This review places a focus on such transformation. The development and evolution of traditional medicine-food homology practices, and the resulting changes in food processing, dietary patterns, food service, consumer perception and human lifestyles, are reviewed. The urgent need for further modernization and internationalization of the food-medicine homology theory and practice is highlighted, while several research and development aspects that should be pursued in the near future are discussed.
Wu, Q. L., Liang, X. C. Food therapy and medical diet therapy of traditional Chinese medicine. Clinical Nutrition Experimental, 2018, 18: 1–5. https://doi.org/10.1016/j.yclnex.2018.01.001
Yang, X. W., Zhang, L. Scientific exploration on decoction of ginseng by water: decoction leading to transformation of chemical structure of ginsenosides. Modern Chinese Medicine, 2019, 21: 1009–1015. https://doi.org/10.13313/j.issn.1673-4890.20181224007
Niu, B. Z., Xiao Z. Q. Huang Di Nei Jing Su Wen Yi Zhu. Traditional Chinese Medicine Classics Publishing House, Beijing, 2003.
[10]
Chai, K. F., Gu. Y. M., Gang Ma. On the development of food-oriented health-preserving from the perspective of TCM feeding performance. Chinese Journal of Traditional Chinese Medicine, 2011, 29: 5–6. https://doi.org/10.13193/j.archtcm.2011.01.7. chaikf.016
Lu, H. Z., Jiang, M., Zhu, H. Y. Overview of several important food herbal literatures. Pharmacology and Clinics of Chinese Materia Medica, 2013, 4: 49–53.
Cheng, X. Y., Zhang, Q. C. Discussion on life look in Yang Shangshan’s grand simplicity of inner canon of Huangdi. Journal of Traditional Chinese Medicine, 2016 : 1258–1260. https://doi.org/10.13288/j.11-2166/r.2018.14.022
[13]
Li, S. Z., Ma, M. Z. "Compendium of Materia Medica" correction. People’s Medical Publishing House, Beijing, 1982.
[14]
Ren, N. N., Chen, T. Arrangement and research on TCM literature in the Republic of China. Chinese Journal of Library and Information Science for Traditional Chinese Medicine, 2017, 41: 33–36. https://doi.org/10.3969/j.issn.2095-5707.2017.04.008
Wang, X. D. The ideological origin,conceptual connotation,and contemporary development of "Medicine and Food homology”. Journal of Nanjing University of Traditional Chinese Medicine, 2023, 39: 809–813. https://doi.org/10.14148/j.issn.1672-0482.2023.0809
Kang, L., Ge, R. H., Zhou, L., et al. Analysis of development problems and comprehensive development suggestions for Chinese medicine and food homologous industry. Chinese Bulletin of Life Sciences, 2024 : 1–20. http://kns.cnki.net/kcms/detail/31.1600.Q.20240712.1813.012
[18]
Hou, Y., Jiang, J. G. Origin and concept of medicine food homology and its application in modern functional foods. Food & Function, 2013 , 4: 1727–1741. https://doi.org/10.1039/C3FO60295H
Wei, M. H., Yang, L. Q., Zhou, Q. L., et al. Construction of optimal allocation system on the edible agricultural products components of the nutrition and health care based on internet of things. Applied Mechanics and Materials, 2013, 347: 3194–3198. https://doi.org/10.4028/www.scientific.net/AMM.347-350.3194
Xiang, H., Sun-Waterhouse, D., Waterhouse, G. I., et al. Fermentation-enabled wellness foods: a fresh perspective. Food Science and Human Wellness, 2019, 8: 203–243. https://doi.org/10.1016/j.fshw.2019.08.003
Sun-Waterhouse, D. The development of fruit-based functional foods targeting the health and wellness market: a review. International Journal of Food Science & Technology, 2011, 46: 899–920. https://doi.org/10.1111/j.1365-2621.2010.02499.x
Sun-Waterhouse, D., Zhao, M., Waterhouse, G. I. Protein modification during ingredient preparation and food processing: approaches to improve food processability and nutrition. Food and Bioprocess Technology, 2014, 7: 1853–1893. https://doi.org/10.1007/s11947-014-1326-6
