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Research Article | Open Access

Chronic restraint stress induces gastrointestinal function alternation: A potential role of the ArhGEF18-RhoA/Rho signaling pathway in the brain–gut axis under stress

The Institute of Neuroscience, Soochow University, Suzhou 215123, China
Departments of Neurology, the First Affiliated Hospital of Soochow University, Suzhou 215006 China
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Abstract

Depression is one of the common psychiatric diseases worldwide. Previous studies showed that chronic stress could increase defecation and inhibit weight gain; however, the effects of chronic stress on gastrointestinal peristalsis had not been clarified. To study the mechanisms of depression, chronic restraint stress (CRS) is widely used as a traditional depressive animal model. In this study, we investigate the effects of CRS on gastric emptying and intestinal propulsion in mice. Our results showed that the mice exhibited obvious depression-like behaviors 4 weeks after CRS. Compared with the control group, gastric emptying and intestinal propulsion were significantly decreased in the CRS group. Further, we examined the expression of ArhGEF18, a Rho-specific guanine nucleotide exchanging factor, which was significantly reduced in the gut in the CRS group. Therefore, CRS caused depressive behaviors and abnormal gastrointestinal function. The ArhGEF18-RhoA/Rho signaling pathway may be a potential mediator in the brain–gut axis under stress.

Keywords

chronic restraint stressdepressionbraingutArhGEF18

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Stress and Brain
Volume 2 Issue 1-2,
June 2022
Pages 31-38
DOI: 10.26599/SAB.2022.9060015
Cite this article:
Ma X, Li H, Wang W, et al. Chronic restraint stress induces gastrointestinal function alternation: A potential role of the ArhGEF18-RhoA/Rho signaling pathway in the brain–gut axis under stress. Stress and Brain, 2022, 2(1-2): 31-38. https://doi.org/10.26599/SAB.2022.9060015

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Received: 21 May 2022
Revised: 28 June 2022
Accepted: 06 July 2022
Published: 18 July 2022
© The Author(s) 2022

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attributtion-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission.
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