Highlights
• CQDs and zein are added to protect polyphenols
• TA acid and Fe3+ form polyphenol-metal network
• CQDs can enhance performance of nanoparticles
Open Access
Preparation and characterization of pH-responsive metal-polyphenol structure coated nanoparticles
Ailing Caoe(
), Luyun Caib,c,d()
), Luyun Caib,c,d()Abstract
In this paper, tannic acid (TA) and Fe3+ were added to form a layer of metal-polyphenol network structure on the surface of the nanoparticles which were fabricated by zein and carbon quantum dots (CQDs) encapsulating phlorotannins (PTN). pH-Responsive nanoparticles were prepared successfully (zein-PTN-CQDs-FeIII). Further, the formation of composite nanoparticles was conf irmed by a series of characterization methods. The zeta-potential and Fourier transform infrared spectroscopy data proved that electrostatic interaction and hydrogen bonding are dominant forces to form nanoparticles. The encapsulation efficiency (EE) revealed that metal-polyphenol network structure could improve the EE of PTN. Thermogravimetric analysis and differential scanning calorimetry experiment indicated the thermal stability of zein-PTN-CQDs-FeIII nanoparticles increased because of metal-polyphenol network structure. The pH-responsive nanoparticles greatly increased the release rate of active substances and achieved targeted release.
References
[1]
M. Pascoli, R. Lima, L.F. Fraceto et al., Zein nanoparticles and strategies to improve colloidal stability: a mini-review, Front. Chem. 6 (2018) 6. https://doi.org/10.3389/fchem.2018.00006.
[2]
C. Reboredo, C.J. Navarro, C.M. Oharriz, et al., Preparation and evaluation of PEG-coated zein nanoparticles for oral drug delivery purposes, Int. J. Pharm. 597 (2021) 120287. https://doi.org/10.1016/j.ijpharm.2021.120287.
[3]
C.X. Sun, C.Q. Xu, L. Mao, et al., Preparation, characterization and stability of curcumin-loaded zein-shellac composite colloidal particles, Food Chem. 228 (2017) 656-667. https://doi.org/10.1016/j.foodchem.2017.02.001.
[4]
L. Chen, R. Liu, X. He, et al., Effects of brown seaweed polyphenols, a class of phlorotannins, on metabolic disorders via regulation of fat function, Food Funct. 12 (2021) 2378-2388. https://doi.org/10.1039/d0fo02886j.
[5]
J. Cotas, A. Leandro, P. Monteiro, et al., Seaweed phenolics: from extraction to applications, Mar. Drugs 18 (2020) 384. https://doi.org/10.3390/md18080384.
[6]
J. Poole, A. Diop, L.C. Rainville, et al., Bioextracting polyphenols from the brown seaweed ascophyllum nodosum from Québec’s North Shore Coastline, Ind. Biotechnol. 15 (2019) 212-218. https://doi.org/10.1089/ind.2019.0008.
[7]
V. Ummat, B.K. Tiwari, A.K. Jaiswal, et al., Optimisation of ultrasound frequency, extraction time and solvent for the recovery of polyphenols, phlorotannins and associated antioxidant activity from brown seaweeds, Mar. Drugs 18 (2020). https://doi.org/10.3390/md18050250.
[8]
Z. Fu, R. Chen, Study of complexes of tannic acid with Fe(Ⅲ) and Fe(Ⅱ), J. Anal. Methods Chem. 2019 (2019) 3894571. https://doi.org/10.1155/2019/3894571.
[9]
Z. Guo, W. Xie, J. Lu, et al., Tannic acid-based metal phenolic networks for bio-applications: a review, J. Mater. Chem. B 9 (2021) 4098-4110. https://doi.org/10.1039/d1tb00383f.
[10]
J. Guo, T. Suma, J.J. Richardson, et al., Modular assembly of biomaterials using polyphenols as building blocks, ACS Biomater. Sci. Eng. 5 (2019) 5578-5596. https://doi.org/10.1021/acsbiomaterials.8b01507.
[11]
J. Guo, Y. L. Ping, H. Ejima, et al., Engineering multifunctional capsules through the assembly of metal-phenolic networks, Angew. Chem. Int. Ed. 53(2014) 5546-5551. https://doi.org/10.1002/ange.201311136.
[12]
H. Huang, P. Li, C. Liu, et al., pH-Responsive nanodrug encapsulated by tannic acid complex for controlled drug delivery, RSC Adv. 7 (2017) 2829-2835. https://doi.org/10.1039/c6ra26936b.
[13]
C. Maerten, L. Lopez, P. Lupattelli, et al., Electrotriggered confined self-assembly of metal-polyphenol nanocoatings using a morphogenic approach, Chem. Mater. 29 (2017) 9668-9679. https://doi.org/10.1021/acs.chemmater.7b03349.
