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Review Article | Open Access

Progress in research into spinal cord injury repair: Tissue engineering scaffolds and cell transdifferentiation

Changke Ma§,1, Peng Zhang§,2, Yixin Shen2( )
Department of Orthopaedics, The People's Hospital of Luhe, Nanjing 211500, Jiangsu, China
Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou 215004, Jiangsu, China

§ These authors contributed equally to this work.

Show Author Information

Abstract

As with all tissues of the central nervous system, the low regeneration ability of spinal cord tissue after injury decreases the potential for repair and recovery. Initially, in spinal cord injuries (SCI), often the surgeon can only limit further damage by early surgical decompression. However, with the development of basic science, especially the development of genetic engineering, molecular biology, tissue engineering, and materials science, some promising progress has been made in promoting the repair of central nervous system injuries. For example, transplantation of neural stem cells (NSCs), olfactory ensheathing cells (OECs), and gene- mediated transdifferentiation to repair central nervous system injury. This paper summarizes the progress and prospects of SCI repair with tissue engineering scaffold and cell transdifferentiation from an extensive literatures.

Keywords

spinal cord injurystem cellsolfactory ensheathing cellshydrogeltransdifferentiation

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Journal of Neurorestoratology
Volume 7 Issue 4,
December 2019
Pages 196-206
DOI: 10.26599/JNR.2019.9040024
Cite this article:
Ma C, Zhang P, Shen Y. Progress in research into spinal cord injury repair: Tissue engineering scaffolds and cell transdifferentiation. Journal of Neurorestoratology, 2019, 7(4): 196-206. https://doi.org/10.26599/JNR.2019.9040024

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Received: 19 September 2019
Revised: 27 November 2019
Accepted: 09 December 2019
Published: 17 January 2020
© The authors 2019

This article is published with open access at http://jnr.tsinghuajournals.com
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