Chen, Y., You, L., Sun-Waterhouse, D. Effects of processing on the physicochemical characteristics and health benefits of algae products: trade-offs among food carbon footprint, nutrient profiles, health properties, and consumer acceptance. Trends in Food Science & Technology, 2024, 147: 104375. https://doi.org/10.1016/j.jpgs.2024.104375
Wang, Y. Q., Chen, Q., Li L. H., et al. Transforming the fermented fish landscape: microbiota enable novel, safe, flavorful, and healthy products for modern consumers. Comprehensive Reviews in Food Science and Food Safety, 2023, 22: 3560–3601. https://doi.org/10.1111/1541-4337.13208
Yin, Z., Liu, X., Guo, L., et al. The potential of dietary fiber in building immunity against gastrointestinal and respiratory disorders. Critical Reviews in Food Science and Nutrition, 2023 : 1–19. https://doi.org/10.1080/10408398.2023.2266462
Song, D. X., Jiang, J. G. Hypolipidemic components from medicine food homology species used in China: pharmacological and health effects. Archives of Medical Research, 2017, 48: 569–581. https://doi.org/10.1016/j.arcmed.2018.01.004
Tian, M., Xie, D., Hong, Y., et al. Anti-inflammatory effects and related mechanisms in vitro and in vivo of Hedychium coccineum Rhizome essential oil. Journal of Ethnopharmacology, 2024, 328: 118103. https://doi.org/10.1016/j.jep.2024.118103
Huang, Y., Hu, J., Xia, Q., et al. Amelioration of obesity and inflammation by polysaccharide from unripe fruits of raspberry via gut microbiota regulation. International Journal of Biological Macromolecules, 2024, 261: 129825. https://doi.org/10.1016/j.ijbiomac.2024.129825
Xia, X. X., Xiao, J. Natural ingredients from medicine food homology as chemopreventive reagents against type 2 diabetes mellitus by modulating gut microbiota homoeostasis. Molecules, 2021, 26: 6934–6934. https://doi.org/10.3390/MOLECULES26226934
Guo, P., Zhang, B., Zhao, J., et al. Medicine-food herbs against Alzheimer’S disease: a review of their traditional functional features, substance basis, clinical practices and mechanisms of action. Molecules, 2022, 27: 901. https://doi.org/10.3390/molecules27030901
Ziglio, E., Currie, C., Rasmussen, V. B. The WHO cross-national study of health behavior in school aged children from 35 countries: findings from 2001–2002. Journal of School Health, 2004, 74: 204–206. https://doi.org/10.1111/j.1746-1561.2004.tb07933.x
de Roos, B., Brennan, L. Personalised interventions—a precision approach for the next generation of dietary intervention studies. Nutrients, 2017 , 9: 847. https://doi.org/10.3390/nu9080847
Brennan, L., de Roos, B. Nutrigenomics: lessons learned and future perspectives. The American Journal of Clinical Nutrition, 2021, 113: 503–516. https://doi.org/10.1093/ajcn/nqaa366
Xiao, Z. B., Liu, X. L., Cheng, R. Q., et al. Influence of β-sitosterol on gastric mucosal side effect induced by aspirin and its pharmacological functions. Chinese Journal of Experimental Traditional Medical Formulae, 2016, 22: 148–152. https://doi.org/10.13422/j.cnki.syfjx.2016010148
Jiang, F. J., Bai, L., Yu Z. B., et al, Advances in diagnosis and treatment of autoimmune hemolytic anemia. Journal of Clinical Transfusion and Laboratory Medicine, 2023 , 25: 692–698. https://doi.org/10.3969/j.issn.1671-2587.2023.05.020
[40]
Huang, L. Q., He, C. N., Ma, P., et al. Strategic thinking on the development of food-medicine Industry. Strategic Study of CAE, 2022, 24: 81–87. https://doi.org/10.15302/J-SSCAE-2022.06.008
Zhang, J., Yang, G., Wen, Y., et al. Intestinal microbiota are involved in the immunomodulatory activities of longan polysaccharide. Molecular Nutrition & Food Research, 2017 , 61: 1700466. https://doi.org/10.1002/mnfr.201700466
Park, S. J., Park, D. H., Kim, D. H., et al. The memory-enhancing effects of Euphoria longan fruit extract in mice. Journal of Ethnopharmacology, 2010, 128: 160–165. https://doi.org/10.1016/j.jep.2010.01.001
