Research advances on encapsulation of probiotics with nanomaterials and their repair mechanisms on intestinal barriers

Xiaochen Wang; Mengxi Yu; Jianming Ye; Ting Liu; Lijuan Jian; Xiaoyan Zheng; Yuan Wang; Wei Song; Yane Luo; Tianli Yue

doi:10.26599/FSHW.2022.9250246

| Sign up

PDF (3.4 MB)

Cite

EndNote(RIS) BibTeX

Collect

Submit Manuscript

Show Outline

Figures (4)

Fig. 1

Fig. 2

Fig. 3

Fig. 4

Tables (1)

Table 1

Open Access

Research advances on encapsulation of probiotics with nanomaterials and their repair mechanisms on intestinal barriers

Xiaochen Wang^{^a^,¹}, Mengxi Yu^{^a^,¹}, Jianming Ye^{^a^,¹}, Ting Liu^{^a}, Lijuan Jian^{^a}, Xiaoyan Zheng^{^b}, Yuan Wang^{^a^,^c^,^d}, Wei Song^{^a^,^c^,^d}, Yane Luo^{^a^,^c}(), Tianli Yue^{^a^,^c^,^d}

College of Food Science and Technology, Northwest University, Xi'an 710069, China

College of Chemical Engineering, Northwest University, Xi'an 710069, China

Laboratory of Nutritional and Healthy Food-Individuation Manufacturing Engineering, Xi'an 710069, China

Research Center of Food Safety Risk Assessment and Control, Xi'an 710069, China

¹ The authors contributed equally.

Peer review under responsibility of Tsinghua University Press.

Show Author Information

Abstract

Probiotics participate in various physiological activities and contribute to body health. However, their viability and bioefficacy are adversely affected by gastrointestinal harsh conditions, such as gastric acid, bile salts and various enzymes. Fortunately, encapsulation based on various nanomaterials shows tremendous potential to protect probiotics. In this review, we introduced some novel encapsulation technologies involving nanomaterials in view of predesigned stability and viability, selective adhesion, smart release and colonization, and efficacy exertion of encapsulated probiotics. Furthermore, the interactions between encapsulated probiotics and the gastrointestinal tract were summarized and analyzed, with highlighting the regulatory mechanisms of encapsulated probiotics on intestinal mechanical barrier, chemical barrier, biological barrier and immune barrier. This review would benefit the food and pharmaceutical industries in preparation and utilization of multifunctional encapsulated probiotics.

Keywords

Probiotics Encapsulation Environment-responsive release Repair mechanisms Selective colonization

References

[1]

K.E. Barrett, New ways of thinking about (and teaching about) intestinal epithelial function, Adv. Phy. Edu. 32 (2008) 25-34. http://doi.org/10.1152/advan.00092.2007.

Nanotechnology	Strains	Material 1	Material 2	Preparation methods	Encapsulation mechanisms	References
Metal nanoparticles	L. plantarum	Fe₃O₄	Pectin	Mechanical stirring	Electrostatic attraction	[38, 155]
Metal nanoparticles	Pediococcus pentosaceus Li05	MgO	Alginate-gelatin	Electrostatic microencapsulation unit	Hydrogen bond, electrostatic attraction, coordination compound	[156-157]
Polymer nanoparticles	L. plantarum	Cellulose fiber	Cellulose nanofiber	Mechanical stirring	Electrostatic attraction	[158]
		Pectin	Starch	Mechanical stirring	Hydrogen bond	[159-160]
		Grafting sodium polyacrylate from alginate	Alginate	Mechanical stirring	Calcium ions crosslink	[161]
	L. reuteri	Carboxymethyl konjac glucomannan	Chitosan	Mechanical stirring	Hydrogen bond electrostatic attraction	[162]
Liposome	L. rhamnosus	Alginate	Chitosan	Mechanical stirring	Electrostatic attraction	[163]
	L. rhamnosus	Alginate	-	Mechanical stirring	Calcium ions crosslink	[75]
	L. rhamnosus	Lecithin	Chitosan- fish skin	Mechanical stirring	Electrostatic attraction	[37, 164]
		Pt	mPEG-DSPE	Mechanical stirring	-	[55]
	E. coli Nissle 1917	Dioleoylphosphatydic acid	Cholesterol	Mechanical stirring	Self-assembly	[34]
Nanofiber	L. plantarum	Polylactic acid	-	Coaxial electrospinning	Hydrogen bond	[165-166]
	L. acidophilus	Gum Arabic	Polyvinyl alcohol	Electrospinning	Hydrogen bond	[61]
	L. rhamnosus, L. acidophilus, L. plantarum	Gum Arabic	Pullulan	Electrospinning	-	[167]
	Bifidobacterium animalis Bb12	Chitosan	Poly (vinyl alcohol)	Electrospinning	Hydrogen bond	[168-169]
	Lactobacilli bifidobacteria	Sodium alginate	Corn starch	Electrospinning	Hydrogen bond	[170-171]
Nano coating	L. acidophilus	Chitosan	Sulfated β-glucan	Mechanical stirring	Electrostatic attraction	[172-173]
	L. acidophilus	Oligosaccharides	Sodium alginate	Mechanical stirring	Schiff-base reaction	[174]
	E. coli Nissle 1917	Tannic acid	FeCl₃·6H₂O	Mechanical stirring	Coordination compound	[41, 175]
	E. coli Nissle 1917	Tannic acid	FeCl₃ and Eudragit L100	Co-culture	Coordination compound	[68, 176]
	L. rhamnosus	Polydopamine		Mechanical stirring	Hydrogen bonding	[40]
Biofilm encapsulation	L. plantarum	Protein BslA	Protein TasA	Co-culture	Self-assembly	[73]
	L. acidophilus, L. casei, L. rhamnosus	Alginate	-	Mechanical stirring	Calcium ions crosslink	[74]
	S. boulardii	Alginate	-	Co-culture	Calcium ions crosslink	[177]