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Open Access

Nostoc commune Vauch. polysaccharide alleviates Pb-induced hepatorenal toxicity by changing gut bacteriome, mycobiome, and metabolome

Yue Liua,1, Ping Rena,1, Hailong Lia, Yingying Liua, Yiting Yanga, Wanting Wanga, Jiaming Zhoua, Ling Suc, Lili Guana,b( ), Hongxia Maa,b( )
College of Life Sciences, Jilin Agricultural University, Changchun 130118, China
Engineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, Jilin Agricultural University, Changchun 130118, China
Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun 130118, China

Peer review under responsibility of Tsinghua University Press.

1 The authors contributed equally to this work.

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Highlights

• NCVP has an alleviative effect on Pb-induced mice with acute hepatorenal injury.

• NCVP manipulates the imbalance of gut bacteriobiota and mycobiota affected by Pb.

• NCVP regulates Pb-induced gut microbial metabolites and metabolic pathways.

Graphical Abstract

Abstract

This study aimed to explore the protective effect and potential mechanism of Nostoc commune Vauch. polysaccharide (NCVP) on lead (Pb)-poisoning mice. NCVP improved Pb-induced hepatorenal toxicity and inflammatory responses and modulated key indicators of antioxidant capacity. Moreover, the down-regulation of critical proteins of the Nrf2 pathway induced by Pb could be reversed after NCVP intervention. In addition, NCVP maintained the diversity of gut bacteriobiota and restored the relative abundance of f_Prevotellaceae, g_Alloprevotella, and f_Eubacterium_coprostanoligenes_group reduced by Pb. Also, NCVP regulated the diversity and abundance of gut mycobiota affected by Pb. Specifically, Pb decreased the proportion of pathogenic species (g_Fusarium, p_Basidiomycota, g_Alternaria, g_Aspergillus, and g_Candida) while NCVP increased the abundance of probiotics species (g_Kazachstania and p_Ascomycota). Furthermore, the metabolomic analysis found that NCVP significantly altered a range of microbial metabolites, including porphobilinogen, cromakalim, salidroside, and trichostatin A, which has significant associations with specific gut bacteriobiota or mycobiota. These altered metabolites are involved in primary bile acid biosynthesis, metabolism of xenobiotics by cytochrome P450, lysine degradation, and other metabolic pathways. Overall, our findings indicate that NCVP might be an excellent natural product for eliminating Pb-induced hepatorenal toxicity, possibly by regulating gut bacteriome, mycobiome and metabolome.

Keywords

Nostoc commune Vauch. polysaccharideLeadHepatorenal injuryGut bacteriobiotaMetabolome

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Food Science and Human Wellness
Volume 13 Issue 6,
November 2024
Pages 3482-3500
DOI: 10.26599/FSHW.2023.9250032
Cite this article:
Liu Y, Ren P, Li H, et al. Nostoc commune Vauch. polysaccharide alleviates Pb-induced hepatorenal toxicity by changing gut bacteriome, mycobiome, and metabolome. Food Science and Human Wellness, 2024, 13(6): 3482-3500. https://doi.org/10.26599/FSHW.2023.9250032

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Received: 07 January 2023
Revised: 19 February 2023
Accepted: 14 April 2023
Published: 18 December 2024
© 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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