Affiliated Jiangning Chinese Medicine Hospital, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, China
Nanjing Jiangning District Hospital of Chinese Medicine, Nanjing, 211199, China
Department of Chemistry, Abdul Wali Khan University, Mardan, 23200, Pakistan
School of Chemistry & Pharmaceutical Sciences, State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Normal University, Guilin, 541004, China
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Highlights
(1) Providing an overview of the compositions and related functions of Panax ginseng from the perspective of medicinal food homology.
(2) Focusing on the material basis of pharmacological and nutritional functions.
(3) Highlighting Gintonin, a substance with medicinal and edible properties, which is different from the saponins and polysaccharides that have been mainly focused on in previous studies.
(4) Emphasizing that the above substances originate from production, including processing and biotransformation, as well as their mechanisms.
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Panax ginseng has been used as a superior herb in Traditional Chinese Medicine (TCM) for at least 2,000 years. This review focuses on the functional material basis and products of Panax ginseng as a “dual-use substance for medicine and food”, and the pharmacological effects of its components on cancer, skin wound, thrombosis, inflammation, neurological disorders, etc.
Abstract
Panax ginseng has been used as a superior herb in traditional Chinese medicine (TCM) for at least 2,000 years. With its outstanding effects of nourishing, tranquilizing, and benefiting the mind, it has been traditionally used as an herbal remedy for a variety of ailments, such as physical weakness, thirst, or insomnia with palpitations. At the same time, it has also been used as a tonic ingredient in the daily diet of the Chinese, and various kinds of supplements made from it have been used to prolong longevity. This review focuses on the application history, current research progress (2004−2023), functional material basis and product development of P. ginseng as a “dual-use substance for medicine and food”, and the pharmacological effects of its components on cancer, skin wound, thrombosis, inflammation, neurological disorders, etc. It also emphasizes the impact of processing technology on the nutritional and pharmacological effects of P. ginseng and reports the trends and challenges of its future research and development.
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References
[1]
Yang, W. Z., Zhang, Y. B., Wu, W. Y., et al. Approaches to establish Q-markers for the quality standards of traditional Chinese medicines. Acta Pharmaceutica Sinica B, 2017, 7: 439–446. https://doi.org/10.1016/j.apsb.2017.04.012
Liu, H. B., Wang, Y. F., Huang, J. L., et al. Analysis on patents of health care products with substances of medicine food homology in China. Chinese Herbal Medicines, 2024, 16: 412–421. https://doi.org/10.1016/j.chmed.2024.03.005
Sun, M. H., Zhang, Y. P., Gao, W. Y., et al. Polysaccharides from Porphyra haitanensis: a review of their extraction, modification, structures, and bioactivities. Molecules, 2024, 29: 3105. https://doi.org/10.3390/molecules29133105
Yao, L. H., Xia, Z. S., Tang, P. L., et al. Botany, traditional uses, phytochemistry, pharmacology, edible uses, and quality control of lablab semen album: a systematic review. Journal of Ethnopharmacology, 2024, 334: 118507. https://doi.org/10.1016/j.jep.2024.118507
R. Chen, Shennong Bencao Jing, Traditional Chinese Medicine Press, Beijing, 2014.
[6]
Qi, L. W., Wang, C. Z., Yuan, C. S. Isolation and analysis of ginseng: advances and challenges. Natural Product Report, 2011, 28: 467–495. https://doi.org/10.1039/C0NP00057D
Yang, W. Z., Hu, Y., Wu, W. Y., et al. Saponins in the genus Panax L. (Araliaceae): a systematic review of their chemical diversity. Phytochemistry, 2014, 106: 7–24. https://doi.org/10.1016/j.phytochem.2014.07.012
Leung, K. W., Wong, A. S. T. Pharmacology of ginsenosides: a literature review. Chinese Medicine, 2010, 5: 20–26. https://doi.org/10.1186/1749-8546-5-20
Li, X., Liu, J., Zuo, T. T., et al. Advances and challenges in ginseng research from 2011 to 2020: the phytochemistry, quality control, metabolism, and biosynthesis. Natural Product Report, 2022, 39: 875–909. https://doi.org/10.1039/d1np00071c
