AI Chat Paper
Discover the SciOpen Platform and Achieve Your Research Goals with Ease.
Search articles, authors, keywords, DOl and etc.
{{expandStatus?'Exit ':''}}Advanced Search
The globus pallidus internus (GPi) was considered a common target for stimulation in Parkinson’s disease (PD). Located deep in the brain and of small size, pinpointing it during surgery is challenging. Multi-channel microelectrode arrays (MEAs) can provide micrometer-level precision functional localization, which can maximize the surgical outcome. In this paper, a 64-channel MEA modified by platinum nanoparticles with a detection site impedance of 61.1 kΩ was designed and prepared, and multiple channels could be synchronized to cover the target brain region and its neighboring regions so that the GPi could be identified quickly and accurately. The results of the implant trajectory indicate that, compared to the control side, there is a reduction in local field potential (LFP) power in multiple subregions of the upper central thalamus on the PD-induced side, while the remaining brain regions exhibit an increasing trend. When the MEA tip was positioned at 8,700 μm deep in the brain, the various characterizations of the spike signals, combined with the electrophysiological characteristics of the β-segmental oscillations in PD, enabled MEAs to localize the GPi at the single-cell level. More precise localization could be achieved by utilizing the distinct characteristics of the internal capsule (ic), the thalamic reticular nucleus (Rt), and the peduncular part of the lateral hypothalamus (PLH) brain regions, as well as the relative positions of these brain structures. The MEAs designed in this study provide a new detection method and tool for functional localization of PD targets and PD pathogenesis at the cellular level.
Peppe A, Pierantozzi M, Bassi A, Altibrandi MG, Brusa L, Stefani A, Stanzione P, Mazzone P. Stimulation of the subthalamic nucleus compared with the globus pallidus internus in patients with Parkinson disease. J Neurosurg. 2004;101(2):195–200.
Xiao G, Song Y, Zhang Y, Xing Y, Xu S, Wang M, Wang J, Chen D, Chen J, Cai X. Dopamine and striatal neuron firing respond to frequency-dependent DBS detected by microelectrode arrays in the rat model of Parkinson’s disease. Biosensors. 2020;10(10):136.
Ogura M, Nakao N, Nakai E, Nakai K, Itakura T. Chronic electrical stimulation of the globus pallidus for treatment of Parkinson’s disease. Int Congr Ser. 2002;1232:895–899.
Au KLK, Wong JK, Tsuboi T, Eisinger RS, Moore K, Lemos Melo Lobo Jofili Lopes J, Holland MT, Holanda VM, Peng-Chen Z, Patterson A, et al. Globus pallidus internus (GPi) deep brain stimulation for Parkinson’s disease: Expert review and commentary. Neurol Ther. 2021;10(1):7–30.
Benhamou L, Cohen D. Electrophysiological characterization of entopeduncular nucleus neurons in anesthetized and freely moving rats. Front Syst Neurosci. 2014;8:7.
Haas CA. Revisiting brain stimulation in Parkinson’s disease. Science. 2021;374(6564):153–154.
Papp EA, Leergaard TB, Calabrese E, Johnson GA, Bjaalie JG. Waxholm Space atlas of the Sprague Dawley rat brain. Neuroimage. 2014;97:374–386.
Valsky D, Marmor-Levin O, Deffains M, Eitan R, Blackwell KT, Bergman H, Israel Z. Stop! border ahead: Automatic detection of subthalamic exit during deep brain stimulation surgery. Mov Disord. 2017;32(1):70–79.
Koivu M, Huotarinen A, Scheperjans F, Laakso A, Kivisaari R, Pekkonen E. Motor outcome and electrode location in deep brain stimulation in Parkinson’s disease. Brain Behav. 2018;8(7): Article e01003.
Chrastina J, Novák Z, Baláž M, Říha I, Bočková M, Rektor I. The role of brain shift, patient age, and Parkinson’s disease duration in the difference between anatomical and electrophysiological targets for subthalamic stimulation. Br J Neurosurg. 2013;27(5):676–682.
Xu Z, Mo F, Yang G, Fan P, Wang Y, Lu B, Xie J, Dai Y, Song Y, He E, et al. Grid cell remapping under three-dimensional object and social landmarks detected by implantable microelectrode arrays for the medial entorhinal cortex. Microsyst Nanoeng. 2022;8(1):104.
Mo F, Kong F, Yang G, Xu Z, Liang W, Liu J, Zhang K, Liu Y, Lv S, Han M, et al. Integrated three-electrode dual-mode detection chip for place cell analysis: Dopamine facilitates the role of place cells in encoding spatial locations of novel environments and rewards. ACS Sens. 2023;8(12):4765–4773.
Mo F, Xu Z, Yang G, Fan P, Wang Y, Lu B, Liu J, Wang M, Jing L, Xu W, et al. Single-neuron detection of place cells remapping in short-term memory using motion microelectrode arrays. Biosens Bioelectron. 2022;217: Article 114726.
