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Review Article | Open Access

Effects of enzymolysis on allergenicity and digestibility of food allergens

Jing Yang1,2(), Shuling Zhou1, Yan Chen1, Jiajia Song3, Jiawang Jin1, Ruiping Gao1,2
School of Food Science and Engineering, Chongqing Technology and Business University, Chongqing 400067, China
Modern Industry Faculty of Food Nutrition and Health (Hot Pot), Chongqing Technology and Business University, Chongqing 400067, China
College of Food Science, Southwest University, Chongqing 400715, China
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Abstract

Food allergens are a significant concern for global public health. Enzymolysis, which includes enzymatic hydrolysis and enzymatic cross-linking, is known for its mild conditions, as well as its high efficiency and stability, making it a widely employed method to reduce the allergenicity of food proteins. A small group of eight foods-four of animal origin (milk, eggs, fish, and crustacean shellfish) and four of plant origin (tree nuts, peanuts, wheat, and soybeans) accounts for approximately 90% of all food allergies. However, there has been no comprehensive summary of how enzymolysis impacts the digestibility and allergenicity of these eight key foods, based on both in vitro and in vivo studies. This paper seeks to provide a systematic review of the influence of enzymolysis on food allergenicity, with a focus on molecular characteristics, epitopes, immunoglobulin (Ig) E/IgG binding capacity, and digestive stability during in vitro digestion. The potential immune regulation effects of enzymolysis products in cell and animal allergy models are also highlighted.

Keywords

enzymatic hydrolysisenzymatic cross-linkingallergensin vitro digestion

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Food Science of Animal Products
Volume 2 Issue 3,
September 2024
Article number: 9240082
DOI: 10.26599/FSAP.2024.9240082
Cite this article:
Yang J, Zhou S, Chen Y, et al. Effects of enzymolysis on allergenicity and digestibility of food allergens. Food Science of Animal Products, 2024, 2(3): 9240082. https://doi.org/10.26599/FSAP.2024.9240082
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