AI Chat Paper
Discover the SciOpen Platform and Achieve Your Research Goals with Ease.
Search articles, authors, keywords, DOl and etc.
{{expandStatus?'Exit ':''}}Advanced Search
Low molecular weight polysaccharides can be isolated from Sargassum thunbergii (LMPST) and in vitro experiments were conducted to evaluate the inhibitory effects on lipids. Two natures of LMPST were attained from S. thunbergii and appraised their LMPST on palmitic acid (PA) induced lipid accretion in HepG2, and 3T3-L1 cells. LMPST treatment lessened lipid deposition and intracellular free fatty acid and triglyceride intensities in PA-treated above mentioned cells. The mechanistic study publicized that LMPST2 significantly suppressed adipogenesis and stimulated the PA-treated 3T3-L1 cells occupied in the lipolysis pathway. Furthermore, in PA-treated HepG2 cells, the free fatty acid oxidation was significantly increased by LMPST2. Given these constructive properties of LMPST2 from S. thunbergii, is a potential candidate for diminishing the intracellular lipids, and for a therapeutic agent in those conditions.
C. Case, P. Jones, K. Nelson, et al., Impact of weight loss on the metabolic syndrome, Diabetes Obes. Metab. 4(6) (2002) 407-414. https://doi.org/10.1046/j.1463-1326.2002.00236.x.
X. Li, J. Wang, H. Zhang, et al., Renoprotective effect of low-molecular-weight sulfated polysaccharide from the seaweed Laminaria japonica on glycerol-induced acute kidney injury in rats, Int. J. Biol. Macromol. 95 (2017) 132-137. https://doi.org/10.1016/j.ijbiomac.2016.11.051.
Y. Li, H. Ye, T. Wang, et al., Characterization of low molecular weight sulfate Ulva polysaccharide and its protective effect against IBD in mice, Mar. Drugs 18(10) (2020) 499. https://doi.org/10.3390/md18100499.
S. Zuo, F. Li, X. Gu, et al., Wang, Effects of low molecular weight polysaccharides from Ulva prolifera on the tolerance of Triticum aestivum to osmotic stress, Int. J. Biol. Macromol. 183 (2021) 12-22. https://doi.org/10.1016/j.ijbiomac.2021.04.121.
I.P.S. Fernando, M.K.H.M. Dias, D.M.D. Madusanka, et al., Step gradient alcohol precipitation for the purification of low molecular weight fucoidan from Sargassum siliquastrum and its UVB protective effects, Int. J. Biol. Macromol. 163 (2020) 26-35. https://doi.org/10.1016/j.ijbiomac.2021.04.121.
M. Dubois, K.A. Gilles, J.K. Hamilton, et al., Colorimetric method for determination of sugars and related substances, Anal. Chem. 28(3) (1956) 350-356. https://doi.org/10.1021/ac60111a017.
S. Chandler, J. Dodds, The effect of phosphate, nitrogen and sucrose on the production of phenolics and solasodine in callus cultures of Solanum laciniatum, Plant Cell Rep. 2(4) (1983) 205-208. https://doi.org/10.1007/BF00270105.
K. Dodgson, R. Price, A note on the determination of the ester sulphate content of sulphated polysaccharides, Biochem. J. 84(1) (1962) 106-110. https://doi.org/10.1042/bj0840106.
Y. Cui, L. Zhu, Y. Li, et al., Structure of a laminarin-type β-(1→ 3)-glucan from brown algae Sargassum henslowianum and its potential on regulating gut microbiota, Carbohydr. Polym. 255 (2021) 117389. https://doi.org/10.1016/j.carbpol.2020.117389.
S. Pattanayak, S. Chakraborty, S. Biswas, et al., Degradation of methyl parathion, a common pesticide and fluorescence quenching of rhodamine B, a carcinogen using β-D glucan stabilized gold nanoparticles, J. Saudi Chem. Soc. 22 (2018) 937-948. https://doi.org/10.1016/j.jscs.2018.02.004.
X. Chen, Z. Tian, H. Cheng, et al., Adsorption process and mechanism of heavy metal ions by different components of cells, using yeast (Pichia pastoris) and Cu2+ as biosorption models, RSC Adv. 11 (2021) 17080-17091.https://doi.org/10.1039/D0RA09744F.
S.R. Yende, U.N. Harle, B.B. Chaugule, Therapeutic potential and health benefits of Sargassum species, Pharmacogn Rev. 8 (2014) 1-7. https://doi.org/10.4103/0973-7847.125514.
A. Guilherme, J.V. Virbasius, V. Puri, et al., Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes, Nat. Rev. Mol. Cell Biol. 9 (2008) 367-377. https://doi.org/10.1038/nrm2391.
S. Farmer, Regulation of PPARγ activity during adipogenesis, Int. J. Obes. 29 (2005) S13-S16. https://doi.org/10.1038/sj.ijo.0802907.
E.D. Rosen, C.H. Hsu, X. Wang, et al., C/EBPα induces adipogenesis through PPARγ: a unified pathway, Genes Dev. 16 (2002) 22-26. https://doi.org/10.1101/gad.948702.
S.E. Mazibuko-Mbeje, K. Ziqubu, P.V. Dludla, et al., Isoorientin ameliorates lipid accumulation by regulating fat browning in palmitate-exposed 3T3-L1 adipocytes, Metabolism. Open 6 (2020) 100037. https://doi.org/10.1016/j.metop.2020.100037.
N.N. Li, X.D. Fu, M.S. Xiao, et al., Enzymatic preparation of a low- molecular-weight polysaccharide rich in uronic acid from the seaweed Laminaria japonica and evaluation of its hypolipidemic effect in mice, Food Sci. Human Wellness. 11 (2020) 2395-2405. https://doi.org/10.1039/C9FO02994J.
K. Harada, W.J. Shen, S. Patel, et al., Resistance to high-fat diet-induced obesity and altered expression of adipose-specific genes in HSL-deficient mice, Am. J. Physiol.-Endocrinol. Metab. 285 (2003) E1182-E1195. https://doi.org/10.1152/ajpendo.00259.2003.
V. Marzolla, A. Feraco, S. Gorini, et al., The novel non-steroidal MR antagonist finerenone improves metabolic parameters in high-fat diet-fed mice and activates brown adipose tissue via AMPK-ATGL pathway, FASEB J. 34 (2020) 12450-12465. https://doi.org/10.1096/fj.202000164R.
V. Lala, A. Goyal, P. Bansal, et al., Liver function tests, StarPearls (2020) 29494096.
I. Fki, S. Sayadi, A. Mahmoudi, et al., Comparative study on beneficial effects of hydroxytyrosol-and oleuropein-rich olive leaf extracts on high-fat diet-induced lipid metabolism disturbance and liver injury in rats, Biomed. Res. Int. 2020 (2020) 15. https://doi.org/10.1155/2020/1315202.
J. Kerner, C. Hoppel, Fatty acid import into mitochondria, Biochim. Biophys. Acta-Mol. Cell Biol. Lipids 1486 (2000) 1-17. https://doi.org/10.1016/S1388-1981(00)00044-5.
H.S. Lee, K.Y. Keum, S.K. Ku, Effects of Picrorrhiza rhizoma water extracts on the subacute liver damages induced by carbon tetrachloride, J. Med. Food 10 (2007) 110-117. https://doi.org/10.1089/jmf.2006.0114.
1042
Views
167
Downloads
0
Crossref
0
Web of Science
0
Scopus
0
CSCD
Altmetrics
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
京公网安备11010802044758号