Jin X, Schwabe K, Krauss JK, Alam M. Coherence of neuronal firing of the entopeduncular nucleus with motor cortex oscillatory activity in the 6-OHDA rat model of Parkinson’s disease with levodopa-induced dyskinesias. Exp Brain Res. 2016;234(4):1105–1118.
Xu S, Zhang Y, Zhang S, Xiao G, Wang M, Song Y, Gao F, Li Z, Zhuang P, Chan P, et al. An integrated system for synchronous detection of neuron spikes and dopamine activities in the striatum of Parkinson monkey brain. J Neurosci Methods. 2018;304:83–91.
Kimura A, Yokoi I, Imbe H, Donishi T, Kaneoke Y. Distinctions in burst spiking between thalamic reticular nucleus cells projecting to the dorsal lateral geniculate and lateral posterior nuclei in the anesthetized rat. Neuroscience. 2012;226:208–226.
Joksovic PM, Todorovic SM. Isoflurane modulates neuronal excitability of the nucleus reticularis thalami in vitro. Ann N Y Acad Sci. 2010;1199(1):36–42.
McGregor MM, Nelson AB. Circuit mechanisms of Parkinson’s disease. Neuron. 2019;101(6):1042–1056.
Galvan A, Devergnas A, Wichmann T. Alterations in neuronal activity in basal ganglia-thalamocortical circuits in the parkinsonian state. Front Neuroanat. 2015;9:5.
Yang G, Wang Y, Mo F, Xu Z, Lu B, Fan P, Kong F, Xu W, He E, Zhang K, et al. PEDOT-citrate/SIKVAV modified bioaffinity microelectrode arrays for detecting theta rhythm cells in the retrosplenial cortex of rats under sensory conflict. Sens Actuators B Chem. 2024;399:Article 134802.
Boëx C, Awadhi AA, Tyrand R, Corniola MV, Kibleur A, Fleury V, Burkhard PR, Momjian S. Validation of lead-DBS β-oscillation localization with directional electrodes. Bioengineering. 2023;10(8):898.
Qian K, Wang J, Rao J, Zhang P, Sun Y, Hu W, Hao J, Jiang X, Fu P. Intraoperative microelectrode recording under general anesthesia guided subthalamic nucleus deep brain stimulation for Parkinson’s disease: One institution’s experience. Front Neurol. 2023;14:1117681.
Abe Y, Tsurugizawa T, Le Bihan D. Water diffusion closely reveals neural activity status in rat brain loci affected by anesthesia. PLoS Biol. 2017;15(4):Article e2001494.
Rao AT, Chou KL, Patil PG. Localization of deep brain stimulation trajectories via automatic mapping of microelectrode recordings to MRI. J Neural Eng. 2023;20(1):Article 016056.
Schulder M, Mishra A, Mammis A, Horn A, Boutet A, Blomstedt P, Chabardes S, Flouty O, Lozano AM, Neimat JS, et al. Advances in technical aspects of deep brain stimulation surgery. Stereotact Funct Neurosurg. 2023;101(2):112–134.
Li Y, Lopez-Huerta VG, Adiconis X, Levandowski K, Choi S, Simmons SK, Arias-Garcia MA, Guo B, Yao AY, Blosser TR, et al. Distinct subnetworks of the thalamic reticular nucleus. Nature. 2020;583(7818):819–824.
Nagy JI, Carter DA, Fibiger HC. Anterior striatal projections to the globus pallidus, entopeduncular nucleus and substantia nigra in the rat: The GABA connection. Brain Res. 1978;158(1):15–29.
Sil T, Hanafi I, Eldebakey H, Palmisano C, Volkmann J, Muthuraman M, Reich MM, Peach R. Wavelet-based bracketing, time–frequency beta burst detection: New insights in Parkinson’s disease. Neurotherapeutics. 2023;20(6):1767–1778.
Weinberger M, Mahant N, Hutchison WD, Lozano AM, Moro E, Hodaie M, Lang AE, Dostrovsky JO. Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson’s disease. J Neurophysiol. 2006;96(6):3248–3256.
Conti A, Gambadauro NM, Mantovani P, Picciano CP, Rosetti V, Magnani M, Lucerna S, Tuleasca C, Cortelli P, Giannini G. A brief history of stereotactic atlases: Their evolution and importance in stereotactic neurosurgery. Brain Sci. 2023;13(5):830.
Cui Z, Jiang C, Hu C, Tian Y, Ling Z, Wang J, Fan T, Hao H, Wang Z, Li L. Safety and precision of frontal trajectory of lateral habenula deep brain stimulation surgery in treatment-resistant depression. Front Neurol. 2023;14:1113545.
Bahadori-Jahromi F, Salehi S, Madadi Asl M, Valizadeh A. Efficient suppression of parkinsonian beta oscillations in a closed-loop model of deep brain stimulation with amplitude modulation. Front Hum Neurosci. 2023;16:1013155.
Distributed under a Creative Commons Attribution License 4.0 (CC BY 4.0).
京公网安备11010802044758号