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Research Article | Open Access

Immune-boosting effects of nutritional formulations containing acerola cherries extractive and lactoferrin

Haifu Jia1,§, Yuhong Wang1,§, Yueming Zhao2,3, Ziyu Hu1, Qingjing Liu2,3, Yanmei Hou2,3, Yujun Jiang1, Qianyu Zhao1( ), Chaoxin Man1( )
Key Laboratory of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin 150030, China
Ausnutria Dairy (China) Co., Ltd., Changsha 410000, China
Aunulife Biotechnology Co., Ltd., Changsha 410000, China

§These authors contributed equally to this work.

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Abstract

Reduced immunity can harm the health of the organism, and nowadays, improving immunity is getting more and more attention, so the nutrients with immune boosting function (acerola cherry, taurine, zinc gluconate, and lactoferrin) are compounded in the best ratio to develop a nutritional formula food, and evaluated by cellular immunity, humoral immunity, non-specific immunity. In this study, an immunocompromised mice model was established using cyclophosphamide (CTX), the ability and difference of different components to enhance the immunity of mice were determined by the gavage of different components. The results showed that the nutritional formula food could recover the body weight of immunocompromised mice, promote the development of immune organs in immunocompromised mice, enhance the delayed-type hypersensitivity (DTH) response, the ability to produce serum hemolysin and the phagocytosis of monocytes in immunocompromised mice, and increase the levels of immunoglobulin A (IgA), IgG and IgM in the serum of immunocompromised mice. It has proved that this nutritional formula food (containing acerola cherry, taurine, zinc gluconate, and lactoferrin) has synergistic effect and can work together on humoral immunity, cellular immunity and non-specific immunity to improve the immune resistance of mice, and has promising application.

Keywords

immunityacerola cherrylactoferrinnutrition formulation

References

[1]
D. Gao, Z. J. Liu, F. Liu, et al., Study of the immunoregulatory effect of Lactobacillus rhamnosus 1.0320 in immunosuppressed mice, J. Funct. Foods 79 (2021) 104423. https://doi.org/10.1016/j.jff.2021.104423.
Crossref
[2]

M. G. Netea, J. Dominguez-Andres, L. B. Barreiro, et al., Defining trained immunity and its role in health and disease, Nat. Rev. Immunol. 20 (2020) 375–388. https://doi.org/10.1038/s41577-020-0285-6.
Crossref Google Scholar
[3]

K. J. Kaczorowski, K. Shekhar, D. Nkulikiyimfura, et al., Continuous immunotypes describe human immune variation and predict diverse responses, Proc. Natl. Acad. Sci. 114 (2017) E6097–E6106. https://doi.org/10.1073/pnas.1705065114.
Crossref Google Scholar
[4]

G. J. Ding, J. Bai, B. H. Feng, et al., An EGFP-marked recombinant Lactobacillus oral tetravalent vaccine constitutively expressing alpha, epsilon, beta 1, and beta 2 toxoids for Clostridium perfringens elicits effective anti-toxins protective immunity, Virulence 10 (2019) 754–767. https://doi.org/10.1080/21505594.2019.1653720.
Crossref Google Scholar
[5]

X. W. Li, B. Z. Zhang, D. S. Zhang, et al., The construction of recombinant Lactobacillus casei vaccine of PEDV and its immune responses in mice, BMC Vet. Res. 17 (2021) 1–10. https://doi.org/10.1186/s12917-021-02885-y.
Crossref Google Scholar
[6]

H. T. Huang, Y. F. Hu, B. H. Lee, et al., Dietary of Lactobacillus paracasei and Bifidobacterium longum improve nonspecific immune responses, growth performance, and resistance against Vibrio parahaemolyticus in Penaeus vannamei, Fish Shellfish Immunol. 128 (2022) 307–315. https://doi.org/10.1016/j.fsi.2022.07.062.
Crossref Google Scholar
[7]

K. Adel-Patient, M. Guinot, B. Guillon, et al., Administration of extensive hydrolysates from caseins and Lactobacillus rhamnosus GG probiotic does not prevent cow’s milk proteins allergy in a mouse model, Front. Immunol. 11 (2020) 1700. https://doi.org/10.3389/fimmu.2020.01700.
Crossref Google Scholar
[8]

J. M. Huang, J. S. Yang, K. Tang, et al., A study on the factors influencing the preservation rate of ascorbic acid in acerola cherry pulp, Food Sci. Technol. 42 (2022) e16322. https://doi.org/10.1590/ fst.16322.
Crossref Google Scholar
[9]

