Abstract
Objective: Diabetes mellitus (DM) is a severe chronic disease that results in high morbidity and mortality. DM causes endothelial injury, such as endothelial inflammation, oxidative stress and dysfunction, as a basis for cardiovascular complications of DM. Therefore, blockage of DM-induced endothelial injury (DEI) is a viable strategy for the prevention of DM-caused adverse outcomes. However, few effective approaches have been developed for the intervention of DEI. Krill oil (KO) has been reported to have anti-inflammatory and anti-oxidative activities, but its effect on DEI is unknown. Hence, the aims of this study were to investigate the effect and molecular mechanism of KO on DEI.