AI Chat Paper
Discover the SciOpen Platform and Achieve Your Research Goals with Ease.
Search articles, authors, keywords, DOl and etc.
{{expandStatus?'Exit ':''}}Advanced Search
Quercetin is a biologically active and widely used dietary flavonoid with robust antioxidant and chelating effects. However, due to its lesser solubility, it has poor bioavailability, which results in limited medicinal effects. This study synthesized quercetin–metal complexes, which enhanced the medicinal properties and bioavailability of quercetin. Quercetin–copper (Cu) complexes were fabricated by using copper sulfate and copper chloride in the Quercetin/Cu ratios of 1:2 and 1:1, respectively. Furthermore, Cu complexes with quercetin extracted from onion peels or standard quercetin were obtained. The current research also sought to assess the bioavailability as well as antibacterial and antioxidant properties. Spectrophotometry revealed that better complexes were prepared with a ratio of 1:2 as compared to 1:1. Copper chloride and copper sulfate showed no significant (p < 0.05) effects on complex formation. These metal complexes had a considerable impact on Bacillus subtilis (Gram+) as compared to Escherichia coli (Gram–). The pharmacokinetic parameters indicated that the oral bioavailability of quercetin–Cu(II) complexes was significantly enhanced as compared to pure quercetin. The results of this study suggested the successful formation of quercetin–metal complexes, which markedly increased the bio-availability of quercetin.
P. Karak. Biological activities of flavonoids: an overview. International Journal of Pharmaceutical Sciences and Research, 2019, 10(4): 1567−1574. https://doi.org/10.13040/IJPSR.0975-8232.10(4).1567-74
A.K. Anal. Quality ingredients and safety concerns for traditional fermented foods and beverages from Asia: A review. Fermentation, 2019, 5(1): 8. https://doi.org/10.3390/fermentation5010008
M. Symonowicz, M. Kolanek. Flavonoids and their properties to form chelate complexes. Biotechnology and Food Sciences, 2012, 76(1): 35−41.
S. Mondal, T.R. Syed. Flavonoids: A vital resource in healthcare and medicine. Pharmacy &Pharmacology International Journal, 2020, 8(2): 91−104. https://doi.org/10.15406/ppij.2020.08.00285
N. Bordenave, B.R. Hamaker, M.G. Ferruzzi. Nature and consequences of non-covalent interactions between flavonoids and macronutrients in foods. Food &Function, 2014, 5(1): 18−34. https://doi.org/10.1039/C3FO60263J
B.H. Havsteen. The biochemistry and medical significance of the flavonoids. Pharmacology &Therapeutics, 2002, 96(2-3): 67−202. https://doi.org/10.1016/s0163-7258(02)00298-x
D.O. Kim, C.Y. Lee. Comprehensive study on vitamin C equivalent antioxidant capacity (VCEAC) of various polyphenolics in scavenging a free radical and its structural relationship. Critical Reviews in Food Science and Nutrition, 2004, 44(4): 253−273. https://doi.org/10.1080/10408690490464960
G.W. Canonica, M. Blaiss. Antihistaminic, anti-inflammatory, and antiallergic properties of the nonsedating second-generation antihistamine desloratadine: A review of the evidence. World Allergy Organization Journal, 2011, 4(2): 47−53. https://doi.org/10.1097/WOX.0b013e3182093e1
N.P. Seeram, M.G. Nair. Inhibition of lipid peroxidation and structure-activity-related studies of the dietary constituents anthocyanins, anthocyanidins, and catechins. Journal of Agricultural and Food Chemistry, 2002, 50(19): 5308−5312. https://doi.org/10.1021/jf025671q
R.V. Patel, B.M. Mistry, S.K. Shinde, et al. Therapeutic potential of quercetin as a cardiovascular agent. European Journal of Medicinal Chemistry, 2018, 155: 889−904. https://doi.org/10.1016/j.ejmech.2018.06.053
G. El-Saber Batiha, A.M. Beshbishy, M. Ikram, et al. The pharmacological activity, biochemical properties, and pharmacokinetics of the major natural polyphenolic flavonoid: quercetin. Foods, 2020, 9(3): 374. https://doi.org/10.3390/foods9030374
