Department of Nutrition, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
College of Chemistry and Chemical Engineering, Southeast University, Nanjing 210000, China
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Highlights
(1) The arrival of the intelligent era and the iteration of robotics technology have focused medical means from the macro to the micro and nano scale.
(2) Tumor drug therapy mainly relies on micro-nano robots to realize drug load encapsulation and path editing. It creates a new chemotherapy mode of "identification - penetration - reversal - elimination".
(3) The relevant researches are mostly in the mechanism basis and in vitro or animal test stage, there are still challenges in the clinical transformation and practical application of micro-nanorobots.
Graphical Abstract
With its cellular/subcellular size, microrobots expand a new vision for exploring drug delivery. It has unique advantages in achieving targeted delivery and precise recruitment of chemotherapy drugs. This paper reviews the relevant research at home and abroad in recent years. It searches the relevant literature in the past 10 years with the keywords "tumor drugs" and "micro-nano robots". The results obtained were described according to "research progress of tumor therapeutic drugs", "nano drug delivery system" and "microrobots drug delivery". Then focused the main discussion on "microrobots and cancer drug delivery". Through this research, its micro-size and multi-source drive provides microrobots technical basis. As the result, they can achieve in-vivo motion efficiency, targeted path planning, biological barrier penetration and efficient drug delivery. It might be beneficial for microrobots to earn better therapeutic of tumor drugs, while decreasing side-effects to other tissues and organs in the future.
Abstract
With its cellular/subcellular size, microrobots expand a new vision for exploring drug delivery. It has unique advantages in achieving targeted delivery and precise recruitment of chemotherapy drugs. This paper reviews the relevant research at home and abroad in recent years. It searches the relevant literature in the past 10 years with the keywords “tumor drugs” and “micro-nano robots”. The results obtained were described according to “research progress of tumor therapeutic drugs”, “nano drug delivery system” and “microrobots drug delivery”. Then focused the main discussion on “microrobots and cancer drug delivery”. Through this research, its micro-size and multi-source drive provides microrobots technical basis. As the result, they can achieve in-vivo motion efficiency, targeted path planning, biological barrier penetration and efficient drug delivery. It might be beneficial for microrobots to earn better therapeutic of tumor drugs, while decreasing side-effects to other tissues and organs in the future.
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