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Research Article | Open Access

Higher intakes of lysine, threonine and valine are inversely associated with non-alcoholic fatty liver disease risk: a community-based case-control study in the Chinese elderly

Xueqi Lia,, Wenjun Maa, Ting Yanga, Chong Wanga, Wei Zhangb, Hui Lib, Ting Zhaob, Xiaofei Guoa( )
Institute of Nutrition & Health, School of Public Health, Qingdao University, Qingdao 260071, China
Affiliated Hospital of Qingdao University, Qingdao 260071, China

Peer review under responsibility of Tsinghua University Press.

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Abstract

The associations of individual amino acid with non-alcoholic fatty liver disease (NAFLD) risk remained unclear. The present study aimed to investigate the associations between the two in the Chinese elderly. Methods: A community-based health check-up program was conducted in Qingdao, China. NAFLD was diagnosed by ultrasonography accompanied by epidemiological investigation. The dietary intakes of amino acids were investigated with 3-day, 24-h dietary records and calculated by Nutrition Calculator software. Restricted cubic spline model was used to evaluate a nonlinear relationship between amino acid intake and NAFLD risk. Results: 400 NAFLD subjects were identified, and 400 participants were randomly selected as controls and matched by gender and age (± 3 years) Dose-response analysis showed that 1000 mg increment of aromatic amino acids (AAAs) was associated with reduced 16% risk of NAFLD. Dietary increments of 750 mg/d threonine, 950 mg/d valine, or 1700 mg/d lysine were associated with a 20% reduction in the NAFLD risk (all P for linearity < 0.05). Conclusion: The present study demonstrated that the dietary increases in milk, eggs and deep-sea fish, which are rich in the amino acids, might contribute to protecting against NAFLD in the elderly.

Keywords

Amino acidNon-alcoholic fatty liver diseaseSenior citizenDose-response analysis

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Food Science and Human Wellness
Volume 13 Issue 1,
January 2024
Pages 191-197
DOI: 10.26599/FSHW.2022.9250016
Cite this article:
Li X, Ma W, Yang T, et al. Higher intakes of lysine, threonine and valine are inversely associated with non-alcoholic fatty liver disease risk: a community-based case-control study in the Chinese elderly. Food Science and Human Wellness, 2024, 13(1): 191-197. https://doi.org/10.26599/FSHW.2022.9250016

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Received: 07 January 2022
Revised: 15 March 2022
Accepted: 18 April 2022
Published: 01 June 2023
© 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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