V. V. De Rosso, A. Z. Mercadante, Carotenoid composition of two Brazilian genotypes of acerola ( Malpighia punicifolia L.) from two harvests, Food Res. Int. 38 (2005) 1073–1077. https://doi.org/10.1016/j.foodres.2005.02.023.
Crossref Google Scholar
[10]

A. A. Badejo, S. T. Jeong, N. Goto-Yamamoto, et al., Cloning and expression of GDP- D-mannose pyrophosphorylase gene and ascorbic acid content of acerola ( Malpighia glabra L.) fruit at ripening stages, Plant Physiol. Biochem. 45 (2007) 665–672. https://doi.org/10.1016/j.plaphy.2007.07.003.
Crossref Google Scholar
[11]

R. D. Nunes, V. F. S. Kahl, M. D. Sarmento, et al., Antigenotoxicity and antioxidant activity of acerola fruit ( Malpighia glabra L.) at two stages of ripeness, Plant Foods Hum. Nutr. 66 (2011) 129–135. https://doi.org/10.1007/s11130-011- 0223-7.
Crossref Google Scholar
[12]

Y. Rezende, J. P. Nogueira, N. Narain, Microencapsulation of extracts of bioactive compounds obtained from acerola ( Malpighia emarginata DC) pulp and residue by spray and freeze drying: chemical, morphological and chemometric characterization, Food Chem. 254 (2018) 281–291. https://doi.org/10.1016/j.foodchem.2018.02.026.
Crossref Google Scholar
[13]
R. Olędzki, J. Harasym, Acerola (Malpighia emarginata) anti-inflammatory activity: a review, Int. J. Mol. Sci. (2024) 2089. https://doi.org/10.3390/ijms25042089.
Crossref
[14]

S. S. El-Hawary, R. A. El-Fitiany, O. M. Mousa, et al., Metabolic profiling and in vivo hepatoprotective activity of Malpighia glabra L. leaves, J. Food Biochem. 45(2) (2020) e13588. https://doi.org/10.1111/jfbc.13588.
Crossref Google Scholar
[15]

T. T. Dai, D. J. McClements, T. Hu, et al., Improving foam performance using colloidal protein-polyphenol complexes: lactoferrin and tannic acid, Food Chem. 377 (2022) 131950. https://doi.org/10.1016/j.foodchem.2021.131950.
Crossref Google Scholar
[16]

Š. Gruden, N. Poklar Ulrih, Diverse mechanisms of antimicrobial activities of lactoferrins, lactoferricins, and other lactoferrin-derived peptides, Int. J. Mol. Sci. 22 (2021) 11264. https://doi.org/10.3390/ijms222011264.
Crossref Google Scholar
[17]

D. Legrand, Overview of lactoferrin as a natural immune modulator, J. Pediatr. 173 (2016) S10–S15. https://doi.org/10.1016/j.jpeds.2016.02.071.
Crossref Google Scholar
[18]

W. Li, K. Fu, X. Lü, et al., Lactoferrin suppresses lipopolysaccharide-induced endometritis in mice via down-regulation of the NF-κB pathway, Int. Immunopharmacol. 28 (2015) 695–699. https://doi.org/10.1016/j.intimp.2015.07.040.
Crossref Google Scholar
[19]

E. Elass-Rochard, A. Roseanu, D. Legrand, et al., Lactoferrin-lipopolysaccharide interaction: involvement of the 28-34 loop region of human lactoferrin in the high-affinity binding to Escherichia coli 055B5 lipopolysaccharide, Biochem. J. 312 (1995) 839–845. https://doi.org/10.1042/bj3120839.
Crossref Google Scholar
[20]

P. Hu, F. Zhao, J. Wang, et al., Lactoferrin attenuates lipopolysaccharide-stimulated inflammatory responses and barrier impairment through the modulation of NF-κB/MAPK/Nrf2 pathways in IPEC-J2 cells, Food Funct. 11 (2020) 8516–8526. https://doi.org/10.1039/d0fo01570a.
Crossref Google Scholar
[21]

C. Guo, Z. H. Yang, S. Zhang, et al., Intranasal lactoferrin enhances α-secretase-dependent amyloid precursor protein processing via the ERK1/2-CREB and HIF-1α pathways in an Alzheimer’s disease mouse model, Neuropsychopharmacology 42 (2017) 2504–2515. https://doi.org/10.1038/npp.2017.8.
Crossref Google Scholar
[22]