Tian, T. T., Ko, C. N., Luo, W. Y., et al. The anti-aging mechanism of ginsenosides with medicine and food homology. Food & Function, 2023, 14: 9123–9136. https://doi.org/10.1039/d3fo02580b
Kim, K. J., Tabassum, N., Uddin, R. M., et al. Ginseng: a miracle sources of herbal and pharmacological uses. Oriental Pharmacy and Experimental Medicine, 2016, 16: 243–250. https://doi.org/10.1007/s13596-016-0246-6
Wang, L. P., Hao, X. G., Li, X. X., et al. Effects of ginsenoside Rh2 on cisplatin-induced nephrotoxicity in renal tubular epithelial cells by inhibiting endoplasmic reticulum stress. Journal of Biochemical and Molecular Toxicology, 2024, 38: e23768. https://doi.org/10.1002/jbt.23768
Liu, S. N., Wang, H. Y., Liu, S. W., et al. Fermented ginsenosides alleviate acute liver injury induced by CClsub4/sub in mice by regulating the AKT/mTOR signaling pathway. Journal of Medicinal Food, 2024, 27: 10. https://doi.org/10.1089/jmf.2023.k.0322
Chen, X. J., Qian, W. Q., Zhang, Y., et al. Ginsenoside CK cooperates with bone mesenchymal stem cells to enhance angiogenesis post-stroke via GLUT1 and HIF-1α/VEGF pathway. Phytotherapy Research, 2024, 38: 4321–4335. https://doi.org/10.1002/ptr.8235
Zhong, K. Q., Huang, Y. G., Chen, R., et al. The protective effect of ginsenoside Rg1 against sepsis-induced lung injury through PI3K-Akt pathway: insights from molecular dynamics simulation and experimental validation. Scientific Reports, 2024, 14: 16071. https://doi.org/10.1038/s41598-024-66908-y
Liu, M., Li, T. S., Wang, H. J., et al. Methotrexate-modified docetaxel liposome targeting with ginsenoside Rh2 as a membrane stabilizer for the treatment of ovarian cancer. Journal of Drug Delivery Science and Technology, 2024, 98: 105917. https://doi.org/10.1016/J.JDDST.2024.105917
Yin, S. Y., Xia, F. Y., Zou, W. J., et al. Ginsenoside Rg1 regulates astrocytes to promote angiogenesis in spinal cord injury via the JAK2/STAT3 signaling pathway. Journal of Ethnopharmacology, 2024, 334: 118531. https://doi.org/10.1016/j.jep.2024.118531
Gao, Y. N., Guo, M. K., Chen, J. Q., et al. A ginseng polysaccharide protects intestinal barrier integrity in high-fat diet-fed obese mice. International Journal of Biological Macromolecules, 2024 : 133976. https://doi.org/10.1016/j.ijbiomac.2024.133976
Jing, B. T., Wei, M. Y., Chen, H. Q., et al. Pharmacodynamic evaluation and mechanism of ginseng polysaccharide against nephrotoxicity induced by hexavalent chromium. Nutrients, 2024, 16: 1416. https://doi.org/10.3390/nu16101416
Liang) Tao, H. J., Shang, Z. J., Shang, Y. S. Variorum of Shennong’s Classic of Materia, People’s Health Publishing House, Beijing, 1994 .
[23]
Liang) Tao, H. J., Shang, Z. J., Shang, Y. S., et al. Catalogue of Famous Doctors, China Traditional Chinese Medicine Press, Beijing, 2013 .
[24]
Tang) Sun, S. M. Prepared Urgent QianjinYaofang (edited photocopy), Volumes 1-14, 15-30. Shanghai: Shanghai Science and Technology Press, 2000 .
[25]
Ming) Li, S. Z. Compendium of Materia Medica. People’s Health Publishing House, Beijing, 1977 .
[26]
Zhong, H., Tang, Z. Q., Li, Y. F., et al. The historical evolution and practical value of the theory of medicinal food homology. Acupuncture and Herbal Medicine, 2024, 4: 19–35.
Lei, X., Shang, Z. J. Leigong Treatise on the Preparation. Anhui Science and Technology Press, Hefei, 1991 .
[31]
Ming) Li, S. Z., Liu, H. R., Liu, S. H. Compendium of Materia Medica (Volume 1). Huaxia Publishing House, Beijing, 1998 .
[32]
Ming) Chen, J. M., Wang, S. M., Chen, X. P., et al. Bencao Mengqi. People’s Health Publishing House, Beijing, 1988 .
[33]
Lu, Y. Z., Cao, H., Bi, X. Y., et al. Exploring the processing standards of red ginseng in the Chinese pharmacopoeia based on the historical evolution of ginseng processing. Chinese Journal of Traditional Chinese Medicine Information, 2020, 27: 27–29.
Zhu, Y. R. Analysis of the processing methods and principles of ginseng in various dynasties. Inner Mongolia Traditional Chinese Medicine, 2017, 36: 87–88
Zhang, M., Qin, K. M., Li, W. D., et al. Study on chemical composition changes and mechanisms during ginseng processing. Chinese Journal of Traditional Chinese Medicine, 2014, 39: 3701–3706.
Liu, M. Analysis of the medicinal properties and efficacy of ginseng. Journal of Shandong University of Traditional Chinese Medicine, 2012, 36: 110–112.
Han) Hua, T., (Qing) Sun, X. Y. Huashi Zhongzang Jing. China Medical Science and Technology Press, Beijing, 2011 .
[38]
Tang) Wang, T. Secret Essentials of Foreign Affairs. People’s Health Publishing House, Beijing, 1955 .
