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Open Access

Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation

Peijun Tiana,b, Yunfei Houa,b,c, Zheng Wanga,b, Jiaona Jianga,b, Xin Qiana,b, Zhihao Qua,b, Jianxin Zhaoa,b,c,d, Gang Wanga,b,c,d( ), Wei Chena,b,c
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China
School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China
Institute of Food Biotechnology (Yangzhou), Jiangnan University, Yangzhou 225004, China

Peer review under responsibility of Tsinghua University Press.

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Highlights

• Probiotics alleviate sleep-deprivation-induced cognitive impairment.

• Probiotics could modulate the melatonin system in the striatum

• Probiotics could modulate the striatal circadian rhythms genes expression

• The mechanisms of action correlate with gut microbiome and metabolite changes

Graphical Abstract

Abstract

Gut microbiome is indispensable for maintaining normal brain function. Specifically, gut microbiota plays a causal role in sleep deprivation (SD)-induced cognitive impairment. In this study, neurobehavioral effects of the Bifidobacterium breve strain (CCFM1025) were assessed in sleep-deprived mice. CCFM1025 improved the body weight and food and water intake of the mice. It also alleviated SD-induced cognitive behavioural abnormalities (in the novel object recognition test), but did not show beneficial effects on mood- and spatial memory-related behaviours. CCFM1025 significantly altered the gut microbial composition and genome function. Key microbial metabolites that may regulate sleep function were also identified, such as isovaleric acid and γ-aminobutyric acid in the gut and purine metabolites in the serum. Those metabolites may participate in gut-brain communication by acting on the striatal melatonin system, for example to increase melatonin levels, and by regulating the expression of circadian clock genes such as those encoding the adenosine A2A receptor and period circadian regulator 1. Collectively, administration of probiotics alleviated cognitive impairment and circadian rhythm disturbance induced by SD via modulation of gut microbiome and its metabolites. These findings may help guide the treatment of insomnia or other sleep disorders via dietary strategies.

Keywords

BifidobacteriumSleepCircadian rhythmPurineGut microbiome

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Food Science and Human Wellness
Volume 13 Issue 4,
July 2024
Pages 1951-1961
DOI: 10.26599/FSHW.2022.9250162
Cite this article:
Tian P, Hou Y, Wang Z, et al. Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation. Food Science and Human Wellness, 2024, 13(4): 1951-1961. https://doi.org/10.26599/FSHW.2022.9250162

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Received: 21 July 2022
Revised: 22 November 2022
Accepted: 29 January 2023
Published: 20 May 2024
© 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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