China’s total grain output has exceeded 650 million tons since seven years ago, with the great achievement of ever-increased grain output for 18 consecutive years. However, China’s cereal production is facing many severe challenges, such as the shortage of agricultural resources per capita, higher cost for crop production per hectare, sharp decrease of labor population and progressively increase of grain import. Therefore, it is necessary to discuss the frontiers and the directions of scientific and technological innovation in China’s field crop cultivation. According to the existing problems in field crop production, the major scientific and technological requirements of China’s field crop were elaborated, such as the cooperative cultivation of high-quality and high-yield and high-efficient, the green cultivation of carbon fixation and energy conservation and emission reduction, and the “unmanned” intelligent cultivation. The scientific and technological frontiers and development status and trends of field crop cultivation at home and abroad were analyzed emphatically. The key scientific and technological breakthrough directions and paths were pointed out in three aspects: The coordination cultivation of high-quality and high-yield and high-efficient, the green cultivation of carbon fixation and energy saving and emission reduction, and the “unmanned” intelligent cultivation. Finally, the measures and suggestions for scientific and technological innovation of China’s field crop cultivation were put forward from the aspects of policy top-level design and effective investment, increasing the research and development of basic theories, the key technologies and practical products, and increasing the cultivation of compound talents. In the future, it is necessary to significantly improve grain quality and planting efficiency under the premise of continuously increasing grain yield through the collaborative cultivation of high-quality, high-yield and high efficiency in field crop cultivation. Through the green cultivation of carbon fixation and energy conservation and emission reduction, less material input and high efficient utilization of resources can be achieved. Through integration and innovation of various aspects of agronomy and agricultural machinery intelligence, the “unmanned” intelligent cultivation can be constructed for greatly less labor input and higher efficiency of large-scale production. Finally, it is to realize Chinese style modernization of field crop production, to ensure grain security and effective supply of agricultural products.