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Review Article | Open Access

Brain gamma rhythm and potential treatment of neurodegenerative disease

Jianhua Zhao1,2, Ailin Du3,4, Chengbiao Lu2,3,4( )
Department of Neurology, First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan, China;
Henan Joint International Research Laboratory of Neurorestoratology for Senile Dementia / Henan Key Laboratory of Neurorestoratology, Weihui 453100, Henan, China;
Henan International Joint Laboratory for Non-invasive Brain Modulation / Key Laboratory for Brain Research of Henan Province, Xinxiang Medical University, Xinxiang 453003, Henan, China;
Department of Physiology and Neurophysiology, Xinxiang Medical University, Xinxiang 453003, Henan, China
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Abstract

In this mini-review, we illustrate the brain network oscillations in different brain areas, including the medial septal diagonal band complex (MSDB) and hippocampus, especially at gamma frequency bands (γ, 30–80 Hz) and theta frequency bands (θ, 4–12 Hz), and their induction and modulation by physical stimulation, such as light and sound, and pharmacological stimulation with agents such as agonists of the kainite subunit ionotropic glutamate receptor, metabotropic glutamate receptor, metabotropic cholinergic receptor, and nicotinic cholinergic receptor. Recent findings demonstrate that boosting gamma oscillations in specific brain areas appears to be able to restore cognitive function and reduce relative pathology in neurodegenerative diseases, such as Alzheimer’s disease. Thus, exploration of strategies to enhance or restore impaired gamma oscillations may be a new and effective method to improve the conditions in these devastating diseases.

Keywords

brain network oscillationgamma oscillationcognitive functionneurodegenerative disease

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Journal of Neurorestoratology
Volume 8 Issue 1,
March 2020
Pages 26-31
DOI: 10.26599/JNR.2020.9040002
Cite this article:
Zhao J, Du A, Lu C. Brain gamma rhythm and potential treatment of neurodegenerative disease. Journal of Neurorestoratology, 2020, 8(1): 26-31. https://doi.org/10.26599/JNR.2020.9040002

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Received: 31 October 2019
Revised: 11 December 2019
Accepted: 08 January 2020
Published: 05 March 2020
© The authors 2020

This article is published with open access at http://jnr.tsinghuajournals.com
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