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Review Article | Open Access

Inflammation and gut microbiota in the alcoholic liver disease

Yan Gao1,2( )
Biomedical Innovation Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Beijing Key Laboratory for Therapeutic Cancer Vaccines, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
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Highlights

(1) Inflammation is essential to pathogenesis of hepatic diseases, especially inflammasome.

(2) We mainly pay close attention to the activation and function of inflammasome in ALD.

(3) After alcohol stimulation, the metabolites of gut microbiota will change, and then create a vicious cycle to liver.

Graphical Abstract

Alcohol consumption promotes the second stroke of liver cells via action of oxidative stress-related lipid peroxidation and inflammatory cytokines, resulting into inflammatory response. Therefore, inflammasomes are multi-protein complexes which realize the risk and gather to regulate caspase-1 activation. The inflammasome activation particularly needs two signals in other to enlarge inflammation. Additionally, gut microbes are involved in the regulation of inflammation by constructing a gut specific immune system rather than reusing the infectious pathogens. After alcohol stimulation, the metabolites of gut microbiota will change, and then create a vicious cycle to liver.

Abstract

Alcoholic liver disease (ALD) covers including but not limited to oxidative stress. Alcohol, as the primary stroke, promote the second stroke of liver cells via action of oxidative stress-related lipid peroxidation and inflammatory cytokines, resulting into inflammatory response. Inflammation is essential to pathogenesis of hepatic diseases. Therefore, inflammasomes are multi-protein complexes which realize the risk and gather to regulate caspase-1 activation, activating cytokines such as interleukin-1β (IL-1β) and interleukin-18 (IL-18). Unlike inflammatory responses, the inflammasome activation particularly needs two signals in other to enlarge inflammation. It has been discovered in several human hepatic diseases and realized to be a major contributor to organic damage. Especially, we mainly pay close attention to the activation and function of inflammasome in ALD. Additionally, gut microbes are involved in the regulation of inflammation by constructing a gut specific immune system rather than reusing the infectious pathogens. Fungal flora has an auxiliary effect on inflammatory response, metabolic disorders, and bacterial microbial regulation and host defense, while alcohol abuse causes an imbalance in the microflora of human gut as the feed-back. After alcohol stimulation, the metabolites of gut microbiota will change, and then create a vicious cycle to liver. In brief, the application and translation of the current review promises new approaches in the treatment of ALD, especially from inflammasomes and gut microbiota.

Keywords

inflammasomegut microbiotaalcoholic liver diseaseshort chain fatty acidNLR family pyrin domain containing 3

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Food & Medicine Homology
Volume 1 Issue 2,
December 2024
Article number: 9420020
DOI: 10.26599/FMH.2024.9420020
Cite this article:
Gao Y. Inflammation and gut microbiota in the alcoholic liver disease. Food & Medicine Homology, 2024, 1(2): 9420020. https://doi.org/10.26599/FMH.2024.9420020

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Received: 08 June 2024
Revised: 07 July 2024
Accepted: 07 July 2024
Published: 15 August 2024
© National R & D Center for Edible Fungus Processing Technology 2024. Published by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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