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Review Article | Open Access

Molecular mechanisms of glial cells in brain disorders following physical exercise

School of Traditional Chinese Medicine, Jinan University, 510632 Guangzhou, China
Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, 510632 Guangzhou, China
State Key Laboratory of Brain and Cognitive Science, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 999077 Hong Kong, China
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Abstract

Physical exercise generally improves health in humans and animals and may enhance cognitive function and neural function in the brain, especially in the prefrontal cortex and hippocampus. It is also a promising intervention for brain disorders such as psychiatric conditions and neurodegenerative diseases. The neuroprotective mechanisms of exercise are related to synaptic plasticity, neurogenesis, and autophagy. Moreover, the therapeutic effects of exercise are associated with glial cell function in the brain. In this review, we examine the relationship between glial cell function and brain disorders. We also consider the role of glial cells in modulating the effects of exercise on the molecular mechanisms and neural circuits involved in central and peripheral brain function. This review demonstrates that glial cells may play an important role in the effects of physical exercise interventions on the brain, particularly in those with neurological disorders.

Keywords

Exerciseglial cellsneural network

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Stress and Brain
Volume 3 Issue 4,
December 2023
Pages 179-190
DOI: 10.26599/SAB.2023.9060004
Cite this article:
Liu Y, Ran S, So K-F, et al. Molecular mechanisms of glial cells in brain disorders following physical exercise. Stress and Brain, 2023, 3(4): 179-190. https://doi.org/10.26599/SAB.2023.9060004

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Received: 28 November 2023
Revised: 15 December 2023
Accepted: 15 December 2023
Published: 05 December 2023
© The Author(s) 2023

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