AI Chat Paper
Discover the SciOpen Platform and Achieve Your Research Goals with Ease.
Search articles, authors, keywords, DOl and etc.
{{expandStatus?'Exit ':''}}Advanced Search
To investigate the effectiveness of SMI in evaluating hepatic IRI and detecting its therapy response.
Thirty rats were randomly divided into sham (n=12),IRI (n=12),and andrographolide pretreatment (n=6) groups.SMI,pathological,and biochemical examinations were conducted for the sham and IRI groups at 4(n=6) and 24 h (n=6) after reperfusion,respectively.Two ultrasonologists measured the vascular index (Ⅵ).The interobserver agreement was evaluated using the intraclass correlation coefficient (ICC).The rat liver parameters,including Suzuki's score,alanine aminotransferase (ALT),and aspartate aminotransferase (AST),were obtained at different time steps in each group.For the andrographolide pretreatment group,data were obtained at 24 h after reperfusion to further verify the advantage of Ⅵ.Parameters were analyzed for correlations and compared between each group at 4 and 24 h.
The ICC between two ultrasonologists who measured the Ⅵ was 0.912(95% CI:0.889-0.940).Suzuki's score and Ⅵ were negatively correlated (r=-0.504,P=0.012).Compared with the sham group,the IRI group showed a significant decrease in the Ⅵ at 4 and 24 h after reperfusion[(24.78 ± 3.23) versus (20.22 ± 2.55);(22.67 ± 1.36) versus (19.27 ± 2.23),P <0.05)].The Ⅵ in the andrographolide pretreatment group was higher than that in the IRI group[(21.90 ± 1.47) versus (19.27 ± 2.23),P <0.05].
The Ⅵ on SMI can be used as a noninvasive and sensitive index to evaluate hepatic IRI and detect its therapeutic response.
Hilmi I, Horton CN, Planinsic RM, Sakai T, Nicolau-Raducu R, Damian D, et al. The impact of postreperfusion syndrome on short-term patient and liver allograft outcome in patients undergoing orthotopic liver transplantation. Liver Transpl 2008;14: 504-508.
Jeong SM. Postreperfusion syndrome during liver transplantation. Korean J Anesthesiol 2015;68: 527-539.
Li CH, Chen YW, Chen YL, Yao LB, Ge XL, Pan K, et al. Preserving low perfusion during surgical liver blood inflow control prevents hepatic microcirculatory dysfunction and irreversible hepatocyte injury in rats. Sci Rep 2015;5: 14406.
Xie F, Fei X, Zhang MB, Zhang Y, Wang HW, Tang J, et al. Quantitative evaluation of hepatic microvascular perfusion after ischemia-reperfusion injury in rabbits by contrast-enhanced ultrasound perfusion imaging. Ultrasound Med Biol 2018;44: 1053-1062.
Kondo T, Todoroki T, Hirano T, Schildberg FW, Messmer K. Impact of ischemia-reperfusion injury on dimensional changes of hepatic microvessels. Res Exp Med (Berl) 1998;198: 63-72.
Brito NB, de Souza Junior JM, Leão LR, Brito MV, Rêgo AC, Medeiros AC. Effects of andiroba (Carapa guianensis) oil on hepatic function of rats subjected to liver normothermic ischemia and reperfusion. Rev Col Bras Cir 2013;40: 476-479.
CW Guo, Y Zhang, XY LI, XM Cao, JH Zheng, CH Liang. Correlation between CT perfusion parameters and degrees of hepatic injury in acute hepatic ischemia reperfusion injury rabbit models. Chin J Med Imaging Technol 2011;7: 661-665.
Piscaglia F, Bolondi L; Italian Society for Ultrasound in Medicine and Biology (SIUMB) Study Group on Ultrasound Contrast Agents. The safety of Sonovue in abdominal applications: retrospective analysis of 23188 investigations. Ultrasound Med Biol 2006;32: 1369-1375.
