Graphical Abstract
![](https://wqketang.oss-cn-beijing.aliyuncs.com/zip-unzip/zip-b72a8e54-0074-4a5e-8e57-caa590572e26/NBE-2023-0010/files/NBE-2023-0010-TOC.jpg?Expires=1725757087&OSSAccessKeyId=STS.NT5eViCkqzTYdbfdqxMkjpyyq&Signature=ee4ppGCVVcZnq3PfV4S%2Bq7ZZfbs%3D&security-token=CAISywJ1q6Ft5B2yfSjIr5eALuzdrrRQzZayZkTXgHEtQeRGn7zSkzz2IHtKenhsBOsbtfk1mG5W5%2FgZlqJ9SptIAEfJa9d99MzUP%2FpFltCT1fau5Jko1beHewHKeTOZsebWZ%2BLmNqC%2FHt6md1HDkAJq3LL%2Bbk%2FMdle5MJqP%2B%2FUFB5ZtKWveVzddA8pMLQZPsdITMWCrVcygKRn3mGHdfiEK00he8TouufTinpHMskGA1Aell7Mvyt6vcsT%2BXa5FJ4xiVtq55utye5fa3TRYgxowr%2Fwo0v0YpGya5YzHXwcPskvdKZbo78UqLQlla6w%2BGqFJqvPxr%2Fp8t%2Fx5fWJKAezhVgs8cVM8JOjIqKOscIsiJsO71SmqFV55c8Fdm%2BgUooJVgIMhTnduUfAPJAGOxzJitP%2BUVGGphr60TEnBL4rB5MUctfzRp75SXVPUTzDnGoABjuNLcf76FQN6p3t%2BSlCg%2FxR5C72RIk78k%2BUi44L9ZBmFT6F8GV7aXA52D1Ps56knKF6PAnhRivwyTxgsolycBfvccb3t5jGJ24SgY0aYosAECutxAo7sJhSwlwZvGwGDZJsop1vGiZ8eN1MbtZeRRuMeaZ2I%2BQo%2BnVP6Cf%2F0pDsgAA%3D%3D)
Discover the SciOpen Platform and Achieve Your Research Goals with Ease.
Surface functionalization of iron oxide nanoparticles (Fe2O3 NPs) with antibiotics is a novel approach that opens the door to drug delivery applications. In the present work, we report iron oxide nanoparticles synthesized by chemical co-precipitation method. As-synthesized nanoparticles were characterized using field emission scanning electron microscopy (FESEM) , energy dispersive X-ray (EDX), X-ray diffraction (XRD), ultraviolet (UV)–visible (Vis) spectroscopy, Fourier transform infrared (FTIR), and vibrating sample magnetometer (VSM). The poly-shaped Fe2O3 NPs of size (34 ± 10) nm with hematite (α-Fe2O3) phase were synthesized. The antibacterial activity of chloramphenicol and gentamicin and their formulation with encapsulated iron oxide nanoparticles was investigated by the agar well diffusion technique. Drug-encapsulated Fe2O3 NPs showed antibacterial activity against Escherichia coli and Staphylococcus aureus strains, possibly in a dose-dependent manner. Significant effectiveness was confirmed by the increase in the single range of inhibition against the tested microorganisms. Furthermore, the effect of iron oxide nanoparticle concentrations ranging from 1 to 9 μg/μL on bacterial growth was examined.
