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Research Article | Open Access

Rational construction of enzyme-like stereoselective magnetic chiral nanozymes

Xuan Chen1,2,§, Shenli Wang3,§, Xiaoxiao Zhang4, Stefanos Mourdikoudis5, Chengxiao Song1, Leung Siu Lun4, Juan Xie1, Wing-leung Wong4, Jorge Perez-Juste5, Isabel Pastoriza-Santos5 (), Kwok-Yin Wong4 (), Guangchao Zheng1,2 ()
Colloidal Physics Group, Key Laboratory of Materials Physics, Ministry of Education, School of Physics and Laboratory of Zhongyuan Light, Zhengzhou University, Zhengzhou 450001, China
Institute of Quantum Materials and Physics, Henan Academy of Sciences, Zhengzhou 450046, China
College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China
State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong 999077, China
CINBIO, Universidade de Vigo, Department of Physical Chemistry, Campus Universitario Lagoas Marcosende, 36310 Vigo, Spain

§ Xuan Chen and Shenli Wang contributed equally to this work.

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Different morphologies of chiral cobalt superstructures (CoSSs) can be synthesized by adjusting the concentration of the precursor and the polarity of the solvent. The applications of the materials coming from their peroxidase activity were investigated. As the optical activity would change under the influence of magnetic fields, the peroxidase activity of the materials was also studied in the above condition.

Abstract

Recent studies support that magnetic chiral nanozymes, integrating the features of chirality, magnetism, and enzyme-like catalysis, provide new insights into the synthetic methodologies and applications of chiral nanozymes. In this study, we present the design of novel magnetic chiral cobalt superstructures (CoSSs) synthesized by the regulation of complex formation kinetics of Co3+ with chiral ligands (L- or D-tartaric acid) under varying metal-to-ligand molar ratios and solvent polarity. This approach yielded a series of CoSSs with varying symmetry from high to low. The chiral CoSSs exhibited chirality-dependent peroxidase (POD)-like activity, demonstrating a high affinity of L-CoSSs towards substrates, with a chiral selective factor of approximately 1.37. In addition, the magneto-optical effects of the chiral CoSSs significantly enhanced their chiroptical performance from ultraviolet–visible (UV–vis) to near-infrared region. Under a magnetic field, the affinity of chiral CoSSs for substrates increases, while the chiral selective factor was modified to 0.76. This research on magnetic chiral CoSSs nanozymes opens promising new avenues for the application of artificial enzymes in fields, such as antibacterial technology, drug delivery, and biocatalysis.

Keywords

chiral cobalt superstructureschirality originsolvent effectmagnetic circular dichroismenzyme-like stereoselectivity

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Nano Research
Volume 18 Issue 4,
April 2025
Article number: 94907307
DOI: 10.26599/NR.2025.94907307
Cite this article:
Chen X, Wang S, Zhang X, et al. Rational construction of enzyme-like stereoselective magnetic chiral nanozymes. Nano Research, 2025, 18(4): 94907307. https://doi.org/10.26599/NR.2025.94907307
Topics:
CatalystsCircular dichroism spectroscopyEnzyme kineticsMagnetite nanoparticles Microstructure
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