AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Stress and Brain Article
PDF (1.2 MB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Research Article | Open Access

βCaMKII overexpression in the dentate gyrus does not result in depression- and anxiety-like behaviors in mice

Key Laboratory of Brain Functional Genomics, Ministry of Education, School of Life Sciences, East China Normal University, Shanghai 200062, China
Shanghai Key Laboratory of Mental Health and Psychological Crisis, Affiliated Mental Health Center (ECNU), Positive Education China Academy, Juzhe Xi’s Master Workroom of Shanghai School Mental Health Service, School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China
Tong Ren Hospital Shangai Jiao Tong University School of Medicine, Shanghai 200336, China
School of Data Science and Engineering, East China Normal University, Shanghai 200062, China
Sagol Department of Neurobiology, University of Haifa, Haifa 3498838, Israel

§ Juzhe Xi and Pengcheng Yin contributed equally to this work.

Show Author Information

Abstract

Beta-Ca2+/calmodulin-dependent protein kinase II (βCaMKII) is known as a powerful regulator of lateral habenula neuron function and a key molecular determinant of depression. βCaMKII is also abundant in the hippocampus, especially in the dentate gyrus (DG). However, whether βCaMKII in the DG is also involved in emotional behaviors remains unknown. In this study, using βCaMKII-F90G transgenic mice, in which the overexpression of βCaMKII is restricted to the DG, we demonstrated that βCaMKII overexpression in the DG has no effect on the level of anxiety in mice in open field test or light–dark box test. Moreover, tail suspension test and forced swim test showed that the level of depression in βCaMKII-F90G transgenic mice and their littermates was comparable. Taken together, our findings indicate that βCaMKII overexpression in the DG does not result in depression- and anxiety-like behaviors in mice and provide evidence that the function of βCaMKII in emotional behaviors is brain region specific.

Keywords

beta-Ca2+/calmodulin-dependent protein kinase (βCaMKII)dentate gyrus (DG)depressionanxiety