[39]
Song) Chen, S. W. Taiping Huimin and Ciju Fang. People’s Health Publishing House, Beijing, 1959 .
[40]
Qing) Zhang, Z. Y. Guidelines for Processing Practice. Shanxi Science and Technology Press, Taiyuan, 2014 .
[41]
Lee, B. H., Choi, S. H., Kim, H. J., et al. A brief method for preparation of Gintonin-enriched fraction from ginseng. Biological Pharmaceutical Bulletin, 2015, 38: 1631–1637. https://doi.org/10.1248/bpb.b15-00171
Cho, H. J., Choi, S. H., Kim, H. J., et al. Bioactive lipids in Gintonin-enriched fraction from ginseng. Journal of Ginseng Research, 2019, 43: 209–217. https://doi.org/10.1016/j.jgr.2017.11.006
Hwang, S. H., Shin, T. J., Choi, S. H., et al. Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity. Molecules and Cells, 2012, 33: 151–162. https://doi.org/10.1007/s10059-012-2216-z
Choi, S. H., Hong, M. K., Kim, H. J., et al. Structure of ginseng major latex-like protein 151 and its proposed lysophosphatidic acid-binding mechanism. Acta Crystallographica. Section D: Biological Crystallography, 2015, 71: 1039–1050. https://doi.org/10.1107/S139900471500259X
Chen, Y., Zhao, Z., Chen, H., et al. Chemical differentiation and quality evaluation of commercial Asian and American ginsengs based on a UHPLC-QTOF/MS/MS metabolomics approach. Phytochemical Analysis: PCA, 2014, 26: 145–160. https://doi.org/10.1002/pca.2546
Xu, W., Zhang, J. H., Wang, X. W., et al. Two new triterpenoid saponins from ginseng medicinal fungal substance. Journal of Asian Natural Products Research, 2016, 18: 865–870. https://doi.org/10.1080/10286020.2016.1169274
Lee, D. G., Lee, A. Y., Kim, K. T., et al. Novel dammarane-type triterpene saponins from Panax ginseng root. Chemical & Pharmaceutical Bulletin, 2015, 63: 927–934. https://doi.org/10.1248/cpb.c15-00302
Cho, J. G., Lee, D. Y., Shrestha, S. et al. Three new ginsenosides from the heat-processed roots of Panax ginseng. Chemistry of Natural Compound, 2013, 49: 882–887. https://doi.org/10.1007/s10600-013-0769-8
Lee, D. Y., Kim, H. G., Lee, Y. G., et al. Isolation and quantification of ginsenoside Rh23, a new anti-melanogenic compound from the leaves of Panax ginseng. Molecules (Basel, Switzerland), 2018, 23: 267. https://doi.org/10.3390/molecules23020267
Guan, Q. X., Sun, D. Y., Liu, J. H., et al. A new ginsengenin containing an oxacyclopentane-ring isolated from the acid hydrolysate of total ginsenosides. Chinese Chemical Letters, 2013, 24: 524–526. https://doi.org/10.1016/j.cclet.2013.03.044
Qiu, S., Yang, W. Z., Yao, C. L., et al. Malonylginsenosides with potential antidiabetic activities from the flower buds of Panax ginseng. Journal of Natural Products, 2017, 80: 899–908. https://doi.org/10.1021/acs.jnatprod.6b00789
Wang, Y. S., Jin, Y. P., Gao, W., et al. Complete 1H-NMR and 13C-NMR spectral assignment of five malonyl ginsenosides from the fresh flower buds of Panax ginseng. Journal of Ginseng Research, 2015, 40: 245–250. https://doi.org/10.1016/j.jgr.2015.08.003
Kim, J. A., Son, J. H., Yang, S. Y., et al. A new lupane-type triterpene from the seeds of Panax ginseng with its inhibition of NF-κB. Archives of Pharmacal Research, 2012, 35: 647–651. https://doi.org/10.1007/s12272-012-0408-0
Rho, T., Jeong, H. W., Hong, Y. D., et al. Identification of a novel triterpene saponin from Panax ginseng seeds, pseudoginsenoside RT8, and its antiinflammatory activity. Journal of Ginseng Research, 2020, 44: 145–153. https://doi.org/10.1016/j.jgr.2018.11.001
Ma, L. Y., Yang, X. W. Six new dammarane-type triterpenes from acidic hydrolysate of the stems-leaves of Panax ginseng and their inhibitory–activities against three human cancer cell lines. Phytochemistry Letters, 2015, 13: 406–412. https://doi.org/10.1016/j.phytol.2015.08.002
