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Research Article | Open Access | Online First

Water-bearable nacre-inspired composite via matrix-induced rapid mineralization as potential compact bone repair material

Yu-Lu Yang1,§Zhong-Yuan Yang1,§Qing-Sheng Zeng2Zi-Han Yang3Chao Fang4Zhi Chen1Duo-Hong Zou2,3 ( )Li-Bo Mao1 ( )Shu-Hong Yu1,5 ( )
Department of Chemistry, Institute of Biomimetic Materials and Chemistry, Anhui Engineering Laboratory of Biomimetic Materials, New Cornerstone Science Laboratory, Division of Nanomaterials and Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China
Department of College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei 230032, China
Department of Oral Surgery, Shanghai Key Laboratory of Stomatology, School of Medicine, National Clinical Research Center of Stomatology, Ninth People’s Hospital, Shanghai Jiao Tong University, Shanghai 200011, China
Department of Orthopedics, The First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, China
Institute of Innovative Materials, Department of Materials Science and Engineering, Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China

§ Yu-Lu Yang and Zhong-Yuan Yang contributed equally to this work.

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Graphical Abstract

Fabrication of water-bearable nacre-inspired composites via matrix-induced rapid mineralization and their mechanical and biological performance were reported.

Abstract

The mechanical properties of mineral-based structural composite materials can be notably improved by bioinspired multiscale structure designs, which benefits their practical applications. Matrix-induced mineralization process has proved an efficient way to synthesize bioinspired mineral-based composites. However, although it is much faster than the growth of natural biominerals, this process still consumes considerable time to produce a composite with limited size. We herein report a combinational fabrication strategy that integrates rapid organic matrix layer-induced mineralization and layer lamination. While the strategy is featured for time saving compared with previous methods based on mineralization, the size of the final composite can be increased simply by using larger layers. Macroscopic and microscopic mechanical characterizations of the composite reveal its good mechanical performance. More importantly, by spraying a water-insoluble polymer coating on each mineralized layer, the composite exhibits enhanced tolerance to water that wet samples retain good mechanical properties. Besides, the composite inherits the biocompatibility of its raw materials. These advantages ensure the application of such composite as compact bone repair material.

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Nano Research
Cite this article:
Yang Y-L, Yang Z-Y, Zeng Q-S, et al. Water-bearable nacre-inspired composite via matrix-induced rapid mineralization as potential compact bone repair material. Nano Research, 2024, https://doi.org/10.26599/NR.2025.94907143
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Received: 11 October 2024
Revised: 08 November 2024
Accepted: 18 November 2024
Published: 26 December 2024
© The Author(s) 2025. Published by Tsinghua University Press.

This is an open access article under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0, https://creativecommons.org/licenses/by/4.0/).

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