[14]
D.D. Milincic, D.A. Popovic, S.M. Levic, et al., Application of polyphenolloaded nanoparticles in food industry, Nanomaterials 9 (2019) 1629. https://doi.org/10.3390/nano9111629.
[15]
V.J. Lingayat, N.S. Zarekar, R.S. Shendge et al., Solid lipid nanoparticles: a review, Nanosci. Nanotechnol. Res. 4 (2017) 62-67. https://doi.org/10.12691/nnr-4-2-5.
[16]
B. Bahrami, M.H. Farsangi, H. Mohammadi, et al., Nanoparticles and targeted drug delivery in cancer therapy, Immunol. Lett. 190 (2017) 64-83. https://doi.org/10.1016/j.imlet.2017.07.015.
[17]
H. Li, D.F. Wang, C.Z. Liu, et al., Fabrication of stable zein nanoparticles coated with soluble soybean polysaccharide for encapsulation of quercetin, Food Hydrocoll. 87 (2019) 342-351. https://doi.org/10.1016/j.foodhyd.2018.08.002.
[18]
H. Ejima, J.J. Richardson, K. Liang, et al., One-step assembly of coordination complexes for versatile film and particle engineering, Science 341 (2013) 154-157. https://doi.org/10.1016/j.foodhyd.2019.105381.
[19]
L. Zhang, C. Wang, R. Yang, et al., Novel environment-friendly magnetic bentonite nanomaterials functionalized by carboxymethyl chitosan and 1-(2-pyridinylazo)-2-naphthaleno for adsorption of Sc (Ⅲ), Appl. Surf. Sci.566 (2021). https://doi.org/10.1016/j.apsusc.2021.150644.
[20]
Q. Liu, Y. Jing, C. Han, et al., Encapsulation of curcumin in zein/caseinate/sodium alginate nanoparticles with improved physicochemical and controlled release properties, Food Hydrocoll. 93 (2019) 432-442. https://doi.org/10.1016/j.foodhyd.2019.02.003.
[21]
Z. Y. Zhu, Y. Luo, Y. Liu, et al., Inclusion of chrysin in β-cyclodextrin and its biological activities, J. Drug Deliv. Sci. Technol. 31 (2016) 176-186. https://doi.org/10.1016/j.jddst.2016.01.002.
[22]
P. Shinde, H. Agraval, A.K. Srivastav, et al., Physico-chemical characterization of carvacrol loaded zein nanoparticles for enhanced anticancer activity and investigation of molecular interactions between them by molecular docking, Int. J. Pharm. 588 (2020) 119795. https://doi.org/10.1016/j.ijpharm.2020.119795.
[23]
B. Muhoza, S. Xia, X. Zhang, et al., Gelatin and high methyl pectin coacervates crosslinked with tannic acid: the characterization, rheological properties, and application for peppermint oil microencapsulation, Food Hydrocoll. 97 (2019) 105174. https://doi.org/10.1016/j.foodhyd.2019.105174.
[24]
Y. Fan, Y. Liu, L. Gao, et al., Improved chemical stability and cellular antioxidant activity of resveratrol in zein nanoparticle with bovine serum albumin-caffeic acid conjugate, Food Chem. 261 (2018) 283-291. https://doi.org/10.1016/j.foodchem.2018.04.055.
[25]
F.J. Xu, Y. Ping, J. Ma, et al. Comb-shaped copolymers composed of hydroxypropyl cellulose backbones and cationic poly((2-dimethyl amino) ethyl methacrylate) side chains for gene delivery, Bioconjugate Chem. 20(2009) 1449-1458. https://doi.org/10.1021/bc900044h.
[26]
N.R. Nicomel, L. Otero-Gonzalez, K. Folens, et al., Selective and enhanced nickel adsorption from sulfate- and calcium-rich solutions using chitosan, Sep. Purif. Technol. 276 (2021). https://doi.org/10.1016/j.seppur.2021.119283.
[27]
V. Ummat, B.K. Tiwari, A.K. Jaiswal, et al., Optimisation of ultrasound frequency, extraction time and solvent for the recovery of polyphenols, phlorotannins and associated antioxidant activity from brown seaweeds, Mar. Drugs 18 (2020). https://doi.org/10.3390/md18050250.
[28]
X. Liang, K. Cao, W. Li, et al., Tannic acid-fortified zein-pectin nanoparticles: Stability, properties, antioxidant activity, and in vitro digestion, Food Res. Int. 145 (2021) 110425. https://doi.org/10.1016/j.foodres.2021.110425.
Pages 1303-1310
Cite this article:
Xia Q, Liang Y, Cao A, et al. Preparation and characterization of pH-responsive metal-polyphenol structure coated nanoparticles. Food Science and Human Wellness, 2024, 13(3): 1303-1310. https://doi.org/10.26599/FSHW.2022.9250109
Metrics & Citations
Article History
Copyright
Rights and Permissions
京公网安备11010802044758号