M. Ramezani Farani, M. Azarian, H. Heydari Sheikh Hossein, et al. Folic acid-adorned curcumin-loaded iron oxide nanoparticles for cervical cancer. ACS Applied Bio Materials, 2022, 5(3): 1305−1318. https://doi.org/10.1021/acsabm.1c01311
R.L. Siegel, K.D. Miller, H.E. Fuchs, et al. Cancer statistics, 2022. CA:a Cancer Journal for Clinicians, 2022, 72(1): 7−33. https://doi.org/10.3322/caac.21708
M. Ebadi, K. Buskaran, S. Bullo, et al. Drug delivery system based on magnetic iron oxide nanoparticles coated with (polyvinyl alcohol-zinc/aluminium-layered double hydroxide-sorafenib). Alexandria Engineering Journal, 2021, 60(1): 733−747. https://doi.org/10.1016/j.aej.2020.09.061
L.M. Ngema, S.A. Adeyemi, T. Marimuthu, et al. Synthesis of novel conjugated linoleic acid (CLA)-coated superparamagnetic iron oxide nanoparticles (SPIONs) for the delivery of paclitaxel with enhanced in vitro anti-proliferative activity on A549 lung cancer cells. Pharmaceutics, 2022, 14(4): 829. https://doi.org/10.3390/pharmaceutics14040829
T. Vangijzegem, D. Stanicki, S. Laurent. Magnetic iron oxide nanoparticles for drug delivery: Applications and characteristics. Expert Opinion on Drug Delivery, 2019, 16(1): 69−78. https://doi.org/10.1080/17425247.2019.1554647
M. Sharaf, A.H. Sewid, H.I. Hamouda, et al. Rhamnolipid-coated iron oxide nanoparticles as a novel multitarget candidate against major foodborne E. coli serotypes and methicillin-resistant S. aureus. Microbiol Spectr, 2022, 10(4): e0025022. https://doi.org/10.1128/spectrum.00250-22
S.A. Sankaranarayanan, A. Thomas, N. Revi, et al. Iron oxide nanoparticles for theranostic applications - Recent advances. Journal of Drug Delivery Science and Technology, 2022, 70: 103196. https://doi.org/10.1016/j.jddst.2022.103196
A. Mengesha, A. Hoerres, P. Mahajan. Cytocompatibility of oleic acid modified iron oxide nanoparticles. Materials Letters, 2022, 323: 132528. https://doi.org/10.1016/j.matlet.2022.132528
P. Sangaiya, R. Jayaprakash. A review on iron oxide nanoparticles and their biomedical applications. Journal of Superconductivity and Novel Magnetism, 2018, 31(11): 3397−3413. https://doi.org/10.1007/s10948-018-4841-2
S. Belaïd, D. Stanicki, L. Vander Elst, et al. Influence of experimental parameters on iron oxide nanoparticle properties synthesized by thermal decomposition: Size and nuclear magnetic resonance studies. Nanotechnology, 2018, 29(16): 165603. https://doi.org/10.1088/1361-6528/aaae59
M. Khatami, H.Q. Alijani, B.A. Fakheri, et al. Super-paramagnetic iron oxide nanoparticles (SPIONs): Greener synthesis using Stevia plant and evaluation of its antioxidant properties. Journal of Cleaner Production, 2019, 208: 1171−1177. https://doi.org/10.1016/j.jclepro.2018.10.182
S.M. Dadfar, K. Roemhild, N.I. Drude, et al. Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications. Advanced Drug Delivery Reviews, 2019, 138: 302−325. https://doi.org/10.1016/j.addr.2019.01.005
P. Bender, J. Fock, M.F. Hansen, et al. Influence of clustering on the magnetic properties and hyperthermia performance of iron oxide nanoparticles. Nanotechnology, 2018, 29(42): 425705. https://doi.org/10.1088/1361-6528/aad67d
A. Elsaidy, J.P. Vallejo, V. Salgueiriño, et al. Tuning the thermal properties of aqueous nanofluids by taking advantage of size-customized clusters of iron oxide nanoparticles. Journal of Molecular Liquids, 2021, 344: 117727. https://doi.org/10.1016/j.molliq.2021.117727
S. Parveen, A.H. Wani, M.A. Shah, et al. Preparation, characterization and antifungal activity of iron oxide nanoparticles. Microbial Pathogenesis, 2018, 115: 287−292. https://doi.org/10.1016/j.micpath.2017.12.068
