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The impact of the novel starch-lipid complexes on the glucolipids metabolism, inflammation, and gut dysbiosis of type 2 diabetes mellitus rats

Yingshuang Lua,1, Renbing Qinb,1, Jin Wanga, Fengjuan Xiangb, Yan Zhanga, Bowei Zhanga, Dancai Fana, Huan Lüa, Xuemeng Jia, Shujun Wangc, Shuo Wanga()
Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China
School of Food Science, Henan Institute of Science and Technology, Xinxiang 453600, China
State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin 300457, China

1 These authors contributed equally to this work.

Peer review under responsibility of Tsinghua University Press.

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Abstract

It has been widely accepted that resistant starch (RS) provides numerous health benefits for human. In this research, we aimed at evaluating the performance of novel starch-lipid complexes, RS5, in comparison with RS2 on physical features, glucolipids metabolism, inflammation, and gut microbiota profiles of type 2 diabetes mellitus (T2DM) rats. The T2DM model was established by streptozotocin injection to the high-fat-sugar fed rats. According to a serial of biochemical analyses, we found that RS5 diets were strongly correlated with enhanced homeostatic model assessment for insulin secretion (HOMA-IS), high-density lipoprotein cholesterol (HDL-C), adiponectin (ADP), insulin action index (IAI), glucagon-like peptide-1 (GLP1), and short-chain fatty acids (SCFAs) in T2DM rats whilst negatively associated with the low-density lipoprotein (LDL-C) and inflammatory cytokines, showing the capabilities to ameliorate T2DM symptoms by regulation of glucolipid metabolism, gut metabolites, and inflammation. On the other hand, RS2-enriched supplementations were influential in the mediation of insulin secretion to improve glucose metabolism. The increasing evidence collected herein suggested that intestinal microbiota could mediate glucolipids metabolism and alleviate inflammation after certain microflora nourished by RS. In addition, RS intake made an impact on phosphoinositide 3-kinase/protein kinase B signaling pathway that might contribute to the improvement of glucose metabolism, insulin resistance, and inflammatory responses.

Keywords

Resistant starchType 2 diabetesGlucolipid metabolismGut microbiotaInflammation

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Food Science and Human Wellness
Volume 13 Issue 6,
November 2024
Pages 3210-3223
DOI: 10.26599/FSHW.2023.9250008
Cite this article:
Lu Y, Qin R, Wang J, et al. The impact of the novel starch-lipid complexes on the glucolipids metabolism, inflammation, and gut dysbiosis of type 2 diabetes mellitus rats. Food Science and Human Wellness, 2024, 13(6): 3210-3223. https://doi.org/10.26599/FSHW.2023.9250008
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