Li, H., Lei, T., Zhang, J., et al. Longan ( Dimocarpus longan Lour.) aril ameliorates cognitive impairment in AD mice induced by combination of D-gal/AlCl3 and an irregular diet via RAS/MEK/ERK signaling pathway. Journal of Ethnopharmacology, 2021, 267: 113612. https://doi.org/10.1016/j.jep.2020.113612
Liu, L., Wang, J., Rosenberg, D., et al. Fermented beverage and food storage in 13,000 y-old stone mortars at Raqefet Cave, Israel: investigating Natufian ritual feasting. Journal of Archaeological Science: Reports, 2018, 21: 783–793. https://doi.org/10.1016/j.jasrep.2018.08.008
Arranz-Otaegui, A., Gonzalez Carretero, L., Ramsey, M. N., et al. Archaeobotanical evidence reveals the origins of bread 14,400 years ago in northeastern Jordan. Proceedings of the National Academy of Sciences, 2018, 115: 7925–7930. https://doi.org/10.1073/pnas.1801071115
Misra, N. N., Koubaa, M., Roohinejad, S., et al. Landmarks in the historical development of twenty first century food processing technologies. Food Research International, 2017, 97: 318–339. https://doi.org/10.1016/j.foodres.2017.05.001
Benchamas, G., Huang, S., Huang, G. The influence of traditional and new processing technologies on the structure and function of food polysaccharide. Food & Function, 2020, 11: 5718–5725. https://doi.org/10.1039/D0FO00854K
Chen, J., Tsim, K. W. A review of edible jujube, the Ziziphus jujuba fruit: a heath food supplement for anemia prevalence. Frontiers in Pharmacology, 2000, 11: 593655. https://doi.org/10.3389/fphar.2020.593655
Liu, M., Wang, J., Wang, L., et al. The historical and current research progress on jujube–a superfruit for the future. Horticulture Research, 2020, 7: 119. https://doi.org/10.1038/s41438-020-00346-5
Zhao, W. L., Xie, W., Du, S. L., et al. Changes in physicochemical properties related to the texture of lotus rhizomes subjected to heat blanching and calcium immersion. Food Chemistry, 2016 : 211409–211414. https://doi.org/10.1016/j.foodchem.2016.05.075
Utama, D. T., Baek, K. H., Jeong, H. S., et al. Effects of cooking method and final core-temperature on cooking loss, lipid oxidation, nucleotide-related compounds and aroma volatiles of Hanwoo brisket. Asian-Australasian Journal of Animal Sciences, 2018, 31: 293–300. https://doi.org/10.5713/ajas.17.0217
Mao, C. Q., Ji, L., Lu, T. L., et al. Research development of harmful substances and its harm of traditional Chinese medicine after sulfur fumigation. China Journal of Chinese Materia Medica, 2014, 39: 2801–2806. https://doi.org/10.4268/cjcmm20141503
Zhang, Q. M., He, Y., Lu, P. W., et al. Comparison of sterilization effects and influence on targeting ingredients by different sterilization methods. Journal of Henan University (Medical Science), 2005, 24: 29–31. https://doi.org/10.15991/j.cnki.41-1361/r.2005.01.009
Ghassemi-Golezani, K., Aliloo, A. A., Valizadeh, M., et al. Effects of hydro and osmo-priming on seed germination and field emergence of lentil ( Lens culinaris Medik.). Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2008, 36: 29–33. https://doi.org/10.15835/nbha36186
Kubota, M., Hagiwara, N., Shirakawa, T. Disinfection of seeds of cucurbit crops infested with Acidovorax citrulli with dry heat treatment. Journal of Phytopathology, 2021, 160: 364–368. https://doi.org/10.1111/j.1439-0434.2012.01913.x
Wang, Q., Wu, X., Yuan, C., et al. Effect of saturated steam heat treatment on physical and chemical properties of bamboo. Molecules, 2020, 25: 1999. https://doi.org/10.3390/molecules25081999
Katina, K., Arendt, E., Liukkonen, K. H., et al. Potential of sourdough for healthier cereal products. Trends in Food Science & Technology, 2005, 16: 104–112. https://doi.org/10.1016/j.jpgs.2004.03.008
Zhao, Y., Zhao, X., Sun-Waterhouse, D., et al. Two-stage selective enzymatic hydrolysis generates protein hydrolysates rich in Asn-Pro and Ala-His for enhancing taste attributes of soy sauce. Food Chemistry, 2021, 345: 128803. https://doi.org/10.1016/j.foodchem.2020.12880