Ma, L. Y., Zhou, Q. L., Yang, X. W. New SIRT1 activator from alkaline hydrolysate of total saponins in the stems-leaves of Panax ginseng. Bioorganic & Medicinal Chemistry Letters, 2015, 25: 5321–5325. https://doi.org/10.1016/j.bmcl.2015.09.039
Li, K. K., Yang, X. B., Yang, X. W., et al. New triterpenoids from the stems and leaves of Panax ginseng. Fitoterapia, 2012, 83: 1030–1035. https://doi.org/10.1016/j.fitote.2012.05.013
Ma, H. Y., Gao, H. Y., Huang, J., et al. Three new triterpenoids from Panax ginseng exhibit cytotoxicity against human A549 and Hep-3B cell lines. Journal of Natural Medicines, 2012, 66: 576–582. https://doi.org/10.1007/s11418-012-0662-y
Tran, T. L., Kim, Y. R., Yang, J. L., et al. Dammarane triterpenes from the leaves of Panax ginseng enhance cellular immunity. Bioorganic & Medicinal Chemistry, 2014, 22: 499–504. https://doi.org/10.1016/j.bmc.2013.11.002
Yang, X. W., Ma, L. Y., Zhou, Q. L., et al. IRT1 activator isolated from artificial gastric juice incubate of total saponins in stems and leaves of Panax ginseng. Bioorganic & Medicinal Chemistry Letters, 2018, 28: 240–243. https://doi.org/10.1016/j.bmcl.2017.12.067
Yang, J. L., Ha, T. K., Dhodary, B., et al. Dammarane triterpenes as potential SIRT1 activators from the leaves of Panax ginseng. Journal of Natural Products, 2014, 77: 1615–1623. https://doi.org/10.1021/np5002303
Zhou, Q. L., Yang, X. W. Four new ginsenosides from red ginseng with inhibitory activity on melanogenesis in melanoma cells. Bioorganic & Medicinal Chemistry Letters, 2015, 25: 3112–3116. https://doi.org/10.1016/j.bmcl.2015.06.017
Yang, C. K., Xiong, J., Shen, Y. Two new dammarane-type triterpenoids from the stems and leaves of Panax notoginseng. Journal of Asian Natural Products Research, 2021, 23: 341–347. https://doi.org/10.1080/10286020.2020.1731801
Shu, G., Jiang, S., Mu, J., et al. Antitumor immunostimulatory activity of polysaccharides from Panax japonicus C. A. Mey: roles of their effects on CD4+ T cells and tumor associated macrophages. International Journal of Biological Macromolecules, 2018, 111: 430–439. https://doi.org/10.1016/j.ijbiomac.2018.01.011
Niu, J., Pi, Z., Yue, H., et al. Effect of ginseng polysaccharide on the urinary excretion of type 2 diabetic rats studied by liquid chromatography-mass spectrometry. Journal of Chromatography B, Analytical Technologies in The Biomedical and Life Sciences, 2012, 907: 7–12. https://doi.org/10.1016/j.jchromb.2012.08.012
Wang, Y., Chen, Y., Xu, H., et al. Analgesic effects of glycoproteins from Panax ginseng root in mice. Journal of Ethnopharmacology, 2013, 148: 946–950. https://doi.org/10.1016/j.jep.2013.05.049
Wang, L., Yu, X., Yang, X., et al. Structural and anti-inflammatory characterization of a novel neutral polysaccharide from North American ginseng ( Panax quinquefolius). International Journal of Biological Macromolecules, 2015, 74: 12–17. https://doi.org/10.1016/j.ijbiomac.2014.10.062
Cheong, K. L., Wu, D. T., Deng, Y., et al. Qualitation and quantification of specific polysaccharides from Panax species using GC-MS, saccharide mapping and HPSEC-RID-MALLS. Carbohydrate Polymers, 2016, 153: 47–54. https://doi.org/10.1016/j.carbpol.2016.07.077
Zhang, X., Li, S., Sun, L., et al. Further analysis of the structure and immunological activity of an RG-I type pectin from Panax ginseng. Carbohydrate Polymers, 2012, 89: 519–525. https://doi.org/10.1016/j.carbpol.2012.03.039
Fan, Y., Sun, L., Yang, S., et al. The roles and mechanisms of homogalacturonan and rhamnogalacturonan I pectins on the inhibition of cell migration. International Journal of Biological Macromolecules, 2017, 106: 207–217. https://doi.org/10.1016/j.ijbiomac.2017.08.004
Choi, K. J., Kim, D. H. Studies on the lipid components of fresh ginseng, red ginseng and white ginseng. Korean Journal of Pharmacognosy, 1985, 15: 141–150.