Z. Hu, N. Li, C. Liu, et al., Evaluation on immune-enhancement effect of lactoferrin, Food Sci. 31 (2010) 244–247.
Google Scholar
[23]

Z. Hao, J. Yang, K. Xiao, et al., Taurine: physiological function and application in pig production, Chin. J. Anim. Nutr. 30 (2018) 2050–2056.
Google Scholar
[24]

C. J. Jong, P. Sandal, S. W. Schaffer, The role of taurine in mitochondria health: more than just an antioxidant, Molecules 26 (2021) 4913. https://doi.org/10.3390/molecules26164913.
Crossref Google Scholar
[25]

N. Ma, F. He, J. Kawanokuchi, et al., Taurine and its anticancer functions: in vivo and in vitro study, Adv. Exp. Med. Biol. 1370 (2022) 121–128. https://doi.org/10.1007/978-3-030-93337-1_11.
Crossref Google Scholar
[26]

F. He, N. Ma, K. Midorikawa, et al., Taurine exhibits an apoptosis-inducing effect on human nasopharyngeal carcinoma cells through PTEN/Akt pathways in vitro, Amino Acids 50 (2018) 1749–1758. https://doi.org/10.1007/s00726-018-2651-2.
Crossref Google Scholar
[27]

Y. Ping, J. Shan, Y. Liu, et al., Taurine enhances the antitumor efficacy of PD-1 antibody by boosting CD8+ T cell function, Cancer Immunol. Immunother. 72 (2022) 1015–1027. https://doi.org/10.1007/s00262-022-03308-z.
Crossref Google Scholar
[28]

N. Z. Gammoh, L. Rink, Zinc in infection and inflammation, Nutrients 9 (2017) 624. https://doi.org/10.3390/nu9060624.
Crossref Google Scholar
[29]

S. Thomas, D. Patel, B. Bittel, et al., Effect of high-dose zinc and ascorbic acid supplementation vs usual care on symptom length and reduction among ambulatory patients With SARS-CoV-2 infection the COVID A to Z randomized clinical trial, JAMA Network Open 4 (2021) e210369. https://doi.org/10.1001/ jamanetworkopen.2021.0369.
Crossref Google Scholar
[30]

M. Andriollo-Sanchez, R. Claeyssen, J. Arnaud, et al., Toxic effects of iterative intraperitoneal administration of zinc gluconate in rats, Basic Clin. Physiol. Pharmacol. 103 (2008) 267–272. https://doi.org/10.1111/j.1742-7843.2008.00278.x.
Crossref Google Scholar
[31]

R. Duan, H. Zhang, L. Wu, et al., Effects of earthworm protein extract on intestinal mucosal immune function in immunosuppressed mice, J. Yunnan Agric. Univ. 37 (2022) 597–603.
Google Scholar
[32]

J. D. Wang, L. Wang, S. Yu, et al., Condensed Fuzheng extract increases immune function in mice with cyclophosphamide-induced immunosuppression, Food Sci. Nutr. 10 (2022) 3865–3875. https://doi.org/10.1002/fsn3.2982.
Crossref Google Scholar
[33]
Y. L. Song, M. Y. Sun, F. L. Ma, et al., Lactiplantibacillus plantarum DLPT4 protects against cyclophosphamide-induced immunosuppression in mice by regulating immune response and intestinal flora, Probiotics Antimicrob. Proteins (2023) 1–13. https://doi.org/10.1007/s12602-022-10015-9.
Crossref
[34]

E. J. Kooistra, S. Brinkman, P. H. J. van der Voort, et al., Body mass index and mortality in coronavirus disease 2019 and other diseases: a cohort study in 35 506 ICU Patients, Crit. Care Med. 50 (2022) E1–E10. https://doi.org/10.1097/ccm.0000000000005216.
Crossref Google Scholar
[35]

L. Q. Zang, L. A. Maddison, W. B. Chen, Zebra fish as a model for obesity and diabetes, Front. Cell Dev. Biol. 6 (2018) 91. https://doi.org/10.3389/fcell.2018.00091.
Crossref Google Scholar
[36]

F. Q. Pan, H. T. Du, W. G. Tian, et al., Effect of GnRH immunocastration on immune function in male rats, Front. Immunol. 13 (2023) 1023104. https://doi.org/10.3389/fimmu.2022.1023104.
Crossref Google Scholar
[37]

