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Research Article | Open Access

Behavior-inhibition effects of hippocampal dentate gyrus overactivation after single ethanol vapor

Xin-Yue Wang1,2,§, Jie Li1,2,§, Wan-Kun Gong1,2( ), Wei-Jie Xie1,2( )
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China

§ Xin-Yue Wang and Jie Li contributed equally to this work.

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Abstract

Alcohol use disorder (AUD) is a common mental disorder that may cause dementia and mood disorders such as anxiety. The dentate gyrus (DG) is a key brain region for dementia as well as anxiety, while the underlying mechanisms of DG-based behavioral impairments induced by ethanol are not fully understood. Here we report the DG-based behavior inhibition using the ethanol vapor exposure procedure combined with behavioral tasks. The results indicate that single ethanol vapor exposure leads to working memory impairments and decreased anxiety-like behaviors 24 h after single ethanol vapor exposure. Notably, the c-Fos staining shows that the hippocampal DG is overactivated by ethanol administration, which implies DG plays a pivotal role in mediating the working memory and anxiety-like behaviors induced by ethanol vapor exposure. This links overactivation effects of ethanol vapor on hippocampal DG functions to ethanol-induced behavior inhibition, suggesting that future studies concerning ethanol-induced cognitive and mood disorders may focus more on the abnormal activity of this brain region.

Keywords

Alcohol use disorderdentate gyrusethanol vapor exposureworking memoryanxiety

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Stress and Brain
Volume 2 Issue 3,
September 2022
Pages 111-119
DOI: 10.26599/SAB.2022.9060018
Cite this article:
Wang X-Y, Li J, Gong W-K, et al. Behavior-inhibition effects of hippocampal dentate gyrus overactivation after single ethanol vapor. Stress and Brain, 2022, 2(3): 111-119. https://doi.org/10.26599/SAB.2022.9060018

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Received: 02 May 2022
Accepted: 17 October 2022
Published: 26 October 2022
© The Author(s) 2022

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attributtion-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission.
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