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Review Article | Open Access

Review of clinical neurorestorative strategies for spinal cord injury: Exploring history and latest progresses

Hongyun Huang1,2, Hari Shanker Sharma3, Lin Chen4, Ali Otom5, Ziad M. Al Zoubi6, Hooshang Saberi7, Dafin F. Muresanu8, Xijing He9
Institute of Neurorestoratology, Third Medical Center of PLA General Hospital, Beijing, China
Hongtianji Neuroscience Academy, Lingxiu building, Beijing, China
Intensive Experimental CNS Injury and Repair, University Hospital, UppsalaUniversity, Uppsala, Sweden
Department of Neurorestoratology, Tsinghua University Yuquan Hospital, Beijing, China
Royal Specialty Center for Spine and Musculoskeletal Disorders Amman, Jordan
Jordan Ortho and Spinal Centre, Al-Saif Medical Center, Amman, Jordan
Department of Neurosurgery, Brain and Spinal cord Injury Research center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
Department of Neurosciences “Iuliu Hatieganu,” University of Medicine and Pharmacy, Cluj-Napoca, Romania
Department of Orthopaedics, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China
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Abstract

Clinical neurorestorative therapies recently made great progress for patients with spinal cord injury (SCI). This paper systemically reviews historical perspectives, recent advancements and achievements in SCI through key neurorestorative strategies. In this study, a search was performed in the PubMed, Scopus, and Scholar Google search engines using the keywords “neurorestorative strategies”, “spinal cord injury”, “cell therapy”, “neuromodulation”, and “nerve bridges”. Clinical studies published in the English language were included. It is paramount for academic community involved in this field to take the initiative of a multicenter randomized, double-blind, and placebo-control clinical study with high level of evidence-based treatments for most SCI neurorestorative strategies in patient management. It is of utmost need to establish standard therapeutic methods for patients with SCI as early as possible.

Keywords

neurorestorative strategiesspinal cord injurycell therapyneuromodulationnerve bridges

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Journal of Neurorestoratology
Volume 6 Issue 1,
December 2018
Pages 171-178
DOI: 10.26599/JNR.2018.9040013
Cite this article:
Huang H, Sharma HS, Chen L, et al. Review of clinical neurorestorative strategies for spinal cord injury: Exploring history and latest progresses. Journal of Neurorestoratology, 2018, 6(1): 171-178. https://doi.org/10.26599/JNR.2018.9040013

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Received: 01 December 2018
Accepted: 17 December 2018
Published: 30 December 2018
© The author(s) 2018

© The authors 2018. This article is published with open access at http://jnr.tsinghuajournals.com
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