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Research Article | Open Access | Just Accepted

Potential of A Yogurt Enriched with Synbiotics for Influenza Prevention and Treatment

Liqiong Song1,#Bin Liu2,3,#Yuangming Huang1Junying Zhao2,3Xianping Li2,3Weicang Qiao2,3Siqin He1Hanyu Ma4Yanpin Liu2,3Weicheng Nie5Lijun Chen2,3 ()Zhihing Ren1()

1 National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China

2 National Engineering Research Center of Dairy Health for Maternal and Child, Beijing Sanyuan Foods Co. Ltd., Beijing, China

3 Beijing Engineering Research Center of Dairy, Beijing Technical Innovation Center of Human Milk Research, Beijing Sanyuan Foods Co. Ltd., Beijing, China

4 Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences

5 Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing, China

# These authors have contributed equally to this work

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Abstract

Probiotics show anti-influenza activity, offering a potential variant-resistant alternative for infection prevention and control. In this study, we evaluated whether a  specially formulated yogurt enriched with synbiotics (named yogurt 1 in this study) with seven probiotics and six prebiotics, has anti-influenza effects and its underlying mechanisms using a mouse model challenged with influenza virus H1N1 PR8 strain. The mice were treated with phosphate-buffered saline (negative control), yogurt matrix, yogurt 1, and oseltamivir (positive control), respectively. yogurt 1 treatment improved the survival of infected mice (from 0% to 30%), alleviated pathological injuries in the lungs and colon, and reduced the viral load of influenza virus on days 3 and 7 post-infection. yogurt 1 also downregulated some inflammation-related signaling pathways and reduced the levels of proinflammatory cytokines or chemokines in the lungs or serum, including interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α) and keratinocyte chemoattractant (KC). The levels of short-chain fatty acids in the cecal content were increased, the diversity of the intestinal flora was partially restored, and influenza-specific IgG and interferon-secreting lymphocytes were enhanced following yogurt 1 administration. Thus, yogurt 1, as a commercial and easily accessible dairy product, demonstrated a notable anti-influenza effect in mice by inhibiting viral proliferation, suppressing excessive inflammatory responses, and promoting influenza virus-specific adaptive humoral and cellular immune responses, demonstrating its potential for influenza epidemic prevention and control.

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Food Science and Human Wellness
Cite this article:
Song L, Liu B, Huang Y, et al. Potential of A Yogurt Enriched with Synbiotics for Influenza Prevention and Treatment. Food Science and Human Wellness, 2024, https://doi.org/10.26599/FSHW.2024.9250326
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