Gao, R., Sun-Waterhouse, D., Xiang, H., et al. The effect of the Corynebacterium glutamicum on the shortening of fermentation time, physicochemical and sensory properties of soy sauce. International Journal of Food Science & Technology, 2022, 57: 4316–4327. https://doi.org/10.1111/ijfs.15758
Granato, D., Barba, F. J., Bursać Kovačević, D., et al. Functional foods: product development, technological trends, efficacy testing, and safety. Annual Review of Food Science and Technology, 2020, 11: 93–118. https://doi.org/10.1146/annurev-food-032519-051708
Du, Y., Zhang, S., Waterhouse, G. I., et al. High-intensity pulsed electric field-assisted acidic extraction of pectin from citrus peel: physicochemical characteristics and emulsifying properties. Food Hydrocolloids, 2024, 146: 109291. https://doi.org/10.1016/j.foodhyd.2023.109291
Silva, E. K., Bargas, M. A., Arruda, H. S., et al. Supercritical CO2 processing of a functional beverage containing apple juice and aqueous extract of Pfaffia glomerata roots: fructooligosaccharides chemical stability after non-thermal and thermal treatments. Molecules, 2020, 25: 3911. https://doi.org/10.3390/molecules2517391
Huang, X., Li, Y., Cui, C., et al. Structural, functional properties, and in vitro digestibility of sunflower protein concentrate as affected by extraction method: Isoelectric precipitation vs ultrafiltration. Food Chemistry, 2024, 439: 138090. https://doi.org/10.1016/j.foodchem.2023.138090
Su, G., Zheng, X., Zou, J., et al. Insight into the advantages of premixing yeast-wheat gluten and combining ultrasound and transglutaminase pretreatments in producing umami enzymatic protein hydrolysates. Food Chemistry, 2021, 342: 128317. https://doi.org/10.1016/j.foodchem.2020.128317
Hu, Y. J., Wang, Y. Q., Wu, Z. F., et al. Preliminary study on suitability of ozone sterilization in traditional Chinese medicine and its preparation. China Journal of Chinese Materia Medica, 2015, 40: 3137–3141.
Wang, Y., Wang, X. L., Xia, B. Research on technique of sterilization to traditional Chinese medicine by electrostatic method. Journal of Electrostatics, 1992, 28: 1–6. https://doi.org/10.1016/0304-3886(92)90024-N
Malik, F., Nadeem, M., Ainee, A., et al. Quality evaluation of lemon cordial stored at different times with microwave heating (Pasteurization). Sustainability, 2022, 14: 1953. https://doi.org/10.3390/su14041953
Ozturk, H. M., Ozturk, H. K. Effect of pressure on the vacuum cooling of iceberg lettuce. International Journal of Refrigeration, 2009, 32: 402–410. https://doi.org/10.1016/j.ijrefrig.2008.09.009
Ahn, H. S., Yu, S. S., Kim, C. Y., et al. Heat penetration and quality attributes of superheated steam sterilization (SHS) home meal replacement (HMR) meat products stew. LWT, 2024, 191: 115621. https://doi.org/10.1016/j.lwt.2023.115621
Sebastião, V. G., Batista, D., Rebellato, A. P., et al. Sustainable production of naturally colored extruded breakfast cereals from blends of broken rice and vegetable flours. Food Research International, 2023, 172: 113078. https://doi.org/10.1016/j.foodres.2023.113078
Herrera-Cazares, L. A., Luzardo-Ocampo, I., Ramírez-Jiménez, A. K., et al. Influence of extrusion process on the release of phenolic compounds from mango ( Mangifera indica L.) bagasse-added confections and evaluation of their bioaccessibility, intestinal permeability, and antioxidant capacity. Food Research International, 2021, 148: 110591. https://doi.org/10.1016/j.foodres.2021.110591
Chakraborty, P., Bhattacharyya, D. K., Ghosh, M. Extrusion treated meal concentrates of Brassica juncea as functionally improved ingredient in protein and fiber rich breadstick preparation. LWT, 2021, 142: 111039. https://doi.org/10.1016/j.lwt.2021.111039
