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Open Access

Protective effects of Bifidobacterium breve on imiquimod-induced psoriasis in mice through secondary bile acid production and FXR-TLR4/NF-κB pathway

Xinqi Chena,b, Yang Chena,b, Catherine Stantonc,d,e, R.Paul Rossc,d, Jianxin Zhaoa,b, Bo Yanga,b,c( ), Wei Chena,b,f
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
International Joint Research Center for Probiotics & Gut Health, Jiangnan University, Wuxi 214122, China
APC Microbiome Ireland, University College Cork, Cork T12 YT20, Ireland
Teagasc Food Research Centre, Cork T12 YT20, Ireland
National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China

Peer review under responsibility of Tsinghua University Press.

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Graphical Abstract

Abstract

This study aimed to evaluate the effects of Bifidobacterium breve CCFM683 on psoriasis and to investigate the underlying mechanisms. B. breve CCFM683 significantly ameliorated psoriasis in mice as well as elevated the deoxycholic acid (DCA) and lithocholic acid (LCA) in the colon compared with those of the imiquimod (IMQ)-treated mice. Meanwhile, B. breve CCFM683 increased the relative abundance of DCA-producing Lachnoclostridium and diminished the harmful Desulfovibrio and Prevotellaceae UCG001. Additionally, the farnesoid X receptor (FXR) in the skin was activated and the expression of the Toll-like receptor 4 (TLR4)/ nuclear factor kappa-B (NF-κB) pathway was inhibited, and the downstream interleukin (IL)-17 and tumor necrosis factor (TNF)-α were downregulated whereas IL-10 was up- regulated. Moreover, the subsequent hyperproliferation of keratinocytes and the dysfunction of the epidermal barrier were improved. In conclusion, CCFM683 administration ameliorated IMQ-induced psoriasis via modulating gut microbiota, promoting the DCA production, regulating the FXR -TLR4/NF-κB pathway, diminishing proinflammatory cytokines, and regulating keratinocytes and epidermal barrier. These findings may be conducive to elucidating the mechanism for probiotics to ameliorate psoriasis and to promote its clinical trials in skin disease.

Keywords

PsoriasisBifidobacterium breveGut microbiotaSecondary bile acidsFXR-TLR4/NF-κB pathway

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Food Science and Human Wellness
Volume 13 Issue 6,
November 2024
Pages 3447-3460
DOI: 10.26599/FSHW.2023.9250029
Cite this article:
Chen X, Chen Y, Stanton C, et al. Protective effects of Bifidobacterium breve on imiquimod-induced psoriasis in mice through secondary bile acid production and FXR-TLR4/NF-κB pathway. Food Science and Human Wellness, 2024, 13(6): 3447-3460. https://doi.org/10.26599/FSHW.2023.9250029

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Received: 30 December 2022
Revised: 13 March 2023
Accepted: 05 April 2023
Published: 18 December 2024
© 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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