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Research Article | Open Access | Just Accepted

Krill oil activates NRF2 to prevent diabetic endothelial injury in part through astaxanthin-induced inhibition of KEAP1

Huali Meng1,2Xiaoli Huang3Jian Zhou4Yan Zheng2Lei Du1,2Hui Li5Zhiyue Zhang5Linlin Xu6()Hao Wu1,2()

1 Department of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, 44 Wenhuaxi Rd., Jinan, Shandong 250012, China

2 Research Center of Translational Medicine, Jinan Central Hospital, Shandong University, 105 Jiefang Rd., Jinan, Shandong 250013, China

3 Department of Nutrition, Qilu Hospital, Cheeloo College of Medicine, Shandong University, 107 Wenhua Xi Rd., Jinan, Shandong 250012, China

4 Medical Center of Gastrointestinal Surgery, Weifang People’s Hospital, 151 Guangwen St., Weifang, Shandong 261041, China

5 NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Wenhuaxi Rd., Jinan, Shandong 250012, China

6 Department of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, 247 Beiyuan Rd., Jinan, Shandong 250033, China

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Abstract

Objective: Diabetes mellitus (DM) is a severe chronic disease that results in high morbidity and mortality. DM causes endothelial injury, such as endothelial inflammation, oxidative stress and dysfunction, as a basis for cardiovascular complications of DM. Therefore, blockage of DM-induced endothelial injury (DEI) is a viable strategy for the prevention of DM-caused adverse outcomes. However, few effective approaches have been developed for the intervention of DEI. Krill oil (KO) has been reported to have anti-inflammatory and anti-oxidative activities, but its effect on DEI is unknown. Hence, the aims of this study were to investigate the effect and molecular mechanism of KO on DEI.

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Food Science and Human Wellness
Cite this article:
Meng H, Huang X, Zhou J, et al. Krill oil activates NRF2 to prevent diabetic endothelial injury in part through astaxanthin-induced inhibition of KEAP1. Food Science and Human Wellness, 2024, https://doi.org/10.26599/FSHW.2024.9250386
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