Muñoz-Pabon, K. S., Roa-Acosta, D. F., Hoyos-Concha, J. L., et al. Quinoa snack production at an industrial level: effect of extrusion and baking on digestibility, bioactive, rheological, and physical properties. Foods, 2022, 11: 3383. https://doi.org/10.3390/foods11213383
Sun-Waterhouse, D., Zhou, J., Wadhwa, S. S. Drinking yoghurts with berry polyphenols added before and after fermentation. Food Control, 2013, 32: 450–460. https://doi.org/10.1016/j.foodcont.2013.01.011
Sun-Waterhouse, D., Zhou, J., Wadhwa, S. S. Effects of adding apple polyphenols before and after fermentation on the properties of drinking yoghurt. Food and Bioprocess Technology, 2012, 5: 2674–2686. https://doi.org/10.1007/s11947-011-0563-1
Xu, F., Zhang, S., Waterhouse, G. I., et al. Yeast fermentation of apple and grape pomaces affects subsequent aqueous pectin extraction: composition, structure, functional and antioxidant properties of pectins. Food Hydrocolloids, 2022, 133: 107945. https://doi.org/10.1016/j.foodhyd.2022.107945
Chai, K. F., Ng, K. R., Samarasiri, M., et al. Precision fermentation to advance fungal food fermentations. Current Opinion in Food Science, 2022, 47: 100881. https://doi.org/10.1016/j.cofs.2022.100881
Liu, H. H., Zeng, H. M., Zhang, G. C., et al. Analysis ofthe changes of description of food and drug homologous herbs from the perspective of psychical transmutation. China Journal of Traditional Chinese Medicine and Pharmacy, 2022, 37: 6123–6126.
Xue, H., Wang, W., Bian, J., et al. Recent advances in medicinal and edible homologous polysaccharides: extraction, purification, structure, modification, and biological activities. International Journal of Biological Macromolecules, 2022, 222: 1110–1126. https://doi.org/10.1016/j.ijbiomac.2022.09.227
Lu, Q., Li, R., Yang, Y., et al. Ingredients with anti-inflammatory effect from medicine food homology plants. Food Chemistry, 2022 , 368: 130610. https://doi.org/10.1016/j.foodchem.2021.130610
Batiha, G. E. S., Beshbishy, A. M., El-Mleeh, A., et al. Traditional uses, bioactive chemical constituents, and pharmacological and toxicological activities of Glycyrrhiza glabra L. (Fabaceae). Biomolecules, 2020, 10: 352. https://doi.org/10.3390/biom10030352
Luo, H., Vong, C. T., Chen, H., et al. Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine. Chinese Medicine, 2019, 14: 48. https://doi.org/10.1186/s13020-019-0270-9
Salustiano, E. J., Dumas, M. L., Silva-Santos, G. G., et al. In vitro and in vivo antineoplastic and immunological effects of pterocarpanquinone LQB-118. Investigational New Drugs, 2016 , 34: 541-551. https://doi.org/10.1007/s10637-016-0359-2
Lu, Y., Zhao, R., Wu, Z. H., et al. Anti oxidant capacity and immuno enhancing act ivity of Lycium bar barum protoplasm. Food and Machinery, 2022, 38: 18–21. https://doi.org/10.13652/j.spjx.1003.5788.2022.90163
Xu, M. W., Shi, J. H., Wang, Y. L., et al. Research progress on identification of property and favour of traditional Chinese medicine. Herald of Medicine, 2023, 42: 701–707. https://doi.org/10.3870/j.issn.1004-0781.2023.05.017
Li, M. Z., Li G. F., Huang Y. L., et al. Research progress on physiological function of active components of Astragalus and their application in food. Food and Fermentation Industries, 2024 : 1-11. https://doi.org/10.13995/j.cnki.11-1802/ts.038902
[97]
Li, M., Han, B., Zhao, H., et al. Biological active ingredients of Astragali Radix and its mechanisms in treating cardiovascular and cerebrovascular diseases. Phytomedicine, 2022, 98: 153918. https://doi.org/10.1016/j.phymed.2021.153918
Dai, M. T., Chai, K. F., Li, X. Y. Discussion on the health and culture of Henan characteristic food materials. Henan Traditional Chinese Medicine, 2013, 33: 1244–1245. https://doi.org/10.16367/j.issn.1003-5028.2013.08.023
Zhang. D., Xu, G. H., Xu, B. H., et al. Effects of soup with angelica, astragalus and pig’s trotters on hematopoietic function of my-elosuppressed model rat. Military Nursing, 2012, 29: 13–15.