A.V. Nikam, B.L.V. Prasad, A.A. Kulkarni. Wet chemical synthesis of metal oxide nanoparticles: A review. CrystEngComm, 2018, 20(35): 5091−5107. https://doi.org/10.1039/C8CE00487K
M. Singh, S. Manikandan, M. Yadav, et al. Bio-functionalized gold nanoparticles: A potent probe for profound antibacterial efficiency through drug delivery system. Asian Journal of Biological and Life Sciences, 2020, 9(2): 139−144. https://doi.org/10.5530/ajbls.2020.9.21
S.S. Alias, A.B. Ismail, A.A. Mohamad. Effect of pH on ZnO nanoparticle properties synthesized by Sol–gel centrifugation. Journal of Alloys and Compounds, 2010, 499(2): 231−237. https://doi.org/10.1016/j.jallcom.2010.03.174
A.M. Mazrouaa, M.G. Mohamed, M. Fekry. Physical and magnetic properties of iron oxide nanoparticles with a different molar ratio of ferrous and ferric. Egyptian Journal of Petroleum, 2019, 28(2): 165−171. https://doi.org/10.1016/j.ejpe.2019.02.002
H.T. Cui, Y. Liu, W.Z. Ren. Structure switch between α-Fe2O3, γ-Fe2O3 and Fe3O4 during the large scale and low temperature Sol-gel synthesis of nearly monodispersed iron oxide nanoparticles. Advanced Powder Technology, 2013, 24(1): 93−97. https://doi.org/10.1016/j.apt.2012.03.001
J.P. Mathew, G. Varghese, J. Mathew. Effect of post-thermal annealing on the structural and optical properties of ZnO thin films prepared from a polymer precursor. Chinese Physics B, 2012, 21(7): 078104. https://doi.org/10.1088/1674-1056/21/7/078104
N. Shabani, A. Javadi, H. Jafarizadeh-Malmiri, et al. Potential application of iron oxide nanoparticles synthesized by Co-precipitation technology as a coagulant for water treatment in settling tanks. Mining,Metallurgy &Exploration, 2021, 38(1): 269−276. https://doi.org/10.1007/s42461-020-00338-y
J. Chatterjee, Y. Haik, C.J. Chen. Size dependent magnetic properties of iron oxide nanoparticles. Journal of Magnetism and Magnetic Materials, 2003, 257(1): 113−118. https://doi.org/10.1016/S0304-8853(02)01066-1
T.V. Harris, R.K. Szilagyi. Iron–sulfur bond covalency from electronic structure calculations for classical iron–sulfur clusters. Journal of Computational Chemistry, 2014, 35(7): 540−552. https://doi.org/10.1002/jcc.23518
P. Bhattacharya, S. Neogi. Gentamicin coated iron oxide nanoparticles as novel antibacterial agents. Materials Research Express, 2017, 4(9): 095005. https://doi.org/10.1088/2053-1591/aa8652
R. Safarkar, R.G. Ebrahimzadeh, S. Khalili-Arjagi. The study of antibacterial properties of iron oxide nanoparticles synthesized using the extract of lichen Ramalina sinensis. Asian Journal of Nanoscience and Materials, 2020, 3(3): 157−166. https://doi.org/10.26655/AJNANOMAT.2020.3.1
M.A. Kohanski, D.J. Dwyer, B. Hayete, et al. A common mechanism of cellular death induced by bactericidal antibiotics. Cell, 2007, 130(5): 797−810. https://doi.org/10.1016/j.cell.2007.06.049
H. Sies. Oxidative stress: Oxidants and antioxidants. Experimental Physiology, 1997, 82(2): 291−295. https://doi.org/10.1113/expphysiol.1997.sp004024
L.L. Zhang, Y.H. Jiang, Y.L. Ding, et al. Investigation into the antibacterial behaviour of suspensions of ZnO nanoparticles (ZnO nanofluids). Journal of Nanoparticle Research, 2007, 9(3): 479−489. https://doi.org/10.1007/s11051-006-9150-1
J.S. Kim, E. Kuk, K.N. Yu, et al. Antimicrobial effects of silver nanoparticles. Nanomedicine:Nanotechnology,Biology and Medicine, 2007, 3(1): 95−101. https://doi.org/10.1016/j.nano.2006.12.001
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY) (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.