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Research Article | Open Access

Spectrophotometric Determination of Etilefrine HCl, Salbutamol Sulphate and Tiemonium Methyl Sulphate Using Surface Plasmon Resonance Band of Gold Nanoparticles

Magda Mohamed Ayad, Hisham Ezzat Abdellatef, Mervat Mohamed Hosny, Naglaa Abdel-Sattar Kabil( )
Department of Analytical Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
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Abstract

A simple and sensitive method was developed for spectrophotometric determination of etilefrine hydrochloride, salbutamol sulphate and tiemonium methyl sulphate in pure form and in their pharmaceutical formulations. The method was based on reduction of gold solution to gold nanoparticles by the studied drugs in presence of sodium dodecyl sulphate as stabilising agent. Gold nanoparticles (Au NPs) showed a new absorption band at 530 nm that was used for quantitative determination of the cited drugs. Different variables were examined and optimised in the experiment as gold solution concentration, type of buffer, suitable pH, stabilising agent, order of addition, time and temperature of the reaction. Under optimum conditions, the calibration curves were linear with concentration ranges of 3.0-20.0, 5.0-18.0 and 2.0-26.0 μg/mL for etilefrine Hydrochloride, salbutamol sulphate and tiemonium methyl sulphate respectively. The method was applied successfully to determine the studied drugs in pure form and in their pharmaceutical dosage forms, exhibiting good reproducibility and accuracy.

Keywords

Gold nanoparticlesEtilefrine HydrochlorideSalbutamol sulphateTiemonium methyl sulphate

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Nano Biomedicine and Engineering
Volume 10 Issue 1,
March 2018
Pages 16-24
DOI: 10.5101/nbe.v10i1.p16-24
Cite this article:
Ayad MM, Abdellatef HE, Hosny MM, et al. Spectrophotometric Determination of Etilefrine HCl, Salbutamol Sulphate and Tiemonium Methyl Sulphate Using Surface Plasmon Resonance Band of Gold Nanoparticles. Nano Biomedicine and Engineering, 2018, 10(1): 16-24. https://doi.org/10.5101/nbe.v10i1.p16-24

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Received: 07 December 2017
Accepted: 25 January 2018
Published: 16 February 2018
© Magda Mohamed Ayad, Hisham Ezzat Abdellatef, Mervat Mohamed Hosny, and Naglaa Abdel-Sattar Kabil.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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