AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Journal of Advanced Ceramics Article
PDF (1.7 MB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Research Article | Open Access

Ultrasound-driven BaTiO3 nanorobots patching immunologic barrier to cure chronic rheumatoid arthritis

Le Jianga,b,†, Yifan Wanga,b,†, Chunlin Liua,b,†, Nan Xua,b, Wenshuo Lia,b, Lei Wangc, Yixian Wua,b, Jingyun Wanga,b, Zhijun Hea,b, Fengbo Suna,b, Lingyun Zhaoa,b, Qiong Wuc, Xiumei Wanga,b, Huihui Yuand( ), Xiaohui Wanga,b( ), Xiaodan Suna,b( )
State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China
MOE Key Lab. Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China
Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China

† Le Jiang, Yifan Wang, and Chunlin Liu contributed equally to this work.

Show Author Information

Graphical Abstract

Abstract

The disruption and reconstruction of the TREM2+ tissue resident macrophage (TRM) barrier on the surface of synovial lining play a key role in the activation and "remission" of rheumatoid arthritis (RA), which engender the prediction of this immunologic barrier as a potential driver for the achievement of "cure" in RA. However, strategies to promote the reconstruction of this barrier have not been reported, and the effect of patching this barrier remains unidentified. On the other hand, appropriate piezoelectric stimulation can reprogram macrophages, which has never been exerted on this barrier TRM yet. Herein, we design piezoelectric tetragonal BaTiO3 (BTO) ultrasound-driven nanorobots (USNRs) by the solvothermal synthesis method, which demonstrates satisfactory electro-mechanical conversion effects, paving the way to generate controllable electrical stimulation under ultrasound to reprogram the barrier TRM by minimally invasive injection into joint cavity. It is demonstrated that the immunologic barrier could be patched by this USNR effectively, thereby eliminating the hyperplasia of vessels and nerves (HVN) and synovitis. Additionally, TREM2 deficiency serum-transfected arthritis (STA) mice models are applied and proved the indispensable role of TREM2 in RA curing mediated by USNR. In all, our work is an interesting and important exploration to expand the classical tetragonal BTO nanoparticles in the treatment of autoimmune diseases, providing a new idea and direction for the biomedical application of piezoelectric ceramics.

Keywords

ultrasound-drivenBaTiO3 nanorobots (BTO NRs)immunologic barrierupstream driverrheumatoid arthritis (RA)

Electronic Supplementary Material

Download File(s)
JAC0730_ESM.pdf (1.8 MB)

