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Open Access

Sugarcane leaves-derived polyphenols alleviate metabolic syndrome and modulate gut microbiota of ob/ob mice

Li Suna,b,1,, Tao Wanga,b,1, Baosong Chena,b, Cui Guoa,b, Shanshan Qiaoa,b, Jinghan Lina,b, Huan Liaoa,b, Huanqin Daia,b, Bin Wangc, Jingzu Suna( ), Hongwei Liua,b( )
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Savaid Medicine School, University of Chinese Academy of Sciences, Beijing 100101, China
Guangxi Academy of Sciences, Nanning 530007, China

1 These authors contributed equally.

Peer review under responsibility of Tsinghua University Press.

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Abstract

Sugarcane leaves-derived polyphenols (SLP) have been demonstrated to have diverse health-promoting benefits, but the mechanism of action has not been fully elucidated. This study aimed to investigate the anti-metabolic disease effects of SLP and the underlying mechanisms in mice. In the current study, we prepared the SLP mainly consisting of three flavonoid glycosides, three phenol derivatives, and two lignans including one new compound, and further demonstrated that SLP reduced body weight gain and fat accumulation, improved glucose and lipid metabolism disorders, ameliorated hepatic steatosis, and regulated short-chain fatty acids (SCFAs) production and secondary bile acids metabolism in ob/ob mice. Notably, SLP largely altered the gut microbiota composition, especially enriching the commensal bacteria Akkermansia muciniphila and Bacteroides acidifaciens. Oral gavage with the above two strains ameliorated metabolic syndrome (MetS), regulated secondary bile acid metabolism, and increased the production of SCFAs in high-fat diet (HFD)-induced obese mice. These results demonstrated that SLP could be used as a prebiotic to attenuate MetS via regulating gut microbiota composition and further activating the secondary bile acids-mediated gut-adipose axis.

Keywords

Metabolic syndromeAkkermansia muciniphilaSugarcane leaves-derived polyphenolsBacteroides acidifaciensSecondary bile acids metabolism

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Food Science and Human Wellness
Volume 13 Issue 2,
March 2024
Pages 633-648
DOI: 10.26599/FSHW.2022.9250048
Cite this article:
Sun L, Wang T, Chen B, et al. Sugarcane leaves-derived polyphenols alleviate metabolic syndrome and modulate gut microbiota of ob/ob mice. Food Science and Human Wellness, 2024, 13(2): 633-648. https://doi.org/10.26599/FSHW.2022.9250048

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Received: 05 July 2022
Revised: 22 August 2022
Accepted: 21 September 2022
Published: 25 September 2023
© 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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