J.S. Mu, X. Zhao, J. Li, et al. Novel hierarchical NiO nanoflowers exhibiting intrinsic superoxide dismutase-like activity. Journal of Materials Chemistry B, 2016, 4(31): 5217−5221. https://doi.org/10.1039/C6TB01390B
H. Wake, Y. Takahashi, Y. Yoshii, et al. Histidine-rich glycoprotein possesses antioxidant activity through self-oxidation and inhibition of hydroxyl radical production via chelating divalent metal ions in Fenton’s reaction. Free Radical Research, 2020, 54(8-9): 649−661. https://doi.org/10.1080/10715762.2020.1825703
H.G. Ulusoy, N. Sanlier. A minireview of quercetin: From its metabolism to possible mechanisms of its biological activities. Critical Reviews in Food Science and Nutrition, 2020, 60(19): 3290−3303. https://doi.org/10.1080/10408398.2019.1683810
L.W. Zhang, Z.B. Shang, K.X. Guo, et al. Speciation analysis and speciation transformation of heavy metal ions in passivation process with thiol-functionalized nano-silica. Chemical Engineering Journal, 2019, 369: 979−987. https://doi.org/10.1016/j.cej.2019.03.077
M. Hofmann, G. Retamal-Morales, D. Tischler. Metal binding ability of microbial natural metal chelators and potential applications. Natural Product Reports, 2020, 37(9): 1262−1283. https://doi.org/10.1039/C9NP00058E
M. Zhang, S.W. Cui, P.C.K. Cheung, et al. Antitumor polysaccharides from mushrooms: A review on their isolation process, structural characteristics and antitumor activity. Trends in Food Science and Technology, 2007, 18(1): 4−19. https://doi.org/10.1016/j.jpgs.2006.07.013
A. Czerwonka, U. Maciołek, J. Kałafut, et al. Anticancer effects of sodium and potassium quercetin-5'-sulfonates through inhibition of proliferation, induction of apoptosis, and cell cycle arrest in the HT-29 human adenocarcinoma cell line. Bioorganic Chemistry, 2020, 94: 103426. https://doi.org/10.1016/j.bioorg.2019.103426
P. Sharma, T. Joshi, T. Joshi, et al. In silico screening of potential antidiabetic phytochemicals from Phyllanthus emblica against therapeutic targets of type 2 diabetes. Journal of Ethnopharmacology, 2020, 248: 112268. https://doi.org/10.1016/j.jep.2019.112268
S. Nangare, S. Patil, K. Chaudhari, et al. Graphene quantum dots incorporated UiO-66-NH2 based fluorescent nanocomposite for highly sensitive detection of quercetin. Nano Biomedicine and Engineering, 2023, 15(1): 1−13. https://doi.org/10.26599/NBE.2023.9290005
F. Damiano, L. Giannotti, G.V. Gnoni, et al. Quercetin inhibition of SREBPs and ChREBP expression results in reduced cholesterol and fatty acid synthesis in C6 glioma cells. The International Journal of Biochemistry &Cell Biology, 2019, 117: 105618. https://doi.org/10.1016/j.biocel.2019.105618
J.N. Okolle. Research notes on current issues in cameroon agriculture. Forum for Agricultural Research in Africa, 2019, 4(14): 169.
T.N. Ravishankar, K. Manjunatha, T. Ramakrishnappa, et al. Comparison of the photocatalytic degradation of trypan blue by undoped and silver-doped zinc oxide nanoparticles. Materials Science in Semiconductor Processing, 2014, 26: 7−17. https://doi.org/10.1016/j.mssp.2014.03.027
M. Nawaz, G. Camussi, H. Valadi, et al. The emerging role of extracellular vesicles as biomarkers for urogenital cancers. Nature Reviews Urology, 2014, 11(12): 688−701. https://doi.org/10.1038/nrurol.2014.301
L. Forte, P. Torricelli, E. Boanini, et al. Quercetin and alendronate multi-functionalized materials as tools to hinder oxidative stress damage. Journal of Biomedical Materials Research Part A, 2017, 105(12): 3293−3303. https://doi.org/10.1002/jbm.a.36192
A. Pękal, M. Biesaga, K. Pyrzynska. Interaction of quercetin with copper ions: Complexation, oxidation and reactivity towards radicals. BioMetals, 2011, 24(1): 41−49. https://doi.org/10.1007/s10534-010-9372-7
S.B. Bukhari, S. Memon, M. Mahroof-Tahir, et al. Synthesis, characterization and antioxidant activity copper–quercetin complex. Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy, 2009, 71(5): 1901−1906. https://doi.org/10.1016/j.saa.2008.07.030
