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Article | Open Access

Natural product chlorogenic acid achieves pharmacological activity and health protection via regulating gut microbiota: a review

Ke Fua,1, Shu Daia,1, Yafang Zhanga,1, Jia Gongb, Cheng Wanga, Chenhao Yaoa, Shenglin Zhanga, Cheng Penga, Yunxia Lia()
State Key Laboratory of Southwestern Chinese Medicine Resources, Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
College of Enology, Northwest A&F University, Yangling 712100, China

1 These authors contributed equally to this work.

Peer review under responsibility of Beijing Academy of Food Sciences.

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Highlights

• Gut microbiota is a key target for chlorogenic acid (CA) to exert multiple health benefits.

• CA alters the structural composition of gut microbiota.

• CA regulates the balance between the microbiota and the intestinal immune system.

• CA increases the metabolites of gut microbiota, such as short-chain fatty acids.

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Abstract

Chlorogenic acid (CA) is a natural plant-derived polyphenol compound that is widely present in beverages (coffee and tea), fruits (blueberry, apple, and mulberry), and medicinal plants (Lonicera japonica, Eucommia ulmoides, and Cichorium intybus). In recent years, CA has attracted extensive attention due to its various health benefits, such as anti-inflammatory, immunomodulatory, anti-obesity, anti-diabetes mellitus, and neuroprotection activities. Interestingly, the low bioavailability of CA corresponds to high bioactivity, which raises a key scientific question of how low bioavailability CA can achieve high biological activity. In this review, we highlight the gut microbiota as a key target for connecting the two by summarizing a large amount of evidence. Specifically, the composition and abundance of gut microbiota, its metabolites, intestinal immunity, barrier function and so on were all changed under different pathological conditions such as inflammatory bowel disease, liver disease, kidney disease, cardiovascular disease, diabetes mellitus, obesity, etc. Conversely, these changes could be reversed by CA. In a word, CA could achieve pharmacological activity as well as health-protective effects by modulating intestinal immune and barrier function, gut microbiota composition, gut microbiota metabolites, and signaling pathways. This review provides new targets for the prevention and treatment of diseases by CA. Meanwhile, regulating the composition of the gut microbiota through natural products may be a potential strategy to achieve health protection.

Keywords

Chlorogenic acidBiological activityGut microbiotaInflammationShort-chain fatty acids

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Food Science and Human Wellness
Volume 14 Issue 7,
July 2025
Article number: 9250153
DOI: 10.26599/FSHW.2024.9250153
Cite this article:
Fu K, Dai S, Zhang Y, et al. Natural product chlorogenic acid achieves pharmacological activity and health protection via regulating gut microbiota: a review. Food Science and Human Wellness, 2025, 14(7): 9250153. https://doi.org/10.26599/FSHW.2024.9250153
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