Pyo, M. K., Choi, S. H., Shin, T. J., et al. A simple method for the preparation of crude Gintonin from ginseng root, stem, and leaf. Journal of Ginseng Research, 2011, 35: 209–218. https://doi.org/10.5142/jgr.2011.35.2.209
Pyo, M. K., Choi, S. H., Hwang, S. H., et al. Novel glycolipoproteins from ginseng. Journal of Ginseng Research, 2011, 35: 92–103. https://doi.org/10.5142/jgr.2011.35.1.092
Choi, S. H., Jung, S. W., Lee, B. H., et al. Ginseng pharmacology: a new paradigm based on gintonin-lysophosphatidic acid receptor interactions. Frontier of Pharmacology, 2015, 27: 245. https://doi.org/10.3389/fphar.2015.00245
Kim, H. J., Jung, S. W., Kim, S. Y., et al. Panax ginseng as an adjuvant treatment for Alzheimer’s disease. Journal of Ginseng Research, 2018 , 42: 401–411. https://doi.org/10.1016/j.jgr.2017.12.008
Ikram, M., Ullah, R., Khan, A., et al. Ongoing research on the role of gintonin in the management of neurodegenerative disorders. Cells, 2020, 9: 1464. https://doi.org/10.3390/cells9061464
Jakaria, M., Azam, S., Go, E. A., et al. Biological evidence of gintonin efficacy in memory disorders. Pharmacology Research, 2021, 163: 105221. https://doi.org/10.1016/j.phrs.2020.105221
Choi, S. H., Lee, R., Nam, S. M., et al. Ginseng gintonin, aging societies, and geriatric brain diseases. Integrative Medicine Research, 2021, 10: 100450. https://doi.org/10.1016/j.imr.2020.100450
Lee, B. H., Choi, S. H., Kim, H. J., et al. Plant lysophosphatidic acids: a rich source for bioactive lysophosphatidic acids and their pharmacological applications. Biological & Pharmaceutical Bulletin, 2016, 39: 156–162. https://doi.org/10.1248/bpb.b15-00575
Chun, J., Hla, T., Lynch, K. R., et al. International union of basic and clinical pharmacology. LXXVIII. lysophospholipid receptor nomenclature. Pharmacology, 2010, 62: 579–587. https://doi.org/10.1124/pr.110.003111
Inoue, A., Ishiguro, J., Kitamura, H., et al. TGFa shedding assay: an accurate and versatile method for detecting GPCR activation. Natural Methods, 2012, 9: 1021–1029. https://doi.org/10.1038/nmeth.2172
Oka, S., Nakajima, K., Yamashita, A., et al. Identification of GPR55 as a lysophosphatidylinositol receptor. Biochemical and Biophysical Research Communications, 2007, 362: 928–934. https://doi.org/10.1016/j.bbrc.2007.08.078
Cho, Y. J., Choi, S. H., Lee, R., et al. Ginseng gintonin contains ligands for GPR40 and GPR55. Molecules, 2020, 25: 1102. https://doi.org/10.3390/molecules25051102
Kim, J. A., Son, J. H., Yang, S. Y., et al. Isoconiferoside, a new phenolic glucoside from seeds of Panax ginseng. Molecules (Basel, Switzerland):, 2011, 16: 6577–6581. https://doi.org/10.3390/molecules16086577
Ateeque, A., Seung-Hyun, K., Mohd, A., et al. New chemical constituents from Oryza sativa straw and their algicidal activities against blue-green algae, Journal of Agricultural Food Chemistry, 2013 , 61: 8039–8048. https://doi.org/10.1021/jf402145u
Murata, K., Iida, D., Ueno, Y., et al. Novel polyacetylene derivatives and their inhibitory activities on acetylcholinesterase obtained from Panax ginseng roots. Journal of Natural Medicines, 2017, 71: 114–122. https://doi.org/10.1007/s11418-016-1036-7
Huang, R., Zhang, M., Tong, Y., et al. Studies on bioactive components of red ginseng by UHPLC-MS and its effect on lipid metabolism of type 2 diabetes mellitus. Frontiers in Nutrition, 2022, 9: 865070. https://doi.org/10.3389/fnut.2022.865070
Chen, L. H., Zhang, Y. B., Yang, X. W., et al. Application of UPLC-Triple TOF-MS/MS metabolomics strategy to reveal the dynamic changes of triterpenoid saponins during the decocting process of Asian ginseng and American ginseng. Food Chemistry, 2023, 424: 136425. https://doi.org/10.1016/j.foodchem.2023.136425
Xu, J., Liu, H., Su, G., et al. Purification of ginseng rare sapogenins 25-OH-PPT and its hypoglycemic, antiinflammatory and lipid-lowering mechanisms. Journal of Ginseng Research, 2021, 45: 86–97. https://doi.org/10.1016/j.jgr.2019.11.002
Choi, S. H., Shin, T. J., Lee, B. H., et al. An edible gintonin preparation from ginseng. Journal of Ginseng Research, 2011, 35: 471–478. https://doi.org/10.5142/jgr.2011.35.4.471
Liu, R., Chen, Q. H., Ren, J. W., et al. Ginseng ( Panax ginseng Meyer) oligopeptides protect against binge drinking-induced liver damage through inhibiting oxidative stress and inflammation in rats. Nutrients, 2018, 10: 1665. https://doi.org/10.3390/nu10111665
Bao, L., Cai, X., Wang, J., et al. Anti-Fatigue effects of small molecule oligopeptides isolated from Panax ginseng C. A. Meyer in mice. Nutrients, 2016, 8: 807. https://doi.org/10.3390/nu8120807
Kim, T., Choi, H., Kim, N., et al. Anxiolytic-like effects of ginsenosides Rg3 and Rh2 from red ginseng in the elevated plus-maze model. Planta Medica, 2009, 75: 836–839. https://doi.org/10.1055/s-0029-1185402. Epub 2009 Mar 5. PMID: 19266429.