Liu, Y., Dong, H., Sun-Waterhouse, D., et al. Three anti-inflammatory polysaccharides from Lonicera japonica Thunb.: insights into the structure-function relationships. Food Science and Human Wellness, 2024, 13: 2197–2207. https://doi.org/10.26599/FSHW.2022.9250183
Zhang, Y X. A brief discussion of traditional chinses medicine’s process and the process of preparing Chinese medicine. Journal of Jinggangshan Medical College, 2001, 8: 60.
Mahato, N., Sinha, M., Sharma, K., et al. Modern extraction and purification techniques for obtaining high purity food-grade bioactive compounds and value-added co-products from citrus wastes. Foods, 2019, 8: 523. https://doi.org/10.3390/foods8110523
Nguyen, T. L., Ora, A., Häkkinen, S. T., et al. Innovative extraction technologies of bioactive compounds from plant by-products for textile colorants and antimicrobial agents. Biomass Conversion and Biorefinery, 2023 : 1-30. https://doi.org/10.1007/s13399-023-04726-4
Xie, Y. H., Li, C. Y., Feng, H. M., et al. Progress in microbial fermentation of active ingredients in traditional Chinese medicine. Chinese Traditional Patent Medicine, 2024 : 1–7.
Khouryieh, H. A. Novel and emerging technologies used by the US food processing industry. Innovative Food Science & Emerging Technologies, 2021, 67: 102559. https://doi.org/10.1016/j.ifset.2020.102559
Mehta, B. M., Deeth, H. C. Blocked lysine in dairy products: formation, occurrence, analysis, and nutritional implications. Comprehensive Reviews in Food Science and Food Safety, 2016, 15: 206–218. https://doi.org/10.1111/1541-4337.12178
Jiao, B., Cassano, A., Drioli, E. Recent advances on membrane processes for the concentration of fruit juices: a review. Journal of Food Engineering, 2004, 63: 303–324. https://doi.org/10.1016/j.jfoodeng.2003.08.003
Wolever, T. M., Johnson, J., Jenkins, A. L., et al. Impact of oat processing on glycaemic and insulinaemic responses in healthy humans: a randomised clinical trial. British Journal of Nutrition, 2019, 121: 1264–1270. https://doi.org/10.1017/S0007114519000370
Tang, X. F., Qi, F. Y., Wang, T. J., et al. Patent application of intelligent quality control technology in traditional Chinese medicine production process: a review. China Journal of Chinese Materia Medica, 2023, 48: 3190–3198. https://doi.org/10.19540/j.cnki.cjcmm.20230404.301
Gong, W. Y., Ding, C. C., Yuan, F., et al. Application research of “big data + artificial intelligence” in the field of nutrition and health. Food and Nutrition in China, 2024 : 1–5. https://doi.org/10.19870/j.cnki.11-3716/ts.20240301.001
[113]
Cheng, J. X., Liu, Q., Zhu, R. F., et al. Interpretation of family nurses dietary therapy theory. Chinese Nursing Research, 2024, 38: 2069–2075.
Chan, R. Y., Chien, W. T. Concepts of body constitution, health and sub-health from traditional Chinese medicine perspective. World Journal of Translational Medicine, 2013, 2: 56–66. https://doi.org/10.5528/wjtm.v2.i3.56
Zhang, X. C. Intergrating Chinese and Western Medicine. Henan Science and Technology Press, Zhengzhou, 2017.
[116]
Xue, F. Y., Yang J. H., Zhou R., et al. Food therapy and drug therapy in “Dongpo Yang Sheng Ji”. Chinese Journal of Basic Medicine in Traditional Chinese Medicine, 2014, 20: 154–155. https://doi.org/10.19945/j.cnki.issn.1006-3250.2014.02.006
Fang, J. H., Zhu, W. F., Liu, H. N. Discussing the dietary regimen and disease prevention and its application as an anti-epidemic measure. Chinese Medicine and Culture, 2020, 3: 146–151. https://doi.org/10.4103/CMAC.CMAC_36_20
Ai, T. M. Medicinal Flora of China (Volume 13) Glossary of Chinese Medicinal Plants. Peking University Medical Press, Beijing, 2021.
