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Research Article | Open Access

Platelet-derived extracellular vesicles for endometrial regeneration towards efficient live birth

Dongxiao Li1, Yanhong Yang1, Bo Tian3, Chenmeng Zhou2, Shuting Gu1, Wenju Chang3, Bingbing Wu2, Dantong Dong1, Fang Xu2, Ziyang Yu1, Ling Zhou1, Chao Wang2 ( ), Hong Zhang1 ( )
Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China
Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou 215123, China
Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China
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Graphical Abstract

This work reports a novel platelet-derived extracellular vesicles (PEVs), which exhibit substantial regenerative potential in addressing endometrial injuries, effectively promoting endometrial regeneration and achieving a high live birth success rate in a murine model of endometrial damage. These results lay a foundation for the clinical application of PEV-based therapies in endometrial regeneration.

Abstract

Uterine infertility is a major global issue causing substantial physical and psychological hardship for individuals struggling to conceive, while endometrium injury is one of the crucial factors causing infertility. Here, we demonstrate that platelet-derived extracellular vesicles (PEVs) have excellent regenerative ability in treating endometrial injuries, facilitating endometrium regeneration and resulting in a highly efficient live birth rate in the endometrium-injured murine model. We further investigated the underlying mechanisms by which PEVs affect the endometrium, showing their ability to promote neovascularization and suppress fibrosis. More importantly, the regenerative endometrium is more receptive to embrace the embryo, which can sustain the normal pregnancy. Our finding serves as a foundational basis for advancing the clinical translation of platelet-rich plasma (PRP) and PEVs therapies for endometrial regeneration.

Keywords

endometrium regenerationfertility restorationplatelet-derived extracellular vesiclesplatelet-rich plasma

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Nano Research
Volume 18 Issue 2,
February 2025
Article number: 94907176
DOI: 10.26599/NR.2025.94907176
Cite this article:
Li D, Yang Y, Tian B, et al. Platelet-derived extracellular vesicles for endometrial regeneration towards efficient live birth. Nano Research, 2025, 18(2): 94907176. https://doi.org/10.26599/NR.2025.94907176

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Received: 30 September 2024
Revised: 21 November 2024
Accepted: 05 December 2024
Published: 06 January 2025
© The Author(s) 2025. Published by Tsinghua University Press.

This is an open access article under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0, https://creativecommons.org/licenses/by/4.0/).
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