Eriksson, T. L., Svensson, S. P., Lundström, I., et al. Panax ginseng induces anterograde transport of pigment organelles in Xenopus melanophores. Journal of Ethnopharmacology, 2008 , 119: 17–23. https://doi.org/10.1016/j.jep.2008.05.024
Dascal, N. The use of Xenopus oocytes for the study of ion channels. CRC Critical Reviews in Biochemistry, 1987, 22: 317–387. https://doi.org/10.3109/10409238709086960
Yu, X., Feng, X., Zhang, J., et al. New progress in the study of chemical components and pharmacological effects of ginseng. Ginseng Research, 2019, 31: 47–51.
Shibata, S., Tanaka, O., Soma, K., et al. Studies on saponins and sapogenins of ginseng: the structure of panaxatriol. Tetrahedron Letters, 1965, 42: 207–213.
Kanzaki, T., Morisaki, N., Shiina, R., et al. Role of transforming growth factor-β pathway in the mechanism of wound healing by saponin from Ginseng Radix Rubra. British Journal of Pharmacology, 1998, 125: 255–262. https://doi.org/10.1038/sj.bjp.0702052
Wei, X. Y., Yang, J. Y., Wang, J. H., et al. Anxiolytic effect of saponins from Panax quinquefolium in mice. Journal of Ethnopharmacology, 2007, 111: 613–618. https://doi.org/10.1016/j.jep.2007.01.009
Tanaka, T., Kassai, A., Ohmoto, M., et al. Quantification of phosphatidic acid in foodstuffs using a thin-layer-chromatography-imaging technique. Journal of Agricultural and Food Chemistry, 2012, 60: 4156–4161. https://doi.org/10.1021/jf300147y
Irfan, M., Jeong, D., Saba, E., et al. Gintonin modulates platelet function and inhibits thrombus formation via impaired glycoprotein VI signaling. Platelets, 2019, 30: 589–598. https://doi.org/10.1080/09537104.2018.1479033
Akhter, F. K., Mumin, A. M., Lui, M. E., et al. Fabrication of fluorescent labeled ginseng polysaccharide nanoparticles for bioimaging and their immunomodulatory activity on macrophage cell lines. International Journal of Biological Macromolecules, 2018, 109: 254–262. https://doi.org/10.1016/j.ijbiomac.2017.12.050
Li, Y. P., Liu, J. P. Nutritional Components and Functional Factors of Ginseng. Chemical Industry Press, Beijing, 2017 .
[113]
Yao, M. J., Lü, J. P., Zhang, Q., et al. Research on the chemical components and pharmacological effects of ginseng. Jilin Traditional Chinese Medicine, 2017, 37: 1261–1263.
Gao, J., Lü, S. W. Research progress on chemical components and pharmacological effects of ginseng. Traditional Chinese Medicine Guide, 2021, 27: 127–130,137.
