Quorum sensing inhibitor: an effective strategy to attenuate the virulence and drug resistance of <i>Pseudomonas aeruginosa</i>

Jin-Fang Zhou; Zhe-Wen Liang; Kun-Yuan Yin; Ying Wang; Wen Li; Tao Wang; Hong Chen; Xiao-Juan Tan; Mohsin Tanveer; Jin-Wei Zhou; Zhi-Yong Guo

doi:10.26599/FMH.2025.9420066

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Open Access | Online First

Quorum sensing inhibitor: an effective strategy to attenuate the virulence and drug resistance of Pseudomonas aeruginosa

Jin-Fang Zhou^¹, Zhe-Wen Liang^², Kun-Yuan Yin^², Ying Wang^², Wen Li^², Tao Wang^², Hong Chen^³(), Xiao-Juan Tan^⁴(), Mohsin Tanveer^⁵, Jin-Wei Zhou^²(), Zhi-Yong Guo^¹()

1College of Biological & Pharmaceutical Sciences, China Three Gorges University

2School of Food and Biological Engineering, Xuzhou University of Technology, Xuzhou 221018, China

3Luoyang Key Laboratory of Organic Functional Molecules, College of Food and Drug, Luoyang Normal University, Luoyang 471934, China

4Anhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Diseases, Anhui Normal University, Wuhu 241000, China

5Tasmanian Institute of Agriculture, University of Tasmania Australia, Hobart 7270, Australia

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Highlights

(1) Pseudomonas aeruginosa is contributor to food spoilage and foodborne diseases.

(2) The pathogenicity and drug resistance of P. aeruginosa is related to quorum sensing.

(3) Quorum sensing inhibitor could reduce the drug resistance of P. aeruginosa.

Graphical Abstract

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The synthesis of pyocyanin begins with chorismic acid. Chorismic acid is converted to phenazine-1-carboxylic acid through the action of gene clusters phz1 and phz2 and subsequently converted into pyocyanin catalyzed by PhzM and PhzS.

Abstract

Pseudomonas aeruginosa is a significant contributor to food spoilage and foodborne diseases. The primary strategy for preventing and controlling contamination by P. aeruginosa involves the application of antibacterial agents. However, the overuse or abuse of antimicrobial agents has accelerated the development of drug resistance. The control of spoilage and antimicrobial resistance in P. aeruginosa has emerged as a major food safety challenge. Numerous studies have established that the pathogenicity and drug resistance of P. aeruginosa are regulated by quorum sensing (QS). Therefore, inhibiting the QS system of P. aeruginosa is a promising approach to mitigate the pathogenicity and resistance of this pathogen. This review explores various QS systems of P. aeruginosa and their roles in bacterial pathogenesis and drug resistance. Additionally, it discusses the potential of small chemical molecules and quorum-quenching enzymes in attenuating the pathogenesis of P. aeruginosa, as well as the possibility of using QS inhibitors (QSIs) and antibiotics in future therapeutic approaches for P. aeruginosa-associated infections.

Keywords

Pseudomonas aeruginosaquorum sensing virulence factor food spoilage drug resistance

References

[1]

Bai, L., Liu, M., Sun, Y. Overview of food preservation and traceability technology in the smart cold chain system. Foods, 2023, 12: 2881. https://doi.org/10.3390/foods12152881

Genes	Virulence factors	Effect on host	Effect on P. aeruginosa	References
lasA	Protease	Disruption of host complement proteins	Host immune evasion	[23]
lasB	Elastase	Degradation of matrix proteins	Iron acquisition	[24]
phzABCDEFG, phzM	Pyocyanin	Inhibit epidermal cell growth and cause oxidative stress	Drug resistance and enhanced colonization	[25, 26]
rhlA, rhlB	Rhamnolipid	Neutrophil necrosis	Immune evasion and enhanced infection	[41]
lpxD	Lipopolysaccharide	Inflammation and immune rejection response	Drug resistance	[45, 46]
PA3540-3551	Alginate	Affect cell-to-cell communication	Drug resistance and enhanced colonization	[47]