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Review | Open Access

Recent Advances in the Bioactive Structure and Application of Single-atom Nanozymes

Shaofang Zhang, Xiao-Dong Zhang( )
Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China
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Abstract

Single-atom nanozymes have attracted much attention as a new type of high-performance nanozymes. Compared with other nanozymes, single-atom nanozymes have become the most promising candidates for naturally-occurring enzymes due to their lower cost, better activity, more flexible preparation, higher atom utilization, and flexible compositional and structural modifications. Moreover, the catalytic activity of single-atom nanozymes can be precisely constructed by regulating the active center and synergistic environment. Advanced characterization techniques combined with theoretical calculations can accurately identify the enzyme-like active sites and deeply reveal structure-performance correlation. In this review, the active center and enzyme-like activities of single-atom nanozymes are comprehensively summarized along with the recent research advances in antitumor, neurological disorders, wound healing, and antimicrobial. Finally, we also explore the future opportunities and challenges for single-atom nanozymes in the design and applications.

Keywords

single-atom nanozymescatalytic activityactive centerapplications

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Nano Biomedicine and Engineering
Volume 16 Issue 1,
March 2024
Pages 1-27
DOI: 10.26599/NBE.2023.9290047
Cite this article:
Zhang S, Zhang X-D. Recent Advances in the Bioactive Structure and Application of Single-atom Nanozymes. Nano Biomedicine and Engineering, 2024, 16(1): 1-27. https://doi.org/10.26599/NBE.2023.9290047

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Received: 08 September 2023
Revised: 25 September 2023
Accepted: 24 October 2023
Published: 08 December 2023
© The Author(s) 2024.

This is an open-access article distributed under  the  terms  of  the  Creative  Commons  Attribution  4.0 International  License (CC BY) (http://creativecommons.org/licenses/by/4.0/), which  permits  unrestricted  use,  distribution,  and reproduction in any medium, provided the original author and source are credited.
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