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Research Article | Open Access | Just Accepted

A novel low molecular weight compound polysaccharides from Chinese herbal medicines: purification, characterization and anti-tumor activities in vitro and in vivo

Xu Yang1( )Dongli Cao1Haiyu Ji2Huijing Xu1Mengjie Xu1Anjun Liu2( )

1 National Center of Inspection and Testing for Processed Food Quality, Tianjin Institute for Food Safety Inspection Technology, Tianjin, 300308, China

2 Key Laboratory of Food Nutrition and Safety, Ministry of Education, School of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, 300457, China

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Abstract

A novel low molecular weight polysaccharide (LMW-CPS) was identified from a specific combination of Chinese herb ingredients. The monosaccharide composition of LMW-CPS was consisted of single arabinose, which had an α-L-furanose configuration with an average molecular weight of 2.06 kDa. NMR spectra and monosaccharide constitution analyses revealed that it had a backbone of →5)-α-L-Araf-(1→ with α-L-Araf-(1→ as the terminal residue. In vitro experiments found that it could lead to apoptosis and inhibit hepatocellular carcinoma cell proliferation by arresting them in the S phase. In vivo experiments showed that it protected immune organs such as the thymus and spleen, enhanced immune cell activities, stimulated cytokine release, augmented the abundance of CD8, CD3, CD4, and CD19 positive lymphocytes, and markedly impeded solid hepatocellular carcinoma progression in mice. H&E staining and cell cycle examination also indicated that LMW-CPS arrested hepatocellular carcinoma cells at the S phase to induce apoptosis. These findings indicated its promising potential for the treatment of hepatocellular carcinoma.

Food Science and Human Wellness
Cite this article:
Yang X, Cao D, Ji H, et al. A novel low molecular weight compound polysaccharides from Chinese herbal medicines: purification, characterization and anti-tumor activities in vitro and in vivo. Food Science and Human Wellness, 2024, https://doi.org/10.26599/FSHW.2024.9250111

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Received: 17 June 2023
Revised: 19 July 2023
Accepted: 17 October 2023
Available online: 05 June 2024

© Tsinghua University Press 2024

Reprints and Permission requests may be sought directly from editorial office.
Email: nanores@tup.tsinghua.edu.cn

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