Shin, J. H., Kwon, H. W., Cho, H. J., et al. Vasodilator-stimulated phosphoprotein-phosphorylation by ginsenoside Ro inhibits fibrinogen binding to αIIb/β3 in thrombin-induced human platelets. Journal of Ginseng Research, 2016, 40: 359–365. https://doi.org/10.1016/j.jgr.2015.11.003
Luo, M., Yan, D. S., Sun, Q. S., et al. Ginsenoside Rg1 attenuates cardiomyocyte apoptosis and inflammation via the TLR4/NF-κB/NLRP3 pathway. Journal of Cellular Biochemistry, 2020, 121: 2994–3004. https://doi.org/10.1002/jcb.29556
Xiao, Q., Zhang, S. J., Yang, C., et al. Ginsenoside Rg1 ameliorates palmitic acid-induced hepatic steatosis and inflammation in HepG2 cells via the AMPK/NF-κB pathway. International Journal of Endocrinology, 2019, 2019: 7514802. https://doi.org/10.1155/2019/7514802
Sun, J. L., El-Aty, A., Ji, H. J., et al. Ginsenoside Rb2 ameliorates LPS-induced inflammation and ER stress in HUVECs and THP-1 cells via the AMPK-mediated pathway. The American Journal of Chinese Medicine, 2020, 48: 967–985. https://doi.org/10.1142/S0192415X20500469
Saba, E., Jeon, B. R., Jeong, D. H., et al. A novel korean red ginseng compound gintonin inhibited inflammation by MAPK and NF-κB pathways and recovered the levels of mir-34a and mir-93 in RAW 264.7 cells. Evidence-Based Complementary and Alternative Medicine: eCAM, 2015, 11: 624132. https://doi.org/10.1155/2015/624132
Jang, M., Min, J. L., Kim, C. S., et al. Korean red ginseng extract attenuates 3-nitropropionic acid-induced Huntington's-like symptoms. Evidence-Based Complementray and Alternative Medicine, 2013, 2013: 237207. https://doi.org/10.1155/2013/237207
Moon, J., Choi, S. H., Shim, J. Y., et al. Gintonin administration is safe and potentially beneficial in cognitively impaired elderly. Alzheimer Disease and Associated Disorders, 2018, 32: 85–87. https://doi.org/10.1097/WAD.0000000000000213
Shen, Y., Zhang, Q., Zhao, J. Q., et al Progress in the study of common pathological mechanisms between Alzheimer’s disease and Parkinson’s disease. Chinese Journal of Traditional Chinese Medicine, 2018 , 36: 319–322
[125]
Carolyn, H., Nancy, B., and Orly, L. Alzheimer’s disease and hippocampal adult neurogenesis; exploring shared mechanisms. Frontiers in Neuroscience, 2016, 10: 178. https://doi.org/10.3389/fnins.2016.00178
Hwang, S. H., Shin, E. J., Shin, T. J., et al. Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer’s disease-related neuropathies: involvement of non-amyloidogenic processing. Journal of Alzheimer’s Disease, 2012, 31: 207–223. https://doi.org/10.3233/JAD-2012-120439
Wang, Y., Zhao, W., Li, G., et al. Neuroprotective effect and mechanism of thiazolidinedione on dopaminergic neurons in vivo and in vitro in Parkinson’s disease. PPAR Research, 2017, 2017: 1–12. https://doi.org/10.1155/2017/4089214
Jo, M. G., Ikram, M., Jo, M. H., et al. Gintonin mitigates MPTP-induced loss of nigrostriatal dopaminergic neurons and accumulation of α-synuclein via the Nrf2/HO-1 pathway. Molecular Neurobiology, 2018, 56: 39–55.
Köhler, C. A., Freitas, T. H., Maes, M., et al. Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies. Acta Psychiatrica Scandinavica, 2017, 135: 373–387. https://doi.org/10.1111/acps.12698
Kim, H. J., Park, S. D., Lee, R. M., et al. Gintonin attenuates depressive-like behaviors associated with alcohol withdrawal in mice. Journal of Affective Disorders, 2017, 215: 23–29. https://doi.org/10.1016/j.jad.2017.03.026
National Pharmacopoeia Committee Pharmacopoeia of the People’s Republic of China: Volume 1. People Health Publishing House, Beijing, 1964 .
[134]
National Pharmacopoeia Committee Pharmacopoeia of the People’s Republic of China: Volume 1. People Health Publishing House, Beijing, 1978 .
[135]
National Pharmacopoeia Committee Pharmacopoeia of the People’s Republic of China: Volume 1. Hua Academic Press, People’s Health Press, Beijing, 1985 .
[136]
National Pharmacopoeia Committee Pharmacopoeia of the People’s Republic of China: Volume 1. Hua Academic Press, People’s Health Press, Beijing, 1990 .
[137]
National Pharmacopoeia Committee Pharmacopoeia of the People’s Republic of China: Volume 1. Hua Xuegong Press, Guangdong Science and Technology Press, Beijing, 1995 .
[138]
National Pharmacopoeia Committee Pharmacopoeia of the People’s Republic of China: Volume 1. Hua Academic Press, Beijing, 2000 .
[139]
National Pharmacopoeia Committee Pharmacopoeia of the People’s Republic of China: Volume 1. Hua Academic Press, Beijing, 2005 .
[140]
National Pharmacopoeia Committee Pharmacopoeia of the People’s Republic of China: Volume 1. Central National Medical Science and Technology Press, Beijing, 2010 .
[141]
National Pharmacopoeia Committee Pharmacopoeia of the People’s Republic of China: Volume 1. Central National Medical Science and Technology Press, Beijing, 2015 .
[142]
National Pharmacopoeia Committee Pharmacopoeia of the People’s Republic of China: Volume 1. Central National Medical Science and Technology Press, Beijing, 2020 .