References

[1]
Stone, S. S. D., Teixeira, C. M., Devito, L. M., Zaslavsky, K., Josselyn, S. A., Lozano, A. M., Frankland, P. W. Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 2011, 31(38): 13469–13484.
Crossref Google Scholar
[2]
Walker, A. K., Rivera, P. D., Wang, Q., Chuang, J. C., Tran, S., Osborne-Lawrence, S., Estill, S. J., Starwalt, R., Huntington, P., Morlock, L. et al. The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis. Molecular Psychiatry, 2015, 20(4): 500–508.
Crossref Google Scholar
[3]
Tunc-Ozcan, E., Peng, C. Y., Zhu, Y. W., Dunlop, S. R., Contractor, A., Kessler, J. A. Activating newborn neurons suppresses depression and anxiety-like behaviors. Nature Communications, 2019, 10: 3768.
Crossref Google Scholar
[4]
Yin, P. C., Xu, H., Wang, Q., Wang, J. Y., Yin, L., Xu, M. C., Xie, Z. Y., Liu, W. Z., Cao, X. H. Overexpression of βCaMKII impairs behavioral flexibility and NMDAR-dependent long-term depression in the dentate gyrus. Neuropharmacology, 2017, 116: 270–287.
Crossref Google Scholar
[5]
Wang, Z., Neylan, T. C., Mueller, S. G., Lenoci, M., Truran, D., Marmar, C. R., Weiner, M. W., Schuff, N. Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder. Archives of General Psychiatry, 2010, 67(3): 296.
Crossref Google Scholar
[6]
Villarreal, G. Reduced hippocampal volume and total white matter volume in posttraumatic stress disorder. Biological Psychiatry, 2002, 52(2): 119–125.
Crossref Google Scholar
[7]
Smith, M. E. Bilateral hippocampal volume reduction in adults with post-traumatic stress disorder: A meta-analysis of structural MRI studies. Hippocampus, 2005, 15(6): 798–807.
Crossref Google Scholar
[8]
Bremner, J. D., Vythilingam, M., Vermetten, E., Southwick, S. M., McGlashan, T., Nazeer, A., Khan, S., Vaccarino, L. V., Soufer, R., Garg, P. K. et al. MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder. The American Journal of Psychiatry, 2003, 160(5): 924–932.
Crossref Google Scholar
[9]
Gurvits, T. V. Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder. Biological Psychiatry, 1996, 40(11): 1091–1099.
Crossref Google Scholar
[10]
Liu, X., Ramirez, S., Pang, P. T., Puryear, C. B., Govindarajan, A., Deisseroth, K., Tonegawa, S. Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature, 2012, 484(7394): 381–385.
Crossref Google Scholar
[11]
Tonegawa, S., Morrissey, M. D., Kitamura, T. The role of engram cells in the systems consolidation of memory. Nature Reviews Neuroscience, 2018, 19(8): 485–498.
Crossref Google Scholar
[12]
Ramirez, S., Liu, X., MacDonald, C. J., Moffa, A., Zhou, J., Redondo, R. L., Tonegawa, S. Activating positive memory engrams suppresses depression-like behaviour. Nature, 2015, 522(7556): 335–339.
Crossref Google Scholar
[13]
Sahay, A., Hen, R. E. Adult hippocampal neurogenesis in depression. Nature Neuroscience, 2007, 10(9): 1110–1115.
Crossref Google Scholar
[14]
Kang, E., Wen, Z., Song, H., Christian, K. M., Ming, G. L. Adult neurogenesis and psychiatric disorders. Cold Spring Harbor Perspectives in Biology, 2016, 8(9): a019026.
Crossref Google Scholar
[15]
Christian, K. M., Song, H. J., Ming, G. L. Functions and dysfunctions of adult hippocampal neurogenesis. Annual Review of Neuroscience, 2014, 37: 243–262.
Crossref Google Scholar
[16]
Gonçalves, J. T., Schafer, S. T., Gage, F. H. Adult neurogenesis in the hippocampus: From stem cells to behavior. Cell, 2016, 167(4): 897–914.
Crossref Google Scholar
[17]
Anacker, C., Luna, V. M., Stevens, G. S., Millette, A., Shores, R., Jimenez, J. C., Chen, B., Hen, R. Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus. Nature, 2018, 559(7712): 98–102.
Crossref Google Scholar
[18]
Jin, J., Kim, S. N., Liu, X., Zhang, H., Zhang, C., Seo, J. S., Kim, Y., Sun, T. miR-17-92 cluster regulates adult hippocampal neurogenesis, anxiety, and depression. Cell Reports, 2016, 16(6): 1653–1663.
Crossref Google Scholar
[19]
Lisman, J., Schulman, H., Cline, H. The molecular basis of CaMKII function in synaptic and behavioural memory. Nature Reviews Neuroscience, 2002, 3(3): 175–190.
Crossref Google Scholar
[20]
Li, K., Zhou, T., Liao, L. J., Yang, Z. F., Hu, H. L. Beta CaMKII in lateral habenula mediates core symptoms of depression. Science, 2013, 341(6149): 1016–20.
Crossref Google Scholar
[21]
Cho, M. H., Cao, X., Wang, D., Tsien, J. Z. Dentate gyrus-specific manipulation of beta-Ca2+/calmodulin-dependent kinase II disrupts memory consolidation. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104(41): 16317–16322.
Crossref Google Scholar
[22]
Koch, S. B. J., Morey, R. A., Roelofs, K. The role of the dentate gyrus in stress-related disorders. Molecular Psychiatry, 2020, 25(7): 1361–1363.
Crossref Google Scholar
[23]
Nuninga, J. O., Mandl, R. C. W., Sommer, I. E. C. Correction: The dentate gyrus in depression: Directions for future research. Molecular Psychiatry, 2021, 26(6): 2677.
Crossref Google Scholar
[24]
Niewoehner, B., Single, F. N., Hvalby Ø, Jensen, V., Meyer zum Alten Borgloh, S., Seeburg, P. H., Rawlins, J. N., Sprengel, R., Bannerman, D. M. Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus. The European Journal of Neuroscience, 2007, 25(3): 837–846.
Crossref Google Scholar
[25]
Meng, F. T., Liu, J., Dai, J. J., Lian, H. F., Jiang, S. J., Li, Q. Y., Wu, M., Wang, W. T., Wang, D., Zhao, D. et al. PPM1F in dentate gyrus modulates anxiety-related behaviors by regulating BDNF expression via AKT/JNK/p-H3S10 pathway.Molecular Neurobiology, 2021, 58(7): 3529–3544.
Crossref Google Scholar
[26]
Lu, B., Zhang, T. Y., Yang, F. Bone in the brain? osteocalcin-expressing neurons in adult hippocampus promote neurogenesis and suppress anxiety. Biological Psychiatry, 2021, 89(6): 539–540.
Crossref Google Scholar
[27]
Yamasaki, N., Maekawa, M., Kobayashi, K., Kajii, Y., Maeda, J., Soma, M., Takao, K., Tanda, K., Ohira, K., Toyama, K. et al. Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders. Molecular Brain, 2008, 1(1): 6.
Crossref Google Scholar
[28]
Robison, A. J. Emerging role of CaMKII in neuropsychiatric disease. Trends in Neurosciences, 2014, 37(11): 653–662.
Crossref Google Scholar
[29]
Rawat, R., Tunc-Ozcan, E., McGuire, T. L., Peng, C. Y., Kessler, J. A. Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice. Nature Communications, 2022, 13: 2650.
Crossref Google Scholar
[30]
Abdoulaye, I. A., Wu, S. S., Chibaatar, E., Yu, D. F., Le, K., Cao, X. J., Guo, Y. J. Ketamine induces lasting antidepressant effects by modulating the NMDAR/ CaMKII-mediated synaptic plasticity of the hippocampal dentate gyrus in depressive stroke model. Neural Plasticity, 2021, 2021: 6635084.
Crossref Google Scholar
[31]
Dias, G. P., Cavegn, N., Nix, A., do Nascimento Bevilaqua, M. C., Stangl, D., Zainuddin, M. S., Nardi, A. E., Gardino, P. F., Thuret, S. The role of dietary polyphenols on adult hippocampal neurogenesis: Molecular mechanisms and behavioural effects on depression and anxiety. Oxidative Medicine and Cellular Longevity, 2012, 2012: 541971.
Crossref Google Scholar
[32]
David, D. J., Wang, J. W., Samuels, B. A., Rainer, Q., David, I., Gardier, A. M., Hen, R. Implications of the functional integration of adult-born hippocampal neurons in anxiety-depression disorders. The Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry, 2010, 16(5): 578–591.
Crossref Google Scholar
Stress and Brain
Volume 2 Issue 4,
December 2022
Pages 162-173
DOI: 10.26599/SAB.2022.9060025
Cite this article:
Xi J, Yin P, Kang Y, et al. βCaMKII overexpression in the dentate gyrus does not result in depression- and anxiety-like behaviors in mice. Stress and Brain, 2022, 2(4): 162-173. https://doi.org/10.26599/SAB.2022.9060025

4177

Views

245

Downloads

0

Crossref

Altmetrics
Received: 05 September 2022
Revised: 17 October 2022
Accepted: 21 November 2022
Published: 29 December 2022
© The Author(s) 2022

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attributtion-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission.
Return