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Review | Open Access

Radiolabeled Tracing Techniques Illuminating Blood Pharmacokinetics in Nanomedicine

Wenyao Zhou1,2, Jun Zhang1,3, Xinyu Wang1,2( ), Min Yang1,2( )
School of Pharmacy, Nanjing Medical University, Nanjing 211166, China
NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
Department of Nuclear Medicine, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou 225300, China
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Abstract

In the realm of pharmaceutical advancement, the transformative prowess of nanotechnology shines through its precision-targeted drug delivery and amplified therapeutic effects. This paper ventures into the realm of radiolabeling techniques for unraveling the intricate choreography of drug kinetics within the bloodstream which encompass the delicate stages of absorption, distribution, metabolism, and excretion. Through the magical lens of the radiolabel, a real-time spectacle unfolds, providing invaluable insights into the safety and efficacy of nanomedicine interventions. Amid the labyrinthine complexities of drug-organism interactions and the lack of universal protocols for nanomedicine preparation, radiolabeling technology has emerged as a guiding constellation. The paper systematically assesses the methods commonly employed for pharmacokinetic studies, delves into the manifold advantages and techniques of radiolabel methods within the nanomedicine landscape, closely examines their application across a spectrum of pharmacokinetic studies and thoughtfully addresses the challenges they may pose. Embark on this illuminating odyssey—a journey that peers into the microcosm of nanomedicine, deciphering its dynamic interplay within the bloodstream through the luminary insights of radiolabeled tracing techniques.

Keywords

bioimagingnanotechnologypharmacokineticsnanomedicinesradiolabel

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Nano Biomedicine and Engineering
Volume 16 Issue 1,
March 2024
Pages 48-63
DOI: 10.26599/NBE.2024.9290048
Cite this article:
Zhou W, Zhang J, Wang X, et al. Radiolabeled Tracing Techniques Illuminating Blood Pharmacokinetics in Nanomedicine. Nano Biomedicine and Engineering, 2024, 16(1): 48-63. https://doi.org/10.26599/NBE.2024.9290048

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Received: 21 September 2023
Revised: 17 October 2023
Accepted: 31 October 2023
Published: 18 December 2023
© The Author(s) 2024.

This is an open-access article distributed under  the  terms  of  the  Creative  Commons  Attribution  4.0 International  License (CC BY) (http://creativecommons.org/licenses/by/4.0/), which  permits  unrestricted  use,  distribution,  and reproduction in any medium, provided the original author and source are credited.
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