H.F. Talab, I.A. Zabani, H.S. Abdelrahman, et al. Intraoperative ventilatory strategies for prevention of pulmonary atelectasis in obese patients undergoing laparoscopic bariatric surgery. Anesthesia and Analgesia, 2009, 109(5): 1511−1516. https://doi.org/10.1213/ANE.0b013e3181ba7945
H. Lewandowska, M. Kalinowska, W. Lewandowski, et al. The role of natural polyphenols in cell signaling and cytoprotection against cancer development. The Journal of Nutritional Biochemistry, 2016, 32: 1−19. https://doi.org/10.1016/j.jnutbio.2015.11.006
B.H. Chang, S.H. Lee, A. Lyengar, et al. Chemical grafting of new poly (aminophenyl bornoic acid) chains onto the surface of silica nanoparticles. Advanced Materials Research, 2013, 717: 90−94. https://doi.org/10.4028/www.scientific.net/AMR.717.90
S.R. Palle, J. Penchalaneni, K. Lavudi, et al. Green synthesis of silver nanoparticles by leaf extracts of boerhavia erecta and spectral characterization and their antimicrobial, antioxidant ad cytotoxic studies on ovarian cancer cell lines. Letters in Applied NanoScience, 2020, 9(3): 1165−1176. https://doi.org/10.33263/LIANBS93.11651176
F. Vansyngel, F. Boulanger, T. Ghosh, et al. Statistical simulations of the dust foreground to cosmic microwave background polarization. Astronomy &Astrophysics, 2017, 603: A62. https://doi.org/10.1051/0004-6361/201629992
H. Bellia, R. Youcef, M. Fatima. A detailed modeling of photovoltaic module using MATLAB. NRIAG Journal of Astronomy and Geophysics, 2014, 3(1): 53−61. https://doi.org/10.1016/j.nrjag.2014.04.001
L. Barros, M.J. Ferreira, B. Queirós, et al. Total phenols, ascorbic acid, β-carotene and lycopene in Portuguese wild edible mushrooms and their antioxidant activities. Food Chemistry, 2007, 103(2): 413−419. https://doi.org/10.1016/j.foodchem.2006.07.038
R. Ronen, M. Galun,. Pigment extraction from lichens with dimethyl sulfoxide (DMSO) and estimation of chlorophyll degradation. Environmental and Experimental Botany, 1984, 24(3): 239−245. https://doi.org/10.1016/0098-8472(84)90004-2
G. Deepa, S. Ayesha, K. Nishtha, et al. Comparative evaluation of various total antioxidant capacity assays applied to phytochemical compounds of Indian culinary spices. International Food Research Journal, 2013, 20(4): 1711−1716.
S. Fourati, R. Cristescu, A. Loboda, et al. Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination. Nature Communications, 2016, 7: 10369. https://doi.org/10.1038/ncomms10369
S. Fujisaka, I. Usui, A. Bukhari, et al. Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes, 2009, 58(11): 2574−2582. https://doi.org/10.2337/db08-1475
M. Stone, D. Brambilla, K. Murcia, et al. Feasibility of routine ferritin testing for donor management: Validation of delayed processing and demonstration of within donor reproducibility over time. Transfusion, 2016, 56(10): 2422−2425. https://doi.org/10.1111/trf.13793
T. Kawasaki, T. Iwasaki, I. Ohya, et al. Effects of sampling and storage method on chicken blood glucose measurement. The Journal of Poultry Science, 2020, 57(3): 241−245. https://doi.org/10.2141/jpsa.0190106
G.H. Guo, J. Dong, X.H. Yuan, et al. Clinical evaluation of the levels of 12 cytokines in serum/plasma under various storage conditions using evidence biochip arrays. Molecular Medicine Reports, 2013, 7(3): 775−780. https://doi.org/10.3892/mmr.2013.1263
H. Wu, S.Y. Sun, K. Tu, et al. A splicing-independent function of SF2/ASF in microRNA processing. Molecular Cell, 2010, 38(1): 67−77. https://doi.org/10.1016/j.molcel.2010.02.021
J.-C. Zhang, S.-X. Li, K. Hashimoto. R(–)-ketamine shows greater potency and longer lasting antidepressant effects than S (+)-ketamine. Pharmacology Biochemistry and Behavior, 2014, 116: 137−141. https://doi.org/10.1016/j.pbb.2013.11.033
P. Mukhopadhyay, S. Maity, S. Mandal, et al. Preparation, characterization and in vivo evaluation of pH sensitive, safe quercetin-succinylated chitosan-alginate core-shell-corona nanoparticle for diabetes treatment. Carbohydrate Polymers, 2018, 182: 42−51. https://doi.org/10.1016/j.carbpol.2017.10.098
