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Case Report | Open Access

Vagus nerve stimulation for pediatric patients with drug-resistant epilepsy caused by genetic mutations: Two cases

Xiaoya Qin1,2,§, Sufang Lin3,4,§, Yuan Yuan1,2, Jialun Wen3,4, Qian Chen5, Xingguo Lu3,4, Yang Sun4,5, Fangping Wang3, Xiaoqin Tian3, Ning Jiang3, Jianxiang Liao3,4( ), Luming Li1,2,6,7( )
Precision Medicine & Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518071, China
National Engineering Laboratory for Neuromodulation, School of Aerospace Engineering, Tsinghua University, Beijing 100084, China
Department of Neurology, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, China
Epilepsy Center, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, China
Department of Neurosurgery, Shenzhen Children's Hospital, Shenzhen 518038, Guangdong, China
IDG/McGovern Institute for Brain Research at Tsinghua University, Beijing 100084, China
Institute of Epilepsy, Beijing Institute for Brain Disorders, Beijing 100093, China

§ These authors contributed equally to this work.

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Abstract

Vagus nerve stimulation (VNS) is a neuromodulation therapy increasingly used for treating drug-resistant epilepsy. However, it remains to be determined which patients are best suited for the treatment, and it is difficult to predict the therapeutic effect before the implantation. Mutations in some genes could lead to epilepsy. Here we report two cases of pediatric patients with drug-resistant epilepsy treated by VNS therapy: Patient 1 with ARX mutation achieved good outcomes; Patient 2 with the CDKL5 mutation did not show improvement. Additionally, the therapeutic impact of VNS on brain networks was investigated, hoping to provide some empirical evidence for a better understanding of the mechanism of VNS treatment.

Keywords

vagus nerve stimulationdrug-resistant epilepsygenetic mutationEEG brain network

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Journal of Neurorestoratology
Volume 8 Issue 3,
September 2020
Pages 138-148
DOI: 10.26599/JNR.2020.9040014
Cite this article:
Qin X, Lin S, Yuan Y, et al. Vagus nerve stimulation for pediatric patients with drug-resistant epilepsy caused by genetic mutations: Two cases. Journal of Neurorestoratology, 2020, 8(3): 138-148. https://doi.org/10.26599/JNR.2020.9040014

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Received: 15 May 2020
Revised: 05 July 2020
Accepted: 23 July 2020
Published: 19 October 2020
© The authors 2020

This article is published with open access at http://jnr.tsinghuajournals.com
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