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Review Article | Open Access

Food-derived protein hydrolysates and peptides: anxiolytic and antidepressant activities, characteristics, and mechanisms

Wenhui Li,, Yu Xi, Junru Wang, Yinxiao Zhang, He Li( ), Xinqi Liu( )
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, National Soybean Processing Industry Technology Innovation Center, Beijing Technology and Business University, Beijing 100048, China

Peer review under responsibility of Tsinghua University Press.

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Abstract

Globally, the prevalence of anxiety and depression has reached epidemic proportions. Food-derived protein hydrolysates and peptides delivered through dietary supplementation can avoid the negative risks associated with traditional pharmaceuticals while delivering superior anxiolytic and antidepressant effects. This review summarizes current research on food-derived anxiolytic and antidepressant protein hydrolysates and peptides, and subsequently analyses their physicochemical characteristics and elaborates on their mechanisms. The aim of this work is to contribute to the in-depth study and provide a theoretical foundation for the development of related products to better serve patients with anxiety and depression.

Keywords

PeptidesAntidepressantAnxiolyticProtein hydrolysatesNeurotransmitter

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Food Science and Human Wellness
Volume 13 Issue 3,
May 2024
Pages 1168-1185
DOI: 10.26599/FSHW.2022.9250097
Cite this article:
Li W, Xi Y, Wang J, et al. Food-derived protein hydrolysates and peptides: anxiolytic and antidepressant activities, characteristics, and mechanisms. Food Science and Human Wellness, 2024, 13(3): 1168-1185. https://doi.org/10.26599/FSHW.2022.9250097

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Received: 13 September 2022
Revised: 12 October 2022
Accepted: 09 November 2022
Published: 08 February 2024
© 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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