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Open Access

Dietary (poly)phenol intake is associated with cardiometabolic health parameters in adolescents

Emily P. Laveriano-Santosa,b,1, Sara Castro-Barquerob,c,1, Camila Arancibia-Riverosa, Ruiz-León Ana Maríab,c,d, Rosa Casasb,c, Ramón Estruchb,c, Patricia Bodegae,f, Mercedes de Miguele,f, Amaya de Cos-Gandoye,f, Jesús Martínez-Gómezf, Gloria Santos-Beneite,g, Juan M. Fernández-Alviraf, Rodrigo Fernández-Jiménezf,h,i, Rosa M. Lamuela-Raventósa,b( ), Anna Tresserra-Rimbaua,b( )
Department de Nutrició, Ciències de l’Alimentació I Gastronomia, XIA, Facultat de Farmàcia i Ciències de l’alimentació, Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), Universitat de Barcelona, Barcelona 08028, Spain
Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos Ⅲ (ISCⅢ), Madrid 28029, Spain
Department of Internal Medicine, Hospital Clínic, Institutd’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona 08036, Spain
Mediterranean Diet Foundation, Barcelona 08021, Spain
Foundation for Science, Health and Education (SHE), Barcelona 08008, Spain
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid 28029, Spain
The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York 10029, USA
CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid 28029, Spain
Hospital Universitario Clínico San Carlos, Madrid 28040, Spain

1 Equally author contribution.

Peer review under responsibility of Tsinghua University Press.

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Highlights

• The highest intake of dietary polyphenols in adolescents was associated with better cardiometabolic parameters.

• Adolescents with a daily intake of 400–600 mg flavanols or flavan-3-ols had a lower waist circumference and blood glucose levels, and higher HDL cholesterol).

• Daily phenolic acid intake of more than 124.7 mg was associated with a lower waist circumference and triglycerides in adolescents compared to the lowest intake (less than 60.9 mg/day).

• Daily stilbene intake of more than 0.30 mg was associated with lower blood glucose and triglyceride levels, and higher HDL cholesterol in adolescents compared to the lowest intake (less than 0.03 mg/day)

Abstract

The protective role of (poly)phenols against metabolic disorders has been extensively studied in adults but not in adolescents. To assess associations of dietary (poly)phenols and their subclasses with cardiometabolic health parameters in adolescents. A cross-sectional study was conducted in 944 individuals aged 11–14 years enrolled in the SI! Program for Secondary Schools trial (NCT03504059). (Poly)phenol intake was assessed using semi-quantitative food frequency questionnaires and the Phenol-Explorer database. The measured cardiometabolic parameters were waist circumference (WC) age-sex Z-score, blood pressure (BP) age-sex Z-score, blood glucose (BG), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-c). Multilevel mixed-effect linear regression models were applied to examine the association between (poly)phenol quintiles and cardiometabolic health parameters. Compared to the lowest quintile, adolescents in the highest quintile of total (poly)phenol intake had lower WC Z-scores, mean arterial pressure Z-scores, and HDL-c after multivariable adjustment. The WC Z-scores and HDL-c were lower in the highest quintile of flavonoid intake compared to the lowest quintile. The highest quintile of phenolic acid intake was associated with a lower WC Z-score and TG levels, and the highest quintile of stilbene intake with lower BG and TG, and with higher HDL-c compared to the lowest quintile. A higher intake of (poly)phenols, especially flavonoids, phenolic acids, and stilbenes, was associated with better cardiometabolic parameters in adolescents.

Keywords

PhytochemicalResveratrolLignanFlavan-3-olsAnthocyaninCardiovascular healthTeenagers

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Food Science and Human Wellness
Volume 13 Issue 6,
November 2024
Pages 3381-3390
DOI: 10.26599/FSHW.2023.9250023
Cite this article:
Laveriano-Santos EP, Castro-Barquero S, Arancibia-Riveros C, et al. Dietary (poly)phenol intake is associated with cardiometabolic health parameters in adolescents. Food Science and Human Wellness, 2024, 13(6): 3381-3390. https://doi.org/10.26599/FSHW.2023.9250023

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Received: 22 November 2022
Accepted: 27 January 2023
Published: 18 December 2024
© 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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