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This study aimed to investigate the protective mechanism of Acaudina leucoprocta peptides (ALPs) in the kidney of type Ⅱ diabetes mice (db/db mice). Serum lipid and glucose indexes were detected in diabetes mice after ALPs treatment. The two-dimensional gel electrophoresis was used to study the kidney protein of diabetic mice. The differential protein screening, GO function annotation, and metabolic pathways were used to determine the protective mechanism of ALPs in the kidney of diabetic mice. The symptoms of db/db mice were alleviated after 10 weeks of treatment with ALPs. The content of TC, TG, and LDL-C in the ALPs group was significantly decreased and the level of HDL-C was increased. After ALPs treatment, the urine glucose and fasting blood glucose of diabetes mice were significantly reduced. The expression of Haptoglobin was up-regulated, it plays a role in anti-inflammatory and immune regulation. And the expression of alpha-2-HS-glycoproteins was down-regulated, then the insulin signal pathway was restored to normal condition, to improve the symptoms of diabetes. This study provided a new strategy that will help treat diabetes.
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