A.A. Date, M.S. Nagarsenker, S. Patere, et al. Lecithin-based novel cationic nanocarriers (leciplex) II: Improving therapeutic efficacy of quercetin on oral administration. Molecular Pharmaceutics, 2011, 8(3): 716−726. https://doi.org/10.1021/mp100305h
P. Sathishkumar, Z.F. Li, R. Govindan, et al. Zinc oxide-quercetin nanocomposite as a smart nano-drug delivery system: Molecular-level interaction studies. Applied Surface Science, 2021, 536: 147741. https://doi.org/10.1016/j.apsusc.2020.147741
L. Xiao, G. Luo, Y.H. Tang, et al. Quercetin and iron metabolism: What we know and what we need to know. Food and Chemical Toxicology, 2018, 114: 190−203. https://doi.org/10.1016/j.fct.2018.02.022
T. Muthurajan, P. Rammanohar, N.P. Rajemdran, et al. Evaluation of a quercetin–gadolinium complex as an efficient positive contrast enhancer for magnetic resonance imaging. RSC Advances, 2015, 5(106): 86967−86979. https://doi.org/10.1039/C5RA16405B
D.M. Lebensztejn, M. Flisiak-Jackiewicz, I. Białokoz-Kalinowska, et al. Hepatokines and non-alcoholic fatty liver disease. Acta Biochimica Polonica, 2016, 63(3): 459−467. https://doi.org/10.18388/abp.2016_1252
E.M.M. Abdelraheem, K. Kurpiewska, J. Kalinowska-Tłuścik, et al. Artificial macrocycles by ugi reaction and passerini ring closure. The Journal of Organic Chemistry, 2016, 81(19): 8789−8795. https://doi.org/10.1021/acs.joc.6b01430
S.S. Hasan, S.I. Ahmed, N.I. Bukhari, et al. Use of complementary and alternative medicine among patients with chronic diseases at outpatient clinics. Complementary Therapies in Clinical Practice, 2009, 15(3): 152−157. https://doi.org/10.1016/j.ctcp.2009.02.003
S. Balsam, G.D. Fernando, A. Tripathy. The impact of firm strategy on performance measures used in executive compensation. Journal of Business Research, 2011, 64(2): 187−193. https://doi.org/10.1016/j.jbusres.2010.01.006
P. Ghosh, B. Rathinasabapathi, L.Q. Ma. Phosphorus solubilization and plant growth enhancement by arsenic-resistant bacteria. Chemosphere, 2015, 134: 1−6. https://doi.org/10.1016/j.chemosphere.2015.03.048
X. Yang, R. Kwitt, M. Styner, et al. Quicksilver: Fast predictive image registration–A deep learning approach. NeuroImage, 2017, 158: 378−396. https://doi.org/10.1016/j.neuroimage.2017.07.008
H.M. Tauqeer, S. Ali, M. Rizwan, et al. Phytoremediation of heavy metals by Alternanthera bettzickiana: Growth and physiological response. Ecotoxicology and Environmental Safety, 2016, 126: 138−146. https://doi.org/10.1016/j.ecoenv.2015.12.031
F. Saeed, M. Ahmad, Samia, et al. Phosphorus-doped CoFe2O4 nanoparticles decorated nitrogen-doped graphene for efficient and stable electrocatalytic water splitting. International Journal of Hydrogen Energy, 2024, 59: 1196−1204. https://doi.org/10.1016/j.ijhydene.2024.01.035
Samia, F. Saeed, J. Li, et al. Emerging trends in metal-organic framework (MOFs) photocatalysts for hydrogen energy using water splitting: A state-of-the-art review. Journal of Industrial and Engineering Chemistry, 2024, 131: 54−135. https://doi.org/10.1016/j.jiec.2023.10.055
G.A. Ashraf, R.T. Rasool, M.M. Fadhali, et al. Novel magnetic Carbon@BaBiFe12O19 photocatalyst for efficient pollutants degradation under peroxymonosulfate activation. Materials Science in Semiconductor Processing, 2024, 176: 108291. https://doi.org/10.1016/j.mssp.2024.108291
A. Ibrar, S.A. Shehzadi, F. Saeed, et al. Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery. Bioorganic &Medicinal Chemistry, 2018, 26(13): 3731−3762. https://doi.org/10.1016/j.bmc.2018.05.042
R. Amin, B.S. Liu, S. Ullah, et al. Study of mass transfer resistant effect during syn gas and hydrogen production through CO2/CH4 dry reforming on La/Mg supported co-Ni/MSU-S zeolite. The Lighthouse Journal of Natural Sciences, 2022, 1(02): 19−34.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY) (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
京公网安备11010802044758号