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Nano Biomedicine and Engineering 2024, 16(1): 1-27 https://doi.org/10.26599/NBE.2023.9290047
Review | Open Access | Issue | Published: 08 December 2023

Recent Advances in the Bioactive Structure and Application of Single-atom Nanozymes

Show Author's Information Shaofang Zhang,  Xiao-Dong Zhang( )
Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China
Keywords:
catalytic activity, applications, single-atom nanozymes, active center
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Zhang S, Zhang X-D. Recent Advances in the Bioactive Structure and Application of Single-atom Nanozymes. Nano Biomedicine and Engineering, 2024, 16(1): 1-27. https://doi.org/10.26599/NBE.2023.9290047
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Abstract Full text About this article

Single-atom nanozymes have attracted much attention as a new type of high-performance nanozymes. Compared with other nanozymes, single-atom nanozymes have become the most promising candidates for naturally-occurring enzymes due to their lower cost, better activity, more flexible preparation, higher atom utilization, and flexible compositional and structural modifications. Moreover, the catalytic activity of single-atom nanozymes can be precisely constructed by regulating the active center and synergistic environment. Advanced characterization techniques combined with theoretical calculations can accurately identify the enzyme-like active sites and deeply reveal structure-performance correlation. In this review, the active center and enzyme-like activities of single-atom nanozymes are comprehensively summarized along with the recent research advances in antitumor, neurological disorders, wound healing, and antimicrobial. Finally, we also explore the future opportunities and challenges for single-atom nanozymes in the design and applications.


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About this article

Recent Advances in the Bioactive Structure and Application of Single-atom Nanozymes

Show Author's information Shaofang Zhang, Xiao-Dong Zhang( )
Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China

Abstract

Single-atom nanozymes have attracted much attention as a new type of high-performance nanozymes. Compared with other nanozymes, single-atom nanozymes have become the most promising candidates for naturally-occurring enzymes due to their lower cost, better activity, more flexible preparation, higher atom utilization, and flexible compositional and structural modifications. Moreover, the catalytic activity of single-atom nanozymes can be precisely constructed by regulating the active center and synergistic environment. Advanced characterization techniques combined with theoretical calculations can accurately identify the enzyme-like active sites and deeply reveal structure-performance correlation. In this review, the active center and enzyme-like activities of single-atom nanozymes are comprehensively summarized along with the recent research advances in antitumor, neurological disorders, wound healing, and antimicrobial. Finally, we also explore the future opportunities and challenges for single-atom nanozymes in the design and applications.

Keywords: catalytic activity, applications, single-atom nanozymes, active center

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Publication history
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Publication history

Received: 08 September 2023
Revised: 25 September 2023
Accepted: 24 October 2023
Published: 08 December 2023
Issue date: March 2024

Copyright

© The Author(s) 2024.

Acknowledgements

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant Nos. 91859101, 81971744, U1932107, 82001952, 11804248, 82302361 and 82302381), The National Key Research and Development Program of China (2021YFF1200700), Outstanding Youth Funds of Tianjin, National Natural Science Foundation of Tianjin (19JCZDJC34000 and 20JCYBJC00940), the Innovation Foundation of Tianjin University (2023XJC-0010), China Postdoctoral Science Foundation (2023M732601), and CAS Interdisciplinary Innovation Team (JCTD-2020-08).

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