[143]
Yeo, C. R., Yong, J. J., Popovich, D. G. Isolation and characterization of bioactive polyacetylenes Meyer roots. Journal of Pharmaceutical and Biomedical Analysis, 2017, 139: 148–155. https://doi.org/10.1016/j.jpba.2017.02.054
Xu, X. F., Gao, Y., Xu, S. Y., et al. Remarkable impact of steam temperature on ginsenosides transformation from fresh ginseng to red ginseng. Journal of Ginseng Research, 2018, 42: 277–287. https://doi.org/10.1016/j.jgr.2017.02.003
Sun, B. S., Xu, M. Y., Li, Z., Wang, Y. B., et al. UPLC-Q-TOF-MS/MS analysis for steaming times-dependent profiling of steamed Panax quinquefolius and its ginsenosides transformations induced by repetitious steaming. Journal of Ginseng Research, 2012, 36: 277–290. https://doi.org/10.5142/jgr.2012.36.3.277
Koh, E., Jang, O. H., Hwang, K. H., et al. Effects of steaming and air-drying on ginsenoside composition of Korean ginseng ( Panax ginseng C.A. Meyer). Journal of Food Processing and Preservation, 2015, 39: 207–213. https://doi.org/10.1111/jfpp.12412
Chen, W., Balan, P., Popovich, D. G. Changes of ginsenoside composition in the creation of black ginseng leaf. Molecules (Basel, Switzerland), 2020, 25: 2809. https://doi.org/10.3390/molecules25122809
Huang, X., Liu, Y., Zhang, Y., et al. Multicomponent assessment and ginsenoside conversions of Panax quinquefolium L. roots before and after steaming by HPLC-MSn. Journal of Ginseng Research, 2017, 43: 27–37. https://doi.org/10.1016/j.jgr.2017.08.001
Wang, D., Liao P. Y., Zhu, H. T., et al. The processing of Panax notoginseng and the transformation of its saponin components. Food Chemistry, 2012, 132: 1808–1813. https://doi.org/10.1016/j.foodchem.2011.12.010
Zhou, S. S., Xu, J., Kong, M., et al. Synchronous characterization of carbohydrates and ginsenosides yields deeper insights into the processing chemistry of ginseng. Journal of Pharmaceutical and Biomedical Analysis, 2017, 145: 59–70. https://doi.org/10.1016/j.jpba.2017.06.042
Liu, Z., Xia, J., Wang, C. Z., et al. Remarkable impact of acidic ginsenosides and organic acids on ginsenoside transformation from fresh ginseng to red ginseng. Journal of Agricultural and Food Chemistry, 2016, 64: 5389–5399. https://doi.org/10.1021/acs.jafc.6b00963
Jin, Y., Kim, Y. J., Jeon, J. N., et al. Effect of white, red and black ginseng on physicochemical properties and ginsenosides. Plant Foods for Human Nutrition (Dordrecht, Netherlands), 2015, 70: 141–145. https://doi.org/10.1007/s11130-015-0470-0
Palaniyandi, A. S., Son, M. B., Damodharan, K., et al. Fermentative transformation of ginsenoside Rb1 from Panax ginseng C. A. Meyer to Rg3 and Rh2 by Lactobacillus paracasei subsp. tolerans MJM60396. Biotechnology and Bioprocess Engineering, 2016, 21: 587–594. https://doi.org/10.1007/s12257-016-0281-7
Biswas, T., Dwivedi, U. N. Plant triterpenoid saponins: biosynthesis, in vitro production, and pharmacological relevance. Protoplasma, 2019, 256: 1463–1486. https://doi.org/10.1007/s00709-019-01411-0
Stermer, B. A., Bianchini, G. M., Korth, K. L. Regulation of HMG-CoA reductase activity in plants. Journal of Lipid Research, 1994, 35: 1133–1140. https://doi.org/10.1016/S0022-2275(20)39958-2
Sandmann, G., Albrecht, M. Light-Stimulated carotenoid biosynthesis during transformation of maize etioplasts is regulated by increased activity of isopentenyl pyrophosphate isomerase. Plant physiology, 1994, 92: 297–301.
Zhao, Y. J., Li, C. Biosynthesis of plant triterpenoid saponins in microbial cell factories. Journal of Agricultural and Food Chemistry, 2018, 66: 12155–12165. https://doi.org/10.1021/acs.jafc.8b04657
Felix, J. S., Jordi, P. G., Lorenzo C. P., et al. A new family of enzymes catalyzing the first committed step of the methylerythritol 4-phosphate (MEP) pathway for isoprenoid biosynthesis in bacteria. Proceedings of the National Academy of Sciences of the United States of America, 2010, 107: 14081–14086. https://doi.org/10.1073/pnas.1001962107
Liu, W., Li, W. Development status and the prospect of ginseng processing and industrialization in China. Journal of Jilin Agricultural University, 2023, 45: 639.
Li, X. M., Gao, Q. Q., Zhao, Y. Q., et al. Research progress of ginseng extracts and saponin components in skin care and hair care. Chinese Herbal Medicine, 2021, 52: 5078.
Zhang Z-B, Yu C-Y, Wang H-Y, et al. The history, beneficial ingredients, mechanism, processing, and products of Panax ginseng for medicinal and edible value. Food & Medicine Homology, 2025,https://doi.org/10.26599/FMH.2025.9420059