[121]
Gao, Y., Xu, Q. N., Cai, M. G., et al. Development and utilization of marine-derived medicine and food homologous products. Chinese Traditional and Herbal Drugs, 2021, 52: 5455–5464. https://doi.org/10.7501/j.issn.0253-2670.2021.17.037
Sun-Waterhouse, D., Waterhouse, G. I., You, L., et al. Transforming insect biomass into consumer wellness foods: a review. Food Research International, 2016, 89: 129–151. https://doi.org/10.1016/j.foodres.2016.10.001
Ekor, M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Frontiers in Pharmacology, 2014, 4: 177. https://doi.org/10.3389/fphar.2013.00177
Raynor, D. K., Dickinson, R., Knapp, P., et al. Buyer beware? does the information provided with herbal products available over the counter enable safe use? BMC Medicine, 2011 , 9: 1–9. https://doi.org/10.1186/1741-7015-9-94
Vanhaelen, M., Vanhaelen-Fastre, R., But, P., et al. Identification of aristolochic acid in Chinese herbs. The Lancet, 1994 , 343: 174. https://doi.org/10.1016/S0140-6736(94)90964-4
Zhou, S., Koh, H. L., Gao, Y., et al. Herbal bioactivation: the good, the bad and the ugly. Life Sciences, 2004, 74: 935–968. https://doi.org/10.1016/j.lfs.2003.09.035
Kim, J. W., Jung, S. Y., Kwon, Y. H., et al. Ginsenoside Rg3 attenuates tumor angiogenesis via inhibiting bioactivities of endothelial progenitor cells. Cancer Biology & Therapy, 2021, 13: 504–515. https://doi.org/10.4161/cbt.19599
Boullata, J. I., Nace, A. M. Safety issues with herbal medicine. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2000, 20: 257–269. https://doi.org/10.1592/phco.20.4.257.34886
Dunnick, J. K., Nyska, A. The toxicity and pathology of selected dietary herbal medicines. Toxicologic Pathology, 2013, 41: 374–386. https://doi.org/10.1177/0192623312466451
Sells, D. M., Brix, A. E., Nyska A., et al. Respiratory tract lesions in non-inhalation studies. Toxicologic Pathology, 2007, 35: 170–177. https://doi.org/10.1080/01926230601059969
European Commission. Directive 2001/83/EC of the European Parliament and of the Council of 6 November 2001 on the Community code relating to medicinal products for human use (consolidated version: 16/11/2012, amended by Directive 2002/98/EC, Directive 2003/63/EC, Directive 2004/24/EC, Directive 2004/27/EC, and Directive 2008/29/EC). Brussel: European Union; c1995–2018.
[136]
European Commission. Directive 2004/24/EC of the European Parliament and of the Council of 31 March 2004 amending, as regards traditional herbal medicinal products, Directive 2001/83/EC on the Community code relating to medicinal products for human use. Brussel: European Union; c1995–2018 [cited 2018 Jul 5]. https://ec.europa.eu/health/sites/health/files/files/eudralex/vol-1/dir_2004_24/dir_2004_24_en.pdf
[137]
Ye, L., Fan, S., Zhao, P., et al. Potential herb–drug interactions between anti-COVID-19 drugs and traditional Chinese medicine. Acta Pharmaceutica Sinica B, 2013, 13: 3598–3637. https://doi.org/10.1016/j.apsb.2023.06.001
Heinrich, M., Yao, R., Xiao, P. “Food and medicine continuum”-why we should promote cross-cultural communication between the global East and West. Chinese Herbal Medicines, 2022 , 14: 3. https://doi.org/10.1016/j.chmed.2021.12.002
Li, G., Lin, P., Wang, K., et al. Artificial intelligence-guided discovery of anticancer lead compounds from plants and associated microorganisms. Trends in Cancer, 2022, 8: 65–80. https://doi.org/10.1016/j.trecan.2021.10.002
Xu, X., Chen, Y., Zhang, X., et al. Modular characteristics and the mechanism of Chinese medicine’s treatment of gastric cancer: a data mining and pharmacology-based identification. Annals of Translational Medicine, 2021, 9: 1777. https://doi.org/10.21037/atm-21-6301
Sun-Waterhouse D-X, Chen X-Y, Liu Z-H, et al. Transformation from traditional medicine-food homology to modern food-medicine homology. Food & Medicine Homology, 2024, 1(1): 9420014. https://doi.org/10.26599/FMH.2024.9420014