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Review Article | Open Access

Gut–vagus–NTS neural pathway in controlling feeding behaviors

School of Sport Science, Beijing Sport University, Beijing 100084, China
Department of Hematology, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China
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Abstract

Obesity has become a worldwide disease, posing a rapidly increasing challenge to the global healthcare system. The primary reason for obesity is that food intake exceeds the body’s needs. The central nervous system monitors the body’s energy status by continuously receiving peripheral gut-derived signals and functions as a master regulator in controlling feeding behaviors. Vagal afferents transmit gut-derived consumption signals from the periphery to the hindbrain (e.g., the nucleus of the solitary tract (NTS)). In contrast, vagal efferent nerves send commands to regulate peripheral organ activities. However, the precise role of the gut–vagus–NTS pathway and the gut–brain axis in regulating food intake is not yet fully understood. This review highlights the key roles of the NTS, vagal sensory neurons, and the gastrointestinal system in regulating feeding behaviors.

Keywords

nucleus of the solitary tract (NTS)vagus nervenodose gangliongut signalsfeeding behavior

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Stress and Brain
Volume 3 Issue 1,
March 2023
Pages 19-34
DOI: 10.26599/SAB.2023.9060033
Cite this article:
Chen J, Zhan C. Gut–vagus–NTS neural pathway in controlling feeding behaviors. Stress and Brain, 2023, 3(1): 19-34. https://doi.org/10.26599/SAB.2023.9060033

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Received: 15 July 2022
Revised: 21 October 2022
Accepted: 20 December 2022
Published: 09 June 2023
© The Author(s) 2023

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