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Research Article | Open Access | Online First

The Novel MoS2/MnO2–BSA Nanocomposite Significantly Enhances Antitumour Efficacy through Synergistic Photothermal Therapy/Hemodynamic Therapy

Lingle Zhang1,§, Xiaoqing Qian2,3,§, Yingying Yang1, Tingting Xiang4, Jinrong SiTu1, Hongzhang Yan1, Kai Yang1,5,6( )
College of Fisheries and Life Science of Shanghai Ocean University, Shanghai 201306, China
Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Centre for Intelligent Diagnosis and Treatment Instruments, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
National Engineering Research Center for Nanotechnology, Shanghai 200241, China
School of Clinical Laboratory Science, Guizhou Medical University, Guiyang 550004, China
Department of Imaging Medicine and Nuclear Medicine Tongji Hospital, Shanghai 200065, China
Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233 China

§These authors contributed equally to this work.

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Graphical Abstract

Abstract

Cellular photothermal and chemical kinetic therapy has recently been acknowledged as an effective cancer treatment method. Photothermal therapy (PTT) works by transforming light energy into heat through the photothermal effects triggered by near-infrared (NIR) laser exposure. The employment of nanomaterials as carriers for PTT agents or as PTT agents themselves offers improved therapeutic outcomes with fewer side effects through enhanced photothermal conversion efficiency, accumulation of the PTT agents in the tumor tissue. In this work, we synthesized new MoS2/MnO2 nanomaterials modified with bovine serum protein to enhance the effectiveness of the Fenton-like reaction between MoS2 and MnO2 to produce •OH through photothermolysis excitation using a near-infrared (NIR) 808 nm laser. In vitro measurements further confirmed the exceptional ability of MoS2/MnO2–modified bovine hemoglobin (BSA) to destroy cancer cells. We believe that photothermal therapy can offer new insights into cancer therapy and greatly enhance the efficacy of chemotherapeutic tumor treatments.

Keywords

nanomaterialsphotothermal therapychemical kineticssynergistic therapy

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Nano Biomedicine and Engineering
DOI: 10.26599/NBE.2024.9290105
Cite this article:
Zhang L, Qian X, Yang Y, et al. The Novel MoS2/MnO2–BSA Nanocomposite Significantly Enhances Antitumour Efficacy through Synergistic Photothermal Therapy/Hemodynamic Therapy. Nano Biomedicine and Engineering, 2024, https://doi.org/10.26599/NBE.2024.9290105

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Received: 16 May 2024
Revised: 03 June 2024
Accepted: 10 July 2024
Published: 22 November 2024
© The Author(s) 2024.

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