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Open Access

The human-derived novel gut commensal Luoshenia tenuis regulates body weight and food intake in mice

Yu Jianga, Mengxuan Dua, Lisheng Xiec, Minzhi Jianga, Yaokun Zhanga, Mingxia Bia, Chang Liua,b( ), Hongwei Liud, Shuangjiang Liua,b( )
State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
College of Life Science, Hebei University, Baoding 071000, China
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

Peer review under responsibility of Tsinghua University Press.

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Abstract

Many studies have revealed that gut microbes modulate host metabolism. In this study, we characterized the therapeutic effects of a novel gut commensal Luoshenia tenuis against host metabolic disorders. First, by in silico analysis, we demonstrated that the L. tenuis was prevalent in the gut microbiomes of healthy humans but were depleted specif ically in obesity cohorts. Further in vitro cultivation revealed that L. tenuis produced short chain fatty acids that were verif ied to modulate host metabolism and some other volatile metabolites to benef it hosts by anti-inf lammation and anti-tumor. Second, gavage of the L. tenuis signif icantly decreased the body weight gain and food intake of high-fat diet-feeding C57BL/6J mice, which was in parallel with the changed expression level of genes related to satiety and feeding behavior. We then performed the gavage trial using diet induced obese mice, and it revealed that the administration of L. tenuis alleviated signif icantly the abnormal glucose and lipid metabolisms and reduced the inf lammatory response. In summary, this study revealed a previously-unknown human gut commensal microbe that benef ited host metabolism, and set the stage for the development of novel next-generation probiotic applicable for treatment of obesity and related metabolic disorders.

Keywords

Luoshenia tenuisGut microbeFeeding behaviorObesityNext-generation probiotic

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Food Science and Human Wellness
Volume 13 Issue 2,
March 2024
Pages 830-841
DOI: 10.26599/FSHW.2022.9250071
Cite this article:
Jiang Y, Du M, Xie L, et al. The human-derived novel gut commensal Luoshenia tenuis regulates body weight and food intake in mice. Food Science and Human Wellness, 2024, 13(2): 830-841. https://doi.org/10.26599/FSHW.2022.9250071

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Received: 23 June 2022
Revised: 09 November 2022
Accepted: 09 November 2022
Published: 25 September 2023
© 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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