Kusnetzky LL, Khalid A, Khumri TM, Moe TG, Jones PG, Main ML. Acute mortality in hospitalized patients undergoing echocardiography with and without an ultrasound contrast agent: results in 18, 671 consecutive studies. J Am Coll Cardiol 2008;51: 1704-1706.
Demené C, Deffieux T, Pernot M, Osmanski BF, Biran V, Gennisson JL, et al. Spatiotemporal clutter filtering of ultrafast ultrasound data highly increases Doppler and dltrasound sensitivity. IEEE Trans Med Imaging 2015;34: 2271-2285.
Kuroda H, Abe T, Kakisaka K, Fujiwara Y, Yoshida Y, Miyasaka A, et al. Visualizing the hepatic vascular architecture using superb microvascular imaging in patients with hepatitis C virus: A novel technique. World J Gastroenterol 2016;22: 6057-6064.
Balık AÖ, Kılıçoğlu ZG, Görmez A, Özkara S. Radiology-pathology correlation in staging of liver fibrosis using superb microvascular imaging. Diagn Interv Radiol 2019;25: 331-337.
Lee DH, Lee JY, Han JK. Superb microvascular imaging technology for ultrasound examinations: Initial experiences for hepatic tumors. Eur J Radiol 2016;85: 2090-2095.
Chae EY, Yoon GY, Cha JH, Shin HJ, Choi WJ, Kim HH. Added value of the vascular index on superb microvascular imaging for the evaluation of breast masses: comparison with grayscale ultrasound. J Ultrasound Med 2021;40: 715-723.
Lee EJ, Chang YW, Oh E, Hwang J, Kim HJ, Hong SS. Reproducibility and diagnostic performance of the vascular index of superb microvascular imaging in real-time breast ultrasonography for evaluating breast masses. Ultrasonography 2021;40: 398-406.
Suzuki S, Toledo-Pereyra LH, et al. Neutrophil infiltration as an important factor in liver ischemia and reperfusion injury. Modulating effects of FK506 and cyclosporine. Transplantation 1993;55: 1265-1272.
Ma Y, Wang GD, Wu LW, Hu RD. Dynamical changing patterns of histological structure and ultrastructure of liver graft undergoing warm ischemia injury from non-heart-beating donor in rats. World J Gastroenterol 2006;12:4902-4905.
Olthof PB, van Golen RF, Meijer B, et al. Warm ischemia time-dependent variation in liver damage, inflammation, and function in hepatic ischemia/reperfusion injury. Biochim Biophys Acta Mol Basis Dis 2017;1863:375-385.
Dar WA, Sullivan E, Bynon JS, Eltzschig H, Ju C. Ischaemia reperfusion injury in liver transplantation: Cellular and molecular mechanisms. Liver Int 2019;39:788-801.
Tazaki T, Sasaki T, Uto K, Yamasaki N, Tashiro S, Sakai R, et al. p130Cas, Crk-associated substrate plays essential roles in liver development by regulating sinusoidal endothelial cell fenestration. Hepatology 2010;52:1089-1099.
Teoh NC, Farrell GC. Hepatic ischemia reperfusion injury: pathogenic mechanisms and basis for hepatoprotection. J Gastroenterol Hepatol 2003;18:891-902.
Chen HW, Huang CS, Li CC, Lin AH, Huang YJ, Wang TS, et al. Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats. Toxicol Appl Pharmacol 2014;280:1-9.
Tang Y, Kong W, Zhao J, Chen Y, Liu L, Zhang G. Can Viscoelasticity measurements obtained through shear-Wave US elastography be used to monitor hepatic ischemia-reperfusion injury and treatment response? An animal study. Ultrasound Med Biol 2020;46:2464-2471.
Wang YJ, Wang JT, Fan QX, Geng JG. Andrographolide inhibits NF-kappaBeta activation and attenuates neointimal hyperplasia in arterial restenosis. Cell Res 2007;17:933-941.
Bao Z, Guan S, Cheng C, Wu S, Wong SH, Kemeny DM, et al. A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-kappaB pathway. Am J Respir Crit Care Med 2009;179:657-665.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
京公网安备11010802044758号