References

[1]
Zhang F, Wei K, Slowikowski K, et al. Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. Nat Immunol 2019, 20: 928–942.
Google Scholar
[2]
Schett G, Tanaka Y, Isaacs JD. Why remission is not enough: Underlying disease mechanisms in RA that prevent cure. Nat Rev Rheumatol 2021, 17: 135–144.
Crossref Google Scholar
[3]
Gang FL, Zhang Q, Jiang L, et al. Thermochemotherapy meets tissue engineering for rheumatoid arthritis treatment. Adv Funct Mater 2021, 31: 2104131.
Crossref Google Scholar
[4]
McInnes IB, Schett G. Pathogenetic insights from the treatment of rheumatoid arthritis. Lancet 2017, 389: 2328–2337.
Crossref Google Scholar
[5]
Culemann S, Grüneboom A, Nicolás-Ávila JÁ, et al. Locally renewing resident synovial macrophages provide a protective barrier for the joint. Nature 2019, 572: 670–675.
Crossref Google Scholar
[6]
Alivernini S, MacDonald L, Elmesmari A, et al. Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. Nat Med 2020, 26: 1295–1306.
Crossref Google Scholar
[7]
Dai XH, Heng BC, Bai YY, et al. Restoration of electrical microenvironment enhances bone regeneration under diabetic conditions by modulating macrophage polarization. Bioact Mater 2021, 6: 2029–2038.
Crossref Google Scholar
[8]
Wang ZY, He XZ, Tang BL, et al. Polarization behavior of bone marrow-derived macrophages on charged P(VDF–TrFE) coatings. Biomater Sci 2021, 9: 874–881.
Crossref Google Scholar
[9]
Hoare JI, Rajnicek AM, McCaig CD, et al. Electric fields are novel determinants of human macrophage functions. J Leukoc Biol 2016, 99: 1141–1151.
Crossref Google Scholar
[10]
Li CM, Levin M, Kaplan DL. Bioelectric modulation of macrophage polarization. Sci Rep 2016, 6: 21044.
Crossref Google Scholar
[11]
McLean NA, Verge VMK. Dynamic impact of brief electrical nerve stimulation on the neural immune axis— Polarization of macrophages toward a pro-repair phenotype in demyelinated peripheral nerve. Glia 2016, 64: 1546–1561.
Crossref Google Scholar
[12]
Zhu P, Chen Y, Shi JL. Piezocatalytic tumor therapy by ultrasound-triggered and BaTiO3-mediated piezoelectricity. Adv Mater 2020, 32: 2001976.
Crossref Google Scholar
[13]
Zhao D, Feng PJ, Liu JH, et al. Electromagnetized-nanoparticle-modulated neural plasticity and recovery of degenerative dopaminergic neurons in the mid-brain. Adv Mater 2020, 32: 2003800.
Crossref Google Scholar
[14]
Zagórska A, Través PG, Lew ED, et al. Diversification of TAM receptor tyrosine kinase function. Nat Immunol 2014, 15: 920–928.
Crossref Google Scholar
[15]
Deczkowska A, Weiner A, Amit I. The physiology, pathology, and potential therapeutic applications of the TREM2 signaling pathway. Cell 2020, 181: 1207–1217.
Crossref Google Scholar
[16]
Katzenelenbogen Y, Sheban FD, Yalin A, et al. Coupled scRNA-seq and intracellular protein activity reveal an immunosuppressive role of TREM2 in cancer. Cell 2020, 182: 872–885.e19.
Crossref Google Scholar
[17]
Molgora M, Esaulova E, Vermi W, et al. TREM2 modulation remodels the tumor myeloid landscape enhancing anti-PD-1 immunotherapy. Cell 2020, 182: 886–900.e17.
Crossref Google Scholar
[18]
Wang YM, Cella M, Mallinson K, et al. TREM2 lipid sensing sustains the microglial response in an Alzheimer’s disease model. Cell 2015, 160: 1061–1071.
Crossref Google Scholar
[19]
Ulland TK, Song WM, Huang SCC, et al. TREM2 maintains microglial metabolic fitness in Alzheimer’s disease. Cell 2017, 170: 649–663.e13.
Crossref Google Scholar
[20]
Schlepckow K, Monroe KM, Kleinberger G, et al. Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. EMBO Mol Med 2020, 12: e11227.
Crossref Google Scholar
[21]
Ewers M, Franzmeier N, Suárez-Calvet M, et al. Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease. Sci Transl Med 2019, 11: eaav6221.
Crossref Google Scholar
[22]
Lee HW, Moon S, Choi CH, et al. Synthesis and size control of tetragonal barium titanate nanopowders by facile solvothermal method. J Am Ceram Soc 2012, 95: 2429–2434.
Crossref Google Scholar
[23]
Wu J, Xu Q, Lin EZ, et al. Insights into the role of ferroelectric polarization in piezocatalysis of nanocrystalline BaTiO3. ACS Appl Mater Interfaces 2018, 10: 17842–17849.
Crossref Google Scholar
[24]
Adireddy S, Lin CK, Cao BB, et al. Solution-based growth of monodisperse cube-like BaTiO3 colloidal nanocrystals. Chem Mater 2010, 22: 1946–1948.
Crossref Google Scholar
[25]
DiDomenico M, Wemple SH, Porto SPS, et al. Raman spectrum of single-domain BaTiO3. Phys Rev 1968, 174: 522–530.
Crossref Google Scholar
[26]
Mapp PI, Walsh DA. Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis. Nat Rev Rheumatol 2012, 8: 390–398.
Crossref Google Scholar
[27]
Delay L, Barbier J, Aissouni Y, et al. Tyrosine kinase type A—Specific signalling pathways are critical for mechanical allodynia development and bone alterations in a mouse model of rheumatoid arthritis. Pain 2022, 163: e837–e849.
Crossref Google Scholar
[28]
Udalova IA, Mantovani A, Feldmann M. Macrophage heterogeneity in the context of rheumatoid arthritis. Nat Rev Rheumatol 2016, 12: 472–485.
Crossref Google Scholar
[29]
Boutet MA, Courties G, Nerviani A, et al. Novel insights into macrophage diversity in rheumatoid arthritis synovium. Autoimmun Rev 2021, 20: 102758.
Crossref Google Scholar
[30]
Liu Y, Dzidotor G, Le TT, et al. Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits. Sci Transl Med 2022, 14: eabi7282.
Crossref Google Scholar
[31]
Croft AP, Campos J, Jansen K, et al. Distinct fibroblast subsets drive inflammation and damage in arthritis. Nature 2019, 570: 246–251.
Crossref Google Scholar
[32]
Marotte H, Miossec P. Prevention of bone mineral density loss in patients with rheumatoid arthritis treated with anti-TNFα therapy. Biologics 2008, 2: 663–669.
Crossref Google Scholar
Journal of Advanced Ceramics
Volume 12 Issue 5,
May 2023
Pages 1105-1117
DOI: 10.26599/JAC.2023.9220730
Cite this article:
Jiang L, Wang Y, Liu C, et al. Ultrasound-driven BaTiO3 nanorobots patching immunologic barrier to cure chronic rheumatoid arthritis. Journal of Advanced Ceramics, 2023, 12(5): 1105-1117. https://doi.org/10.26599/JAC.2023.9220730

2645

Views

665

Downloads

6

Crossref

3

Web of Science

4

Scopus

0

CSCD

Altmetrics
Received: 03 December 2022
Revised: 01 January 2023
Accepted: 04 February 2023
Published: 09 March 2023
© The Author(s) 2023.

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.

The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Return