Q. Li, G. Y. Chen, H. Chen, et al., Se-enriched G-frondosa polysaccharide protects against immunosuppression in cyclophosphamide-induced mice via MAPKs signal transduction pathway, Carbohydr. Polym. 196 (2018) 445–456. https://doi.org/10.1016/j.carbpol.2018.05.046.
Crossref Google Scholar
[38]

Y. Ding, Y. M. Yan, D. Chen, et al., Modulating effects of polysaccharides from the fruits of Lycium barbarum on the immune response and gut microbiota in cyclophosphamide-treated mice, Food Funct. 10 (2019) 3671–3683. https://doi.org/10.1039/c9fo00638a.
Crossref Google Scholar
[39]

W. Liu, Y. Ji, B. Pi, et al., Effect of Dregea sinensis extract on delayed type hypersensitivity of mouse, J. Gansu Agric. Univ. 55 (2020) 13–19.
Google Scholar
[40]

S. Abid, A. Khajuria, Q. Parvaiz, et al., Immunomodulatory studies of a bioactive fraction from the fruit of Prunus cerasus in BALB/c mice, Int. Immunopharmacol. 12 (2012) 626–634. https://doi.org/10.1016/j.intimp.2012.02.001.
Crossref Google Scholar
[41]

W. Ma, W. Li, Q. Ma, et al., Effects of Bifidobacterium lactis XLTG11 on immune function in mice, Food Ferment. Ind. 48 (2022) 103–107.
Google Scholar
[42]
D. Liu, J. Lu, Y. Lu, et al., The immunomodulatory effects of Lactobacillus rhamnosus LV108 and its fermented milk, Chin. J. Microecol. 32 (2020) 1365–1369; 1378.
[43]

H. Kumar, N. Vasudeva, Immunomodulatory potential of Nyctanthes abrortristis stem bark, J. Ayurveda Integr. Med. 13 (2022) 100556. https://doi.org/10.1016/j.jaim.2022.100556.
Crossref Google Scholar
[44]

L. P. Nudo, E. S. Catap, Immunostimulatory effects of Uncaria perrottetii (A. Rich. ) Merr. (Rubiaceae) vinebark aqueous extract in Balb/C mice, J. Ethnopharmacol. 133 (2011) 613–620. https://doi.org/10.1016/j.jep.2010.10.044.
Crossref Google Scholar
[45]

T. Sidiq, A. Khajuria, P. Suden, et al., Possible role of macrophages induced by an irridoid glycoside (RLJ-NE-299A) in host defense mechanism, Int. Immunopharmacol. 11 (2011) 128–135. https://doi.org/10.1016/j.intimp.2010.10.017.
Crossref Google Scholar
[46]

Z. Chen, W. Wei, D. Chen, et al., Effect of vancoglycosamine on vancomycin-induced phagocytosis in mouse macrophages RAW264.7, Chin. J. New Drugs. 29 (2020) 1040–1044.
Google Scholar
[47]
T. H. Kim, S. J. Lee, H. K. Rim, et al., In vitro and in vivo immunostimulatory effects of hot water extracts from the leaves of Artemisia princeps Pampanini cv. Sajabal, J. Ethnopharmacol. 149 (2013) 254–262. https://doi.org/10.1016/j.jep.2013.06.030.
Crossref
[48]

J. Shi, Q. Zhang, X. H. Zhao, et al., The impact of caseinate oligochitosan-glycation by transglutaminase on amino acid compositions and immune-promoting activity in BALB/c mice of the tryptic caseinate hydrolysate, Food Chem. 350 (2021) 129302. https://doi.org/10.1016/j.foodchem.2021.129302.
Crossref Google Scholar
[49]

H. Wei, J. Y. Wang, Role of polymeric immunoglobulin receptor in IgA and IgM transcytosis, Int. J. Mol. Sci. 22 (2021) 2284. https://doi.org/10.3390/ijms22052284.
Crossref Google Scholar
Food Science of Animal Products
Volume 2 Issue 1,
March 2024
Article number: 9240055
DOI: 10.26599/FSAP.2024.9240055
Cite this article:
Jia H, Wang Y, Zhao Y, et al. Immune-boosting effects of nutritional formulations containing acerola cherries extractive and lactoferrin. Food Science of Animal Products, 2024, 2(1): 9240055. https://doi.org/10.26599/FSAP.2024.9240055

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Received: 20 April 2024
Revised: 28 April 2024
Accepted: 06 May 2024
Published: 30 May 2024
© Beijing Academy of Food Sciences 2024.

Food Science of